Correlation of CD4/CD8 Ratio with Carotid Intima-Media Layer Thickness in HIV/AIDS Patients at Sanglah General Hospital, Bali, Indonesia

Utama, Susila; Patriawan, Putu; Dewi, Aryanti

doi:10.3889/oamjms.2019.479

Cited by 8 publications

(9 citation statements)

References 15 publications

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“…Regarding the relationship of IMT and immune status, we found a trend towards a lower CD4/CD8 ratio among patients with IMT ≥ 0.9 mm, although the difference did not reach statistical significance. Similar findings have been published previously 8 . Furthermore, we observed that patients with pathological IMT had a lower value of CD4 cells at the time of study inclusion.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of endothelial function and subclinical atherosclerosis in patients with HIV infection

Revillas

González-Quintanilla

Parra

et al. 2021

Sci Rep

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The aim of this study was to analyse the association between human immunodeficiency virus (HIV) related clinical and analytical parameters and the presence of subclinical atherosclerosis as well as endothelial dysfunction. This was a prospective cohort study of HIV-positive patients who underwent intima media thickness (IMT) determination and coronary artery calcium scoring to determine subclinical atherosclerosis. To detect endothelial dysfunction, the breath holding index, flow-mediated dilation and the concentration of endothelial progenitor cells (EPCs) were measured. Patients with an IMT ≥ 0.9 mm had an average of 559.3 ± 283.34 CD4/μl, and those with an IMT < 0.9 mm had an average of 715.4 ± 389.92 CD4/μl (p = 0.04). Patients with a low calcium score had a significantly higher average CD4 cell value and lower zenith viral load (VL) than those with a higher score (707.7 ± 377.5 CD4/μl vs 477.23 ± 235.7 CD4/μl (p = 0.01) and 7 × 104 ± 5 × 104 copies/ml vs 23.4 × 104 ± 19 × 104 copies/ml (p = 0.02)). The number of early EPCs in patients with a CD4 nadir < 350/µl was lower than that in those with a CD4 nadir ≥ 350 (p = 0.03). In HIV-positive patients, low CD4 cell levels and high VL were associated with risk of developing subclinical atherosclerosis. HIV patients with CD4 cell nadir < 350/µl may have fewer early EPCs.

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Section: Discussionsupporting

confidence: 93%

Evaluation of endothelial function and subclinical atherosclerosis in patients with HIV infection

Revillas

González-Quintanilla

Parra

et al. 2021

Sci Rep

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show abstract

“…Regarding the relationship of the IMT and the immunological situation o, we found a tendency to a lower ratio of CD4/CD8 cells among patients with pathological IMT although without statistical signi cance. Similar ndings have been published [8]. In addition, in this study it was observed that patients who presented a pathological IMT had a lower value of CD4 cells at the time of study inclusion.…”

Section: Discussionsupporting

confidence: 91%

“…New analytical and radiological markers are being investigated in order to achieve an earlier diagnosis of atherosclerosis that will allow a more accurate selection of patients who need to perform a primary cardiovascular prophylaxis [6]. Among radiological tests to determinate subclinical atherosclerosis, carotid doppler ultrasound [7][8][9][10] for the measurement of mean intimate thickness (IMT) and coronary artery calcium score [11][12][13] are are the most studied ones in HIV-infected people.…”

Section: Introductionmentioning

confidence: 99%

Subclinical atherosclerosis and endothelial dysfunction in patients with HIV infection: is there any new diagnostic test?

