Correlation of COPD and Metabolic syndrome and role of serum CRP level as a marker of systemic inflammation

Abstract

Introduction: -Chronic obstructive pulmonary disease (COPD) has effects that seems to be related with systemic inflammation. The objective of the current study was to find the relationship of metabolic syndrome and C-reactive protein (CRP) levels, as a marker of systemic inflammation in stable COPD patients with different severity levels and in age and sex matched control group .Materials and Methods:-100 stable COPD patients and 50 control subjects were included in the study. The severity level in patients with COPD were determined according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria. ATP III (The National Cholesterol Education Program’s Adult Treatment Panel III) was used in diagnosis of metabolic syndrome. Hs-CRP levels were measured in venous samples of patients and control subjects. Results: - The frequency of metabolic syndrome was found higher in-patient group than control subjects, especially in GOLD stages I, II (p= 0.004). Abdominal obesity, hypertension, hyperglycaemia components of metabolic syndrome were significantly more prevalent in-patient group (p< 0.0001). Increased CRP levels were higher in control and patient groups in all GOLD stages, with metabolic syndrome than without metabolic syndrome (p= 0.046, p= 0.216, p< 0.001, p= 0.05, p= 0.466).