Correlation of cord blood bilirubin values with neonatal jaundice in healthy newborns: A prospective observational study

Bhat, Jehangir Allam; Sheikh, Sheema; Ara, Roshan

doi:10.4103/amhs.amhs_2_19

Cited by 3 publications

(4 citation statements)

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“…14 In 2019, Jehangir, et al revealed in their study that cord blood bilirubin level <2.5 mg/dl has 8.82% sensitivity and 83.92% specificity of not developing hyperbilirubinemia while cord bilirubin levels ˃3mg/dl has 97% sensitivity and 99% specificity to develop raised bilirubin levels. 15 In another study done in 2019 by Muhammad Rafi cord blood bilirubin level of ≥2mg/dl had sensitivity of 90.48%, specificity 84.88% in prediction of neonatal hyperbilirubinemia encouraging it to be used as an early predicting tool. 16 In 2019 Vincenzo et al reported that newborns diagnosed with hyperbilirubinemia had higher cord blood bilirubin.…”

Section: Discussionmentioning

confidence: 99%

Umbilical Cord Blood Bilirubin and Determination of Neonatal Hyperbilirubinemia

Tahir¹,

Abid

Batool

et al. 2023

Ann Pak Inst Med Sci

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Objective: To determine accuracy of cord blood bilirubin in identifying significant neonatal hyperbilirubinemia. Methodology: A Cross sectional study was conducted in Pediatric department of Fauji Foundation Hospital Rawalpindi from Jan.2019 to June 2019. Cord blood samples were sent for the blood group and bilirubin levels. Neonates with cord bilirubin level > 2mg/dl and < 5 mg/dl were enrolled and admitted for 3 days and serum bilirubin level were done on 3rd day. Those developing significant hyperbilirubinemia were further investigated for hemoglobin, reticulocyte count, Coomb’s test and other causes. Results: Total 74 newborns at >35 weeks of gestation were included in the study of which 35 (47.3%) were male and 39 (52.7%) were female (male: female: 1:1.1). The data was analyzed using SPSS 17. At 3rd day of life mean ± SD cord blood bilirubin was 8.4 ± 2.7 mg/dl, mean direct bilirubin was 1.6 ± 0.9 mg/dl and mean indirect bilirubin was 6.8 ± 2.3mg/dl. Significant hyperbilirubinemia developed in 16 (21.6%) newborns at >35 weeks of gestation, who had a cord blood bilirubin level of > 2 mg/dl, so that the accuracy of cord blood bilirubin level (true positives) in determining significant hyperbilirubinemia was 21.6%. Conclusion: Cord blood bilirubin level >2mg/dl in all healthy term newborns predicts significant hyperbilirubinemia.

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Section: Discussionmentioning

confidence: 99%

Umbilical Cord Blood Bilirubin and Determination of Neonatal Hyperbilirubinemia

Tahir¹,

Abid

Batool

et al. 2023

Ann Pak Inst Med Sci

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“…Pada penelitian ini, berdasarkan kurva ROC didapatkan nilai batas kadar bilirubin umbilikal adalah 3,78 mg/dL dengan sensitivitas 90,0% dan spesifisitas 80%. Hasil penelitian ini sesuai dengan hasil penelitian oleh Bhat dkk 15 di India, kadar bilirubin umbilikal >3,5 mg/dl dapat memprediksi perkembangan ikterus patologis di kemudian hari dengan sensitivitas (97,06%), spesifisitas (99,22%), nilai prediksi positif (94,29%), dan nilai prediksi negatif (99,61%) yang tinggi. Penelitian oleh Baskar dkk 12 menemukan kadar bilirubin umbilikal dapat menjadi prediktor untuk hiperbilirubinemia dengan nilai batas kadar bilirubin umbilikal >3,25 mg/dl, sensitivitas 96% dan spesifisitas 96%.…”

Section: Pembahasanunclassified

“…16 Pendapat dari berbagai penelitian sebelumnya adalah bahwa kadar bilirubin serum yang tinggi saat lahir diprediksi akan mencapai puncak yang tinggi di kemudian hari. 3 Nilai bilirubin tali pusat untuk memprediksi hiperbilirubinemia yang bermakna masih diperdebatkan secara luas. Terdapat perbedaan antara hasil-hasil studi yang sudah dilakukan.…”

Section: Pembahasanunclassified

“…Oleh sebab itu, American Academy of Pediatrics (AAP) merekomendasikan untuk semua neonatus dinilai untuk adanya risiko hiperbilirubinemia sebelum pulang. [1][2][3] Pemeriksaan bilirubin darah umbilikal (UCB) setelah persalinan praktis, murah dan non-invasif. Beberapa penelitian sebelumnya telah menyelidiki kegunaan potensial pemeriksaan UCB dalam memprediksi hiperbilirubinemia di kemudian hari.…”

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Peran Kadar Bilirubin Umbilikal sebagai Prediktor Hiperbilirubinemia pada Neonatus

Harti¹,

Hafidh²,

Rokhayati³

2022

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Latar belakang. Kadar puncak bilirubin terjadi pada 72 hingga 96 jam setelah bayi baru lahir. Hiperbilirubinemia pada neonatus dapat berdampak serius jika tidak ditangani dengan tepat. Untuk menghindari dampak serius dari hiperbilirubinemia, dibutuhkan pemeriksaan yang dapat memprediksi hiperbilirubinemia pada neonatus.Tujuan. Mengetahui nilai prediksi kadar bilirubin umbilikal terhadap kejadian hiperbilirubinemia pada neonatus. Metode. Penelitian observasional analitik dengan pendekatan kohort prospektif. Pengambilan sampel dilakukan secara consecutive sampling pada bayi baru lahir di RSUD Dr. Moewardi pada bulan Januari 2021 – Juni 2021. Data dianalisis menggunakan uji chi square dan uji Mann Whitney, tingkat kemaknaan hasil uji ditentukan berdasarkan nilai p<0,05.Hasil. Dari 30 subyek neonatus, didapatkan 10 neonatus dengan hiperbilirubinemia dan 20 neonatus tanpa hiperbilirubinemia. Kadar bilirubin umbilikal pada neonatus dengan hiperbilirubinemia (7,22+7,06 mg/dL) lebih tinggi secara signifikan dibandingkan dengan neonatus tanpa hiperbilirubinemia (3,33+1,82 mg/dL) (p=0,003). Nilai cut off bilirubin umbilikal untuk hiperbilirubinemia adalah >3,78 mg/dL dengan sensitivitas 90%, spesifisitas 80%, dan risiko relatif (RR) 11,769; (IK 95% 1,699- 81,545).Kesimpulan. Kadar bilirubin umbilikal dapat digunakan sebagai prediktor hiperbilirubinemia dengan nilai cut off untuk hiperbilirubinemia adalah >3,78 mg/dL.

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