Correlation of clinical course and value of SCC-antigen in serum of patients with oral cancer.

Kamiya, Yûji; Shimozato, Kazuo; Ikeda, Noriaki; Iida, Susumu; Komaki, Kanji; Fukano, Hideo; Oiwa, Ichiro; Ochiai, Shigeki; Nakamura, Tomoyasu; Sako, M.; Kawai, Takeshi

doi:10.5794/jjoms.35.1292

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“…31 The clinical usefulness of serum SCC antigen as a marker for oral squamous cell carcinoma has often been reported since the publication of the Kato et al study; but, the positive rates differ among investigators. 4,19,32,33 The positive rate for serum S C C antigen in this study was relatively low; but the positive rate for plasma GST-Jr Kobayashi et al…”

Section: Discussionmentioning

confidence: 98%

Evaluation of plasma glutathione S-transferase-π (GST-π) as a tumor marker for oral squamous cell carcinoma

et al. 1996

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Background: This study estimates the usefulness of plasma GST-z:as a tumor marker for oral squamous cell carcinoma. Methods:In a preliminary study, the plasma and serum GST-zrlevels were measured and compared. The positive rate for GST-rc was 52.7% in plasma and 20.0% in serum. Thus the plasma GST-zr was determined to be more sensitive and a useful tumor marker. Plasma GST-zc levels were measured in untreated oral carcinoma cases, recurrent oral carcinoma cases, oral leukoplakia cases and healthy controls. Results:The positive rate was 57.1% in untreated carcinoma cases, 60.5% in recurrent carcinoma cases, 0.0% in leukoplakia cases. As for the untreated carcinoma cases, site, size, clinical stage, lymph node metastasis, and histopathological grading (WHO) were examined; but no relationship between plasma GST-~ levels and each of these factors was found. The positive rates for plasma GST-zcwere compared with those for serum SCC antigen. The plasma GST-zc showed a significantly higher positive rate and was considered more useful. Plasma GST-zc levels tended to regress into a normal range after treatment. But in those patients with recurrence regression of plasma GST-rc levels did not occur. Conclusion:Plasma GST-zc is considered clinically reliable and useful in the diagnosis of oral squamous cell carcinoma and early detection of recurrence or metastasis.

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