Correlation of chest CT severity score with clinical parameters in COVID-19 pulmonary disease in a tertiary care hospital in Delhi during the pandemic period

Abstract

Background Since November 2019, the rapid outbreak of coronavirus disease 2019 (COVID-19) has become a public health emergency of international concern. COVID-19 disease is caused by a new variant of coronavirus, named as ‘severe acute respiratory syndrome coronavirus 2.’ Chest CT has a potential role in the diagnosis, detection of complications and in predicting clinical recovery of patients or progression of coronavirus disease 2019. Degree and severity of lung involvement can be assessed by 25 point CT severity score. This quantification plays an important role to modify the treatment plan at times in critically ill patient of COVID-19. Hence, the purpose of present study was to describe and quantify the severity of COVID-19 infection on chest computed tomography (CT) by 25-point CT severity score and to determine the relationship of CT severity score with clinical and laboratory parameters. Results A total of 150 patients with COVID-19 disease were assessed. Mean age of the study group was 54.46 years (62.7% males and 37.3% females). The most common comorbidity present in the study group was diabetes mellitus, which was present in 17.3% cases. Severity of disease was significantly associated with age of the patient. CT severity score was positively correlated with lymphopenia and raised CRP, D-dimer and serum ferritin levels. A significant statistical correlation was found between CT severity grade and patient survival. Conclusions This is a large comprehensive study, collecting data from 150 cases of COVID-19 pneumonia patients, in a tertiary care hospital in India to describe the correlation of CT severity score with clinical land laboratory parameters. Chest CT severity score correlates well with laboratory parameters and can aid in predicting COVID-19 disease outcome.

A study on diagnostic and prognostic significance of laboratory parameters and its correlation with HRCT of lung in Covid-19 patients

“…2 In the present study, TLC was increased in 35% of cases and showed a positive correlation (r=0.07) with CT severity score. Similar studies done by Sharma S. et al 3 and Agarwal N et al 4 showed increased TLC count in 48.7% and 39.03% respectively, concluding a rising trend of leukocyte counts with increasing disease severity.…”

“…25) with CT severity score. Similar studies have been done by various other authors, Sharma S. et al, 3 Ahmad Z et al 6 , Xie Y et al 7 Agarwal N et al, 4 Chandran J et al 5 indicating that when the absolute lymphocyte count decreases, the patient's condition also deteriorates.…”

“…This may be due to differences in the timing of investigations. Sharma S. et al 3 Lonsane A et al 18 Francone M et al 19 showed statistically significant correlation between CT score vs CRP (p < 0.0001, r = 0.6204). Tan C. et al 20 reported that CRP in severe patients increased significantly at the initial stage of the disease and CRP predicted early Covid-19 disease.…”

“…Various authors also studied these and reported similar findings. They are Padiya G S et al, 11 Kömürcüoglu B et al, 12 Sharma S. et al, 3 Vidyashree S et al, 13 Gupta P et al, 14 Padiya G S et al 11 did a study on 59 patients which included 21 patients in the mild group,31 in the moderate group, and 7 in the severe group. CT severity score was found to be positively correlated with ferritin levels (p < 0.001).…”

De Novo Lower Urinary Tract Symptoms in COVID-19 Patients

“…The patients were then classified into three groups according to their severity based on the OAB symptom scoring system, as follows: 3-5: mild, 6-11: moderate, and >12: severe (Table 1 ). Similarly, patients were also classified into three groups based on the CT severity scoring system for lung involvement due to COVID-19 infection, as follows: <8/24: mild, 9-15/24: moderate, and >15/24: severe [ 11 ]. The three lung lobes on the right and two lobes on the left were individually assessed, and the percentage involvement of the lobe was noted based on visual assessment.…”