Correlation of clinical and radiological predictors of retinoblastoma with high‐risk histopathological features

Yaqoob, Nausheen; Zia, Nida; Hamid, Ahmer; Kaleem, Bushra; Jamal, Saad; Amin, Saima; Qaddoumi, Ibrahim; Jamal, Saba

doi:10.1002/pbc.29625

Cited by 2 publications

(2 citation statements)

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“…Factors that may affect eye preservation include eye‐preserving therapy, IIRC groups and various clinical risk factors, such as retinal detachment, corneal edema, anterior chamber haemorrhage and iris neovascularization. (Yaqoob et al, 2022) With growing experience and an increasing number of treatments, several complications have been reported. Retinoblastoma rarely presents with vitreous haemorrhage, and conversely, degradation of vitreous haemorrhage due to any cause can be misdiagnosed as retinoblastoma in a minority of cases.…”

Section: Discussionmentioning

confidence: 99%

Does vitreous haemorrhage and calcification lead to increased risk of enucleation in advanced retinoblastoma?

Yang

Jia

et al. 2023

Acta Ophthalmologica

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PurposeTo explore whether varying degrees of vitreous haemorrhage (VH) and calcification act as risk factors for enucleation in patients with advanced retinoblastoma (RB).MethodsAdvanced RB was defined by the international classification of RB (Philadelphia version). Basic information for retinoblastoma patients diagnosed as groups D and E in our hospital between January 2017 and June 2022 was reviewed by logistics regression models. Additionally, a correlation analysis was performed, excluding variables with a VIF (variance inflation factor) >10 from the multivariate analysis.ResultsA total of 223 eyes diagnosed with RB were included in assessing VH and calcification; of these, 101 (45.3%) eyes experienced VH, and 182 (76.2%) eyes were found to have calcification within the tumour through computed tomography (CT) or B‐scan ultrasonography. Ninety‐two eyes (41.3%) were enucleated, of which 67 (72.8%) had VH and 68 (73.9%) calcification, both of which were significantly relevant to enucleation (p < 0.001*). Other clinical risk factors, such as corneal edema, anterior chamber haemorrhage, high intraocular pressure during treatment and iris neovascularization, correlated significantly with enucleation (p < 0.001*). Multivariate analysis included IIRC (intraocular international retinoblastoma classification), VH, calcification and high intraocular pressure during treatment as independent risk factors for enucleation.ConclusionsDespite identifying different potential risk factors for RB, there remains significant controversy concerning which patients require enucleation, and the degree of VH varies. Such eyes need to be evaluated carefully, and management with appropriate adjuvant therapy may improve the outcome of these patients.

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Section: Discussionmentioning

confidence: 99%

Does vitreous haemorrhage and calcification lead to increased risk of enucleation in advanced retinoblastoma?

Yang

Jia

et al. 2023

Acta Ophthalmologica

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“…Yaqoob et al found that among 54 patients, the main histopathological traits included choroidal invasion, observed in 18 patients, along with the anterior invasion of the optic nerve anterior to the lamina cribrosa, observed in 16 patients. Through association analysis, the researchers also found that clinical features such as pseudohypopyon, iris neovascularization, buphthalmos, and glaucoma were associated with choroidal infiltration [ 110 ]. Additionally, Kashyap et al also highlighted correlations between features such as glaucoma and iris neovascularization and the incidence of high-risk histopathological findings [ 111 ].…”

Section: Pathology Of Rbmentioning

confidence: 99%

Molecular Biological Research on the Pathogenic Mechanism of Retinoblastoma

Ma,

Li,

Sun

et al. 2024

CIMB

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Retinoblastoma (RB) is the most common intraocular malignant tumor in children, primarily attributed to the bi-allelic loss of the RB1 gene in the developing retina. Despite significant progress in understanding the basic pathogenesis of RB, comprehensively unravelling the intricate network of genetics and epigenetics underlying RB tumorigenesis remains a major challenge. Conventional clinical treatment options are limited, and despite the continuous identification of genetic loci associated with cancer pathogenesis, the development of targeted therapies lags behind. This review focuses on the reported genomic and epigenomic alterations in retinoblastoma, summarizing potential therapeutic targets for RB and providing insights for research into targeted therapies.

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Correlation of clinical and radiological predictors of retinoblastoma with high‐risk histopathological features

Cited by 2 publications

References 44 publications

Does vitreous haemorrhage and calcification lead to increased risk of enucleation in advanced retinoblastoma?

Does vitreous haemorrhage and calcification lead to increased risk of enucleation in advanced retinoblastoma?

Molecular Biological Research on the Pathogenic Mechanism of Retinoblastoma

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