Revillas¹,

González-Quintanilla²,

Parra³

et al. 2021

Preprint

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Introduction: To analyze the association between human immunodeficiency virus (HIV) infection, and the presence of subclinical atherosclerosis and endothelial dysfunction. Methods Prospective cohort study of HIV positive patients who underwent to intimate thickness (IMT) determination and coronary artery calcium score to determine subclinical atherosclerosis. To detect endothelial dysfunction breath holding index, flow mediated dilation and concentration of endothelial progenitor cells (EPC) were measured. Results Patients with an IMT ≥ 0.9 mm had an average of 559.3 ± 283.34 CD4/µl and those with an IMT < 0.9 mm 715.4 ± 389.92 CD4/µl (p = 0.04). Patients with a low calcium score had a significantly higher average of CD4 cells value and lower zenith viral load than those with a higher score (707.7 ± 377.5 CD4/µl vs 477.23 ± 235.7 CD4/µl (p = 0.01)) and (7x104 ± 5x104 c/ml vs 23.4 x 104 ± 19 x 104 c /ml (p = 0.02). Early EPCs concentration in patients with a CD4 nadir < 350/ul was lower than concentration among those presenting a CD4 nadir ≥ 350 (p = 0.03). Conclusion In HIV positive patients low CD4 cells levels and high viral load were associated to a higher risk of developing subclinical atherosclerosis.HIV patients with less CD4 cells may have fewer early EPCs.

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“…different racial compositions, age ranges, treatment types) and a priori risk for cardiovascular disease [4,[17][18][19][20][21][22]. Lower CD4 þ /CD8 þ is associated with greater carotid artery intimal media thickness in people with well controlled HIV [23,24].…”

Section: Discussionmentioning

confidence: 99%

Aging, trends in CD4+/CD8+ cell ratio, and clinical outcomes with persistent HIV suppression in a dynamic cohort of ambulatory HIV patients

Novak

Armon²,

Battalora³

et al. 2022

Aids

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Background: Age blunts CD4 þ lymphocyte cell count/ml (CD4 þ ) improvements observed with antiretroviral therapy (ART)-induced viral suppression among people with HIV (PWH). Prolonged viral suppression reduces immune dysregulation, reflected by risingover time to determine whether it predicts risk for select comorbidities and mortality among aging PWH with viral suppression.Methods: We studied HIV Outpatient Study (HOPS) participants prescribed ART during 2000-2018 who achieved a viral load less than 200 copies/ml on or after 1 January 2000, and remained virally suppressed at least 1 year thereafter. We modeled associations of CD4 þ /CD8 þ with select incident comorbidities and all-cause mortality using Cox regression and controlling for demographic and clinical factors.Results: Of 2480 eligible participants,1145 (46%) were aged less than 40 years, 835 (34%) 40-49 years, and 500 (20%) ! 50 years. At baseline, median CD4 þ /CD8 þ was 0.53 (interquartile range: 0.30-0.84) and similar among all age groups (P ¼ 0.18). CD4 þ /CD8 þ values and percentage of participants with CD4 þ /CD8 þ at least 0.70 increased within each age group (P < 0.001 for all). CD4 þ /CD8 þ increase was greatest for PWH aged less than 40 years at baseline. In adjusted models, most recent CD4 þ / CD8 þ less than 1.00 and less than 0.70 were independently associated with higher risk of non-AIDS cancer and mortality, respectively. Conclusion:Pretreatment immune dysregulation may persist as indicated by CD4 þ /CD8 þ less than 0.70. Persistent viral suppression can improve immune dysregulation over time, reducing comorbidity, and mortality risk. Monitoring CD4 þ /CD8 þ among ART-treated PWH with lower values provide a means to assess for mortality and comorbidity risk.

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Correlation of CD4/CD8 Ratio with Carotid Intima-Media Layer Thickness in HIV/AIDS Patients at Sanglah General Hospital, Bali, Indonesia

Cited by 8 publications

References 15 publications

Evaluation of endothelial function and subclinical atherosclerosis in patients with HIV infection

Evaluation of endothelial function and subclinical atherosclerosis in patients with HIV infection

Subclinical atherosclerosis and endothelial dysfunction in patients with HIV infection: is there any new diagnostic test?

Aging, trends in CD4+/CD8+ cell ratio, and clinical outcomes with persistent HIV suppression in a dynamic cohort of ambulatory HIV patients

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