Correlation of circulating miRNA-146a-5p and let-7b expression with thyroid-stimulating hormone receptor antibody in patients with graves disease

Al-Heety, Rashad Ayad; AL-Hadithi, Hayfaa S.; Turki, Kismat M.

doi:10.1016/j.genrep.2020.100608

Cited by 6 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggess that the main mechanism by which miR-142-3p contributes to GD pathogenesis involves the production of TSHR-Ab which in turn causes the production of FT3 and FT4. This result is in agreement with a study that reported that some miRNAs are positively correlated with TSHR-Abs and associated with the development of GD (27). The positive correlation of miR-142-3p with TSHR-Abs may be due to that miR-142-3p was involved in the inflammatory pathways such as B-cell receptor signaling pathway and TNF-signaling pathway, which is responsible for the production of antibody and in turn resulting in its positive correlation with FT3 and FT4.…”

Section: Correlation Of Mir-142-3p Expression Level With Tshr-absupporting

confidence: 94%

Association of Circulating MicroRNA-142-3p with Graves Disease

Al-Heety

AL-Hadithi

2021

Baghdad Sci.J

View full text Add to dashboard Cite

This study aims to investigate the possible role of circulating microRNA-142-3p (miR-142-3p) in thedevelopment of graves disease (GD) and its association with the antibody directed against thyroidstimulating hormone receptor (TSHR-Ab) production in patients with GD. Forty patients with positiveTSHR-Ab enrolled in this study were divided ,based on treatment, into (22 untreated (newly diagnosed) and18 treated patients) and based on family history (30 with positive family history and 10 with negative familyhistory). In addition to forty healthy subjects with sex and age matching as a control group. The expressionlevel of circulating miR-142-3p was determined by two steps reverse transcription polymerase chain reaction(RT-PCR) technique. Results show that there is a significant elevation (p < 0.01) in the expression of miR-142-3p in the serum of both treated and untreated patients compared with controls and in patients withpositive family history compared with negative family history. While its expression is non-significantlylower (P > 0.05) in the serum of treated patients compared with untreated ones. It has been found that miR-142-3p expression was positively correlated with levels of TSHR-Ab, FT3, and FT4. In addition, the miR-142-3p expression has a good diagnostic accuracy with sensitivity (82%) and specificity (80%). Inconclusion, the differential expression of miR-142-3p between patients and healthy controls appears as apotential biomarker for diagnosis of GD and the positive correlation of miR-142-3p with TSHR-Absuggesting the contribution of this miRNA in the development of GD.

show abstract

Section: Correlation Of Mir-142-3p Expression Level With Tshr-absupporting

confidence: 94%