Correlation of Cardiac Markers and Biomarkers With Blood Pressure of Middle‐Aged Marathon Runners

Abstract

Runners with exercise-induced high blood pressure have recently been reported to exhibit higher levels of cardiac markers, vasoconstrictors, and inflammation. The authors attempted to identify correlations between exercise-related personal characteristics and the levels of biochemical/cardiac markers in marathon runners in this study. Forty healthy runners were enrolled. Blood samples were taken both before and after finishing a full marathon. The change in each cardiac/biochemical marker over the course of the marathon was determined. All markers were significantly (P<.001) increased immediately after the marathon (creatine kinase-MB [CK-MB]: 7.9 ± 2.7 ng/mL, cardiac troponin I (cTnI): 0.06 ± 0.10 ng/mL, N-terminal pro-B-type natriuretic peptide (NT-proBNP): 95.7 ± 76.4, endothelin-1: 2.7 ± 1.16, high-sensitivity C-reactive protein [hs-CRP]: 0.1 ± 0.09, creatine kinase [CK]: 315.7 ± 94.0, lactate dehydrogenase [LDH]: 552.8 ± 130.3) compared with their premarathon values (CK-MB: 4.3 ± 1.3, cTnI: 0.01 ± 0.003, NT-proBNP: 27.6 ± 31.1, endothelin-1: 1.11 ± 0.5, hs-CRP: 0.06 ± 0.07, CK: 149.2 ± 66.0, LDH: 399 ± 75.1). In middle-aged marathon runners, factors related to increased blood pressure were correlated with marathon-induced increases in cTnI, NT-proBNP, endothelin-1, and hs-CRP. These correlations were observed independent of running history, records of finishing, and peak oxygen uptake.

Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation

“…Systolic blood