Correlation of cytogenetic results with immunophenotype, genotype, clinical features, and ras mutation in acute myeloid leukemia A study of 235 Chinese patients in Taiwan

Tien, Hwei‐Fang; Wang, Chiu Hwa; Lin, Ming Tseh; Lee, Fen Yu; Liu, Ming Chi; Chuang, Sou‐Ming; Chen, Yao Chang; Shen, Ming; Lin, Kai Hsin; Lin, Dong

doi:10.1016/0165-4608(95)00084-4

Cited by 102 publications

(89 citation statements)

References 37 publications

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“…The t(15;17) was seen in 14.5% of our AML patients, comparable with that observed in Taiwan (15%), Singapore (11%) and Japan (11%). 14,19,24 The frequency of t(15;17) in M3 in our series was only 56.0%, much lower than that reported in Japan (75.4%), Singapore (82.5%) and some western countries (around 90%). A possible explanation would be the methodology employed as most of the other countries, except France, use G-banding for cytogenetic analysis, whereas we use R-banding because of historical reasons.…”

Section: Cytogenetics Of Acute Myeloid Leukemia In China Y Cheng Et Alcontrasting

confidence: 43%

“…Reports in Japan and Taiwan showed a higher incidence of t(8;21) in their AML M2 patients (33.1 and 34%). 14,24 This was observed in only 22.1% of our subjects, closer to that observed in Singapore (14.5%) 22 and an American report (19.6%). 18 However, only 8.8% were reported in a German study, 6 suggesting that some geographic differences exist.…”

Section: Cytogenetics Of Acute Myeloid Leukemia In China Y Cheng Et Almentioning

confidence: 48%

“…6,[17][18][19][20][21][22][23][24][25][26] The results of this study compared with several population-based and regional studies are detailed in Table 3. These represent most large-scale published studies that deal exclusively with de novo AML.…”

Section: Cytogenetics Of Acute Myeloid Leukemia In China Y Cheng Et Almentioning

confidence: 99%

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Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

Cheng

Wang

et al. 2009

Leukemia

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Geographic heterogeneity of cytogenetic patterns in hematological malignancies has been reported earlier, but few systematic studies of cytogenetic abnormalities in acute myeloid leukemia (AML) patients are available. We examined the karyotypic patterns in 1432 de novo AML patients from a single center in China and compared our data with reports from other regions of the world. Chromosomal abnormalities were detected in 746 (58%) cases. The most frequent cytogenetic abnormality was t(15;17), detected in 14% of successful cases, followed by t(8;21) in 8%, and t(9;22), þ 21 and þ 8 each in 2%. The mean age of patients with a translocation karyotype was significantly younger than that of patients with normal, deletion or trisomy karyotypes. A higher incidence of AML M3 and a lower frequency of M4 were observed in the Asian population and the frequencies of certain cytogenetic aberrations were different from those in the earlier reports. Population-based age-specific incidences of AML were calculated and compared with those in western reports.

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Section: Cytogenetics Of Acute Myeloid Leukemia In China Y Cheng Et Alcontrasting

confidence: 43%

Section: Cytogenetics Of Acute Myeloid Leukemia In China Y Cheng Et Almentioning

confidence: 48%

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Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

Cheng

Wang

et al. 2009

Leukemia

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“…Metaphase chromosomes were banded by the G-banding method as described previously. 32 Immunophenotyping A panel of monoclonal antibodies, including myeloid-associated antigens (CD13, CD33, CD11b, CD14, CD15 and CD41a), as well as lymphoid-associated antigens (CD2, CD5, CD7, CD19, CD10 and CD20), and lineage-nonspecific antigens (HLA-DR, CD34 and CD56), was used to determine the immunophenotypes of leukemia cells as previously described. 33 …”

Section: Cytogenetic Analysismentioning

confidence: 99%

The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia

et al. 2010

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Although the clinical features of the Isocitrate dehydrogenase 2 (IDH2) mutation in acute myeloid leukemia (AML) have been characterized, its prognostic significance remains controversial and its stability has not been investigated. We analyzed 446 adults with primary non-M3 AML and found IDH2 R172, R140 and IDH1 R132 mutations occurred at a frequency of 2.9, 9.2 and 6.1%, respectively. Compared with wild-type IDH2, mutation of IDH2 was associated with higher platelet counts, intermediate-risk or normal karyotype and isolated þ 8, but was inversely correlated with expression of HLA-DR, CD34, CD15, CD7 and CD56, and was mutually exclusive with WT1 mutation and chromosomal translocations involving core-binding factors. All these correlations became stronger when IDH1 and IDH2 mutations were considered together. Multivariate analysis revealed IDH2 mutation as an independent favorable prognostic factor. IDH2 À /FLT3-ITD þ genotype conferred especially negative impact on survival. Compared with IDH2 R140 mutation, IDH2 R172 mutation was associated with younger age, lower white blood cell count and lactate dehydrogenase level, and was mutually exclusive with NPM1 mutation. Serial analyses of IDH2 mutations at both diagnosis and relapse in 121 patients confirmed high stability of IDH2 mutations. In conclusion, IDH2 mutation is a stable marker during disease evolution and confers favorable prognosis.

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“…23 Briefly, bone marrow (BM) cells were harvested either directly or after 1-3 days of unstimulated culture. Metaphase chromosomes were banded by the conventional trypsin-Giemsa banding technique and karyotyped according to ISCN.…”

Section: Patientsmentioning

confidence: 99%

Characterization of acute myeloid leukemia with MLL rearrangements – no increase in the incidence of coexpression of lymphoid-associated antigens on leukemic blasts

et al. 2000

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Correlation of cytogenetic results with immunophenotype, genotype, clinical features, and ras mutation in acute myeloid leukemia A study of 235 Chinese patients in Taiwan

Cited by 102 publications

References 37 publications

Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia

Characterization of acute myeloid leukemia with MLL rearrangements – no increase in the incidence of coexpression of lymphoid-associated antigens on leukemic blasts

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