Correlation of cerebral blood flow velocity and regional cerebral blood flow during word generation

Language lateralization in healthy right-handers

“…fTCD lends itself to determination of hemispheric language dominance. The index of lateralization obtained by fTCD based on word generation is very reliable and closely corresponds to (i) the outcome of the intracarotid amobarbital procedure and (ii) the index of lateralization obtained by fMRI (Deppe et al, 1998;Knecht et al, 1998a). Other techniques like head turning, event-related potentials, transcranial high frequency magnetic stimulation or the dichotic listening test used for the evaluation of language dominance have so far failed to provide results that are reproducible and in sufficient concordance with the intracarotid amobarbital procedure (Bryden and Allard, 1981;Jancke et al, 1992;Jennum et al, 1994;Segalowitz and Berge, 1995;O'Leary et al, 1996;Hugdahl et al, 1997).…”

“…It thus provides an operational index of laterality which, in many respects, resembles the one obtained by the intracarotid amobarbital procedure (Wada test) (Wada and Rasmussen, 1960). Determination of language lateralization by fTCD matches precisely both the results of fMRI and the Wada test with concordance in every single case (Deppe et al, 1998;Knecht et al, 1998a).…”

“…Assessment of hemispheric language dominance was performed by a standardized fTCD technique (used in a number of previous studies) and a word generation task, validated by direct comparison with the intracarotid amobarbital injection and fMRI (Knecht et al, 1996(Knecht et al, , 1997(Knecht et al, , 1998aDeppe et al, 1997Deppe et al, , 1998. Briefly, subjects were presented with a letter on a computer screen 2.5 s after a cueing tone.…”

“…become available (Aaslid, 1987;Hartje et al, 1994;Silvestrini et al, 1994;Rihs et al, 1995). It allows determination of hemispheric dominance in individual subjects in an effective, reliable and non-invasive way (Deppe et al, 1997;Knecht et al, 1998). This technique has now made it possible to establish the variability in the side and degree of language dominance in a representative number of healthy subjects.…”

“…This technique has now made it possible to establish the variability in the side and degree of language dominance in a representative number of healthy subjects. fTCD measures cerebral perfusion changes related to neuronal activation in a way comparable to functional MRI (fMRI) and 15 O-PET (Kuschinsky, 1991;Jueptner and Weiller, 1995;Deppe et al, 1997Deppe et al, , 1998. fTCD makes it possible to compare perfusion changes (by measuring blood flow velocities) within the territories of the two middle cerebral arteries (MCAs), which comprise the potential language areas (van der Zwan and Hillen, 1991).…”