Correlation of changes in the red blood cell distribution width with the response to continuous positive airway pressure in patients with obstructive sleep apnea

Lakadamyalı, Hatıce; Kıvanç, Tülay; Avci, Aynur Yilmaz

doi:10.1007/s41105-018-0191-5

Cited by 4 publications

(9 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, surrogate outcomes are often used as read outs because they require long-term research. A list of surrogate outcomes based on available reports was charted out [8,9]. As a result, there were reports on the effects of AHI, sleep stage, ESS, SI, and side effects (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

The Most Effective Amount of Forward Movement for Oral Appliances for Obstructive Sleep Apnea: A Systematic Review

Sakamoto¹,

Furuhashi

Komori

et al. 2019

IJERPH

View full text Add to dashboard Cite

This systematic review clarifies the amount of effective protrusion in mandibular advancement devices of oral appliances required for obstructive sleep apnea (OSA). The systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Review Manager 5 and GRADEpro were used to combine trials and analyze data. The present review included three studies. In mild to moderate OSA cases, measured using the apnea–hypopnea index (AHI), 50% protrusion was more effective than 75% protrusion. However, 75% protrusion was more effective for severe cases. Sleep stage, Epworth Sleepiness Scale (ESS), snoring index, and side effects significantly differed between the groups. Additionally, 75% protrusion was more effective (AHI: 0.38, 95% CI: −0.89 to 1.65, p = 0.56; sleep stage 3: −1.20, 95% CI: 9.54–7.14, p = 0.78; ESS: 1.07, 95% CI: −0.09 to 2.24, p = 0.07; snoring index: 0.09, 95% CI: 0.05–0.13, p < 0.05; side effects: RR: 1.89, 95% CI: 0.36–9.92, p = 0.45). As per the AHI, 75% protrusion was effective in severe cases, whereas 50% protrusion was effective in moderate cases. Analysis of different surrogate outcomes indicated that 75% protrusion was more effective. Further, well-designed, larger trials should determine the benefits for patients. Additionally, investigations of adherence and side effects with long-term follow-up are needed.

show abstract

Section: Resultsmentioning

confidence: 99%

The Most Effective Amount of Forward Movement for Oral Appliances for Obstructive Sleep Apnea: A Systematic Review

Sakamoto¹,

Furuhashi

Komori

et al. 2019

IJERPH

View full text Add to dashboard Cite

show abstract

“…It is uncertain whether continuous positive airway pressure (CPAP) therapy can reduce the RDW while ameliorating OSAS severity [49,55,61,75]. Unfortunately, our search strategy did not identify a sufficient number of studies for analysis, which justifies the conduct of further studies to clarify this issue.…”

Section: Discussionmentioning

confidence: 99%

“…These could alter both blood flow patterns and the interaction with other blood elements and the endothelium, facilitating the development of atherosclerosis [74]. Moreover, the RDW has been associated with an increase in AHI [70] and alterations in ODI and saturation indexes [44][45][46][47][48]52,[55][56][57]60,70].…”

Section: Discussionmentioning

confidence: 99%

“…Of these, 48 were removed because they did not report the studied endpoint (n = 30), did not include the control group (n = 9), investigated pediatric cohorts (n = 4) or different patient groups (n = 2), or were not written in English (n = 3), leaving 17 articles. Since three additional records were identified from Google Scholar and reference lists, a total of 20 manuscripts [14,[44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] were included in the final analysis (Figure 1). The included studies were published between 2012 [44] and 2022 [60][61][62].…”

Section: Systematic Research and Study Characteristicsmentioning

confidence: 99%

“…The included studies were published between 2012 [44] and 2022 [60][61][62]. The majority were conducted in Turkey (n = 15) [14,[44][45][46][47][48]52,54,55,57,58,60,62], whereas the remaining (n = 5) were conducted in Spain [49], Egypt [50], Pakistan [53], China [56], and Romania [61]. Eight studies were retrospective [48,51,52,54,[56][57][58]62] (Table 1).…”

Section: Systematic Research and Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Association between Red Blood Cell Distribution Width and Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis

Lorenzo

Pau

Zinellu

et al. 2023

JCM

View full text Add to dashboard Cite

Although polysomnography is the gold standard method to diagnose obstructive sleep apnea syndrome (OSAS), there is an ongoing quest for simpler and relatively inexpensive biomarkers of disease presence and severity. To address this issue, we conducted a systematic review of the potential diagnostic role of the red blood cell distribution width (RDW), a routine hematological parameter of red blood cell volume variability, in OSAS. A total of 1478 articles were initially identified in the databases PubMed, Web of Science, Scopus, Embase, and Google Scholar, from their inception to February 2023, and 20 were selected for final analysis. The RDW was significantly higher in OSAS than in non-OSAS subjects (SMD = 0.44, 95% CI 0.20 to 0.67, p < 0.001; low certainty of evidence). In univariate meta-regression, the mean oxygen saturation (SpO2) was significantly associated with the effect size. No significant between-group differences were observed in subgroup analyses. Notably, in OSAS subjects, the RDW SMD progressively increased with disease severity. In conclusion, these results suggest that the RDW is a promising biomarker of OSAS (PROSPERO registration number: CRD42023398047).

show abstract

Prevalence of elevated hemoglobin and hematocrit levels in patients with obstructive sleep apnea and the impact of treatment with continuous positive airway pressure: a meta-analysis

et al. 2022

View full text Add to dashboard Cite

Correlation of changes in the red blood cell distribution width with the response to continuous positive airway pressure in patients with obstructive sleep apnea

Cited by 4 publications

References 28 publications

The Most Effective Amount of Forward Movement for Oral Appliances for Obstructive Sleep Apnea: A Systematic Review

The Most Effective Amount of Forward Movement for Oral Appliances for Obstructive Sleep Apnea: A Systematic Review

Association between Red Blood Cell Distribution Width and Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis

Prevalence of elevated hemoglobin and hematocrit levels in patients with obstructive sleep apnea and the impact of treatment with continuous positive airway pressure: a meta-analysis

Contact Info

Product

Resources

About