Correlation of chemical acute toxicity between the nematode and the rodent

Li, Yu; Gao, Shan; Jing, Huaiqi; Qi, Lijuan; Ning, Junyu; Tan, Zhiping; Yang, Kexin; Zhao, Chaoying; Ma, Ling; Li, Guojun

doi:10.1039/c3tx50039j

Cited by 27 publications

(30 citation statements)

References 29 publications

(24 reference statements)

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“…While it points to the biocompatible nature of AuNP, we additionally assessed AuNP toxicity in an in vivo C. elegans model. The good correlation of the invertebrates endpoints to rat LD50s 66 and their highly conserved toxicity pathways with humans 67 , make them an excellent model for in vivo whole organism toxicity testing 68 – 70 . Furthermore, it has been shown that C. elegans is a well-suited platform to study the in vivo toxic effects of various types of AuNP 71 , 72 .…”

Section: Discussionmentioning

confidence: 99%

Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms

et al. 2018

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Hindered penetration of antibiotics through biofilms is one of the reasons for the alarming increase in bacterial tolerance to antibiotics. Here, we investigate the potential of laser-induced vapour nanobubbles (VNBs) formed around plasmonic nanoparticles to locally disturb biofilm integrity and improve antibiotics diffusion. Our results show that biofilms of both Gram-negative (Burkholderia multivorans, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria can be loaded with cationic 70-nm gold nanoparticles and that subsequent laser illumination results in VNB formation inside the biofilms. In all types of biofilms tested, VNB formation leads to substantial local biofilm disruption, increasing tobramycin efficacy up to 1-3 orders of magnitude depending on the organism and treatment conditions. Altogether, our results support the potential of laser-induced VNBs as a new approach to disrupt biofilms of a broad range of organisms, resulting in improved antibiotic diffusion and more effective biofilm eradication.

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Section: Discussionmentioning

confidence: 99%

Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms

et al. 2018

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“…From a toxicological perspective this makes C. elegans a very interesting prospect as it allows the metabolic effects of compounds to be incorporated into studies. This was demonstrated by our previous study [ 15 ] that showed the correlation of C. elegans LC50s (24 h) to rat LD50s is similar to the relationship between mouse and rat LD50s ( r = 0.879), and was stronger than the correlation of NHK cell median inhibition concentrations (IC50)s vs. rat LD50s ( r = 0.844). These results indicate that C. elegans may be a valuable model for predicting chemicals’ acute toxicity in rodents.…”

Section: Introductionmentioning

confidence: 62%

Classification and prediction of toxicity of chemicals using an automated phenotypic profiling of Caenorhabditis elegans

Gao

Chen

Zeng

et al. 2018

BMC Pharmacol Toxicol

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BackgroundTraditional toxicological studies have relied heavily on various animal models to understand the effect of various compounds in a biological context. Considering the great cost, complexity and time involved in experiments using higher order organisms. Researchers have been exploring alternative models that avoid these disadvantages. One example of such a model is the nematode Caenorhabditis elegans. There are some advantages of C. elegans, such as small size, short life cycle, well defined genome, ease of maintenance and efficient reproduction.MethodsAs these benefits allow large scale studies to be initiated with relative ease, the problem of how to efficiently capture, organize and analyze the resulting large volumes of data must be addressed. We have developed a new method for quantitative screening of chemicals using C. elegans. 33 features were identified for each chemical treatment.ResultsThe compounds with different toxicities were shown to alter the phenotypes of C. elegans in distinct and detectable patterns. We found that phenotypic profiling revealed conserved functions to classify and predict the toxicity of different chemicals.ConclusionsOur results demonstrate the power of phenotypic profiling in C. elegans under different chemical environments.Electronic supplementary materialThe online version of this article (10.1186/s40360-018-0208-3) contains supplementary material, which is available to authorized users.

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“…In recent years, considerable models have been developed based on the toxicity data of different test organisms and have provided valuable information on the structural features that are important for the toxicity of ILs [15,17,18,35]. Toxicity assays in C. elegans are fast and inexpensive, and previous studies have shown that assay results in C. elegans could be successfully used in predicting chemical activities in mammals [41,42]. This study used the nematode C. elegans as an in vivo animal model for toxicity assay and a QSAR model was constructed based on four molecular descriptors selected by GFA algorithm.…”

Section: Resultsmentioning

confidence: 99%

Toxicity of Selected Imidazolium-based Ionic Liquids on Caenorhabditis elegans: a Quantitative Structure-Activity Relationship Study

Zhang

Chen

et al. 2017

Chinese Journal of Chemical Physics

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Due to the large number of ionic liquids (ILs) and their potential environmental risk, assessing the toxicity of ILs by ecotoxicological experiment only is insufficient. Quantitative structureactivity relationship (QSAR) has been proven to be a quick and effective method to estimate the viscosity, melting points, and even toxicity of ILs. In this work, the LC 50 values of 30 imidazolium-based ILs were determined with Caenorhabditis elegans as a model animal. Four suitable molecular descriptors were selected on the basis of genetic function approximation algorithm to construct a QSAR model with an R 2 value of 0.938. The predicted lgLC 50 in this work are in agreement with the experimental values, indicating that the model has good stability and predictive ability. Our study provides a valuable model to predict the potential toxicity of ILs with different sub-structures to the environment and human health.

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Correlation of chemical acute toxicity between the nematode and the rodent

Cited by 27 publications

References 29 publications

Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms

Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms

Classification and prediction of toxicity of chemicals using an automated phenotypic profiling of Caenorhabditis elegans

Toxicity of Selected Imidazolium-based Ionic Liquids on Caenorhabditis elegans: a Quantitative Structure-Activity Relationship Study

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