Correlation of CT Perfusion Images with VEGF Expression in Solitary Brain Metastases

Zhang, Jianhua; Wang, Mingsheng; Pan, Haihong; Li, Shufeng; Wang, Zhong Qiu; Chen, Wangsheng

doi:10.7314/apjcp.2012.13.4.1575

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…A considerable proportion of adult cancer patients may develop cerebral metastases during the course of their disease (Chindaprasirt et al, 2012;Demircioglu et al, 2013;Mutlu et al, 2013;Sun et al, 2014). Different treatment modalities including conventional radiotherapy, radiosurgery, neurosurgical resection, and systemic therapy are used (Liu et al, 2012;Zeng et al, 2012;Zhang et al, 2012;Erten et al, 2013;Inamoto et al, 2014). Many patients with metastases to the brain receive radiosurgery alone.…”

Section: Discussionmentioning

confidence: 99%

A New Tool to Predict Survival after Radiosurgery Alone for Newly Diagnosed Cerebral Metastases

Rades

Huttenlocher

Dziggel

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Many patients with few cerebral metastases receive radiosurgery alone. The goal of this study was to create a tool to estimate the survival of such patients. To identify characteristics associated with survival, nine variables including radiosurgery dose, age, gender, Eastern cooperative oncology group performance score (ECOG-PS), primary tumor type, number/size of cerebral metastases, location of cerebral metastases, extra-cerebral metastases and time between cancer diagnosis and radiosurgery were analyzed in 214 patients. On multivariate analysis, age (p=0.03), ECOG-PS (p=0.02) and extra-cerebral metastases (p<0.01) had significant impacts on survival. Scoring points for each patient were obtained from 12-month survival rates (in %) related to the significant variables divided by 10. Addition of the scoring points of the three variables resulted in a patient's total predictive score. Two groups were designed, A (10-14 points) and B (16-17 points). Twelve-month survival rates were 33% and 77%, respectively (p<0.001). Median survival times were 8 and 20 months, respectively. Because most patients of group A died from extra-cerebral disease and/or new cerebral lesions, early systemic treatment and additional WBI should be considered. As cause of death in group B was mostly new cerebral metastases, additional WBI appears even more important for this group.

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Section: Discussionmentioning

confidence: 99%

A New Tool to Predict Survival after Radiosurgery Alone for Newly Diagnosed Cerebral Metastases

Rades

Huttenlocher

Dziggel

et al. 2015

Asian Pacific Journal of Cancer Prevention

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show abstract

The preliminary radiogenomics association between MR perfusion imaging parameters and genomic biomarkers, and their predictive performance of overall survival in patients with glioblastoma

et al. 2017

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The radiogenomics association of neovascularization is important for overall survival (OS) in glioblastoma patients and remains unclear. The purpose of this study is to assess the association between MR perfusion imaging derived parameters and genomic biomarkers of glioblastoma, and to evaluate their prognostic value. This retrospective study enrolled 41 patients with newly diagnosed glioblastoma. The mean and maximal relative cerebral blood volume (rCBV) ratio (rCBV and rCBV), derived from MR perfusion weighted imaging, of the enhancing tumor, as well as maximal rCBV ratio of peri-enhancing tumor area (rCBV) were measured. The ki-67 labeling index, mammalian target of rapamycin (mTOR) activation, epidermal growth factor receptor (EGFR) amplification, isocitrate dehydrogenase (IDH) mutation and TP53 were assessed. There was a significant correlation between rCBV and mTOR based on Pearson's correlations with Benjamini-Hochberg adjustment for controlling false discovery rate, p = 0.047. The rCBV showed significant correlation with mTOR (p = 0.0183) after adjustment of gender and EGFR status. The mean rCBV value of the patients with OS shorter than 14 months was significantly higher than patients with OS longer than 14 months, p = 0.002. The rCBV and age were the two strongest predictors of OS (hazard ratio = 1.29 and 1.063 respectively) by Cox regression analysis. This study showed that hemodynamic abnormalities of glioblastoma were associated with genomics activation status of mTOR-EGFR pathway, however, the radiogenomics associations are different in enhancing and peri-enhancing area of glioblastoma. The rCBV has better prognostic value than genomic biomarkers alone.

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Application of combination chemotherapy in two dimensional tumor growth model with heterogeneous vasculature

Lampropoulos

Kavousanakis

2023

Chemical Engineering Science

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Correlation of CT Perfusion Images with VEGF Expression in Solitary Brain Metastases

Cited by 3 publications

References 18 publications

A New Tool to Predict Survival after Radiosurgery Alone for Newly Diagnosed Cerebral Metastases

A New Tool to Predict Survival after Radiosurgery Alone for Newly Diagnosed Cerebral Metastases

The preliminary radiogenomics association between MR perfusion imaging parameters and genomic biomarkers, and their predictive performance of overall survival in patients with glioblastoma

Application of combination chemotherapy in two dimensional tumor growth model with heterogeneous vasculature

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