Correlation of coronary artery stenosis evaluation with left heart structure and function by multi-slice computed tomography

Abstract

ABSTRACT. The aim of this study was to determine the impact of multi-slice computed tomography (MSCT) evaluation of coronary artery stenosis on left heart structure and systolic function. Coronary artery CT angiography was performed in 200 patients diagnosed with coronary heart disease, and then according to the AHA coronary artery 17-segment fractionation method, the Gensini score (GS) was determined for every narrow segment, and one-stop assessment of the correlation between left heart structure and function was performed. After the grouping of GS quartiles from low to high, there were differences between different patients with regard to LVDD, LADD, LVEDV, LVESV, MM, LVEF, and FS, while no difference in SV and CO. GS showed linear negative correlation with LVEF and FS, and linear positive correlation with LVDD, LADD, LVEDV, LVESV, and MM, while no correlation with SV and CO. That is, GS of coronary artery stenosis was negatively correlated with left ventricular systolic function and positively correlated with myocardial mass. The narrower the coronary artery, the worse the cardiac function and the higher the myocardial hypertrophy. Coronary artery stenosis was one of the 5941 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (3): 5940-5948 (2014) Correlation of left heart structure and function important causes of the decrease in left ventricular systolic function and cardiac remodeling.

Endothelin-1 and ET receptors impair left ventricular function by mediated coronary arteries dysfunction in chronic intermittent hypoxia rats

“…Meanwhile, the augmented expression of ET A receptor largely contributed to coronary dysfunction by causing a potent vasoconstrictor response in the coronary arteries of hearts from CIH rats. Furthermore, the damage of coronary artery endothelial cell, the decreased endothelial ET B receptor expression and the reduction in NO release play an important role in enhancing coronary vasoconstriction that caused myocardial ischemia and hypoxia after CIH exposure, further leading to the failure of myocardial contractile function, cardiac enlargement and lower compliance (Song et al ).…”