Correlation of Circulating Antisperm Antibodies to Functional Success in Vasovasostomy

Sullivan, Michael J.; Howe, Gerald E.

doi:10.1016/s0022-5347(17)58393-7

Cited by 63 publications

(9 citation statements)

References 9 publications

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“…Only 2 conceptions occurred with positive tests (N=26) against 9 in the negative group (N=20). These results show a significant difference (P< 0.01) and confirm the observation of Sullivan and Howe (1977). In 3 patients a positive pre-operative test reverted to negative after vasectomy reversal.…”

Section: Circulating Sperm Antibodiessupporting

confidence: 84%

Factors Influencing the Outcome of Vasectomy Reversal

Bagshaw

Masters

Pryor

1980

British Journal of Urology

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Fifty-six vasectomy reversals performed during the period 1976 to 1978 have been reviewed with reference to factors which might influence the outcome. Spermatozoa appeared in the ejaculate in 51 (91%) and remained in numbers greater than 10 million per ejaculate in 35 (63%). The wives of 14 men conceived. The following factors have been shown to be associated with a favourable result: a short delay between vasectomy and its reversal, a short previously resected segment, opalescent fluid from the cut lower end of the vas and the absence of circulating antisperm antibodies. A substantially higher conception rate was achieved when the husband had remained with his original partner. Sixty-two testicular biopsies obtained at the time of vasectomy reversal were examined by light microscopy and showed no gross impairment of spermatogenesis. Immunofluorescent techniques failed to show the presence of antigen antibody complexes in 36 testicular biopsies and in 12 vasal stumps.

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Section: Circulating Sperm Antibodiessupporting

confidence: 84%

Factors Influencing the Outcome of Vasectomy Reversal

Bagshaw

Masters

Pryor

1980

British Journal of Urology

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“…The hypothesis that some cases of infertility have an immunological basis is plausible because vasectomy results in a high incidence of circulating autoantibody directed against sperm (1), and infertility after vasovasostomy is correlated with sperm agglutinins in serum (3) and semen (4). Infertility in vasovasostomized rhesus monkeys is also correlated with a high titer of circulating antibody to sperm (5).…”

Section: Tomy In Menmentioning

confidence: 99%

Autoantibodies from Vasectomized Guinea Pigs Inhibit Fertilization in Vitro

Huang

Tung

Yanagimachi

1981

Science

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Immunoglobulin G and Fab antibodies were isolated from the serum of vasectomized guinea pigs, and the effects of the antibodies on fertilization in vitro were investigated. These antibodies had profound inhibitory effects on (i) sperm-to-sperm adhesion, (ii) the acrosome reaction, (iii) sperm-zona binding, and (iv) sperm-ovum fusion. This finding may explain certain cases of infertility after vasovasostomy in men.

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“…Antisperm antibodies develop in the serum of 60-80% of men following vasectomy [34, 351 but their effects on fertility following vasectomy reversal are poorly understood. Sullivan and Howe [80] found antibodies in the sera of 48% of men whose female partners were pregnant and 94% of those whose female partners were not pregnant, suggesting some relationship between these factors. The present authors found antibodies in the sera of 79% of 130 men presenting for vasectomy reversal: antibodies were found in seminal plasma in 9.5% of men before, rising to 29.5% after vaso-vasostomy [81].…”

Section: Vasectomy Reversalmentioning

confidence: 99%

Vasectomy and vasectomy reversal

Hendry

1994

British Journal of Urology

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Vasectomy remains the safest method of birth control and there is much to commend it in the setting of a stable family relationship. However, some aspects of this operation have been wrongly presented in an attempt to widen its popularity and increase public acceptance. A simple procedure it may be but it is not totally free of complications; sometimes the operation has to be repeated and rarely it may reverse spontaneously even after the most stringent precautions. The family planning officer who counsels a prospective candidate and the surgeon who undertakes the procedure must ensure that these facts are understood by the patient with crystal clarity and that this fact is duly recorded on a signed and witnessed permission slip. Any organization which includes vasectomy in its programme of family planning should include advice and referral for vasectomy reversal in exactly the same way that the pill may be stopped or a coil can be removed. Fertility can be successfully restored by vasovasostomy in 50% of men who wish to have their vasectomies reversed, which often is due to a change in circumstances beyond their direct control.

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Correlation of Circulating Antisperm Antibodies to Functional Success in Vasovasostomy

Cited by 63 publications

References 9 publications

Factors Influencing the Outcome of Vasectomy Reversal

Factors Influencing the Outcome of Vasectomy Reversal

Autoantibodies from Vasectomized Guinea Pigs Inhibit Fertilization in Vitro

Vasectomy and vasectomy reversal

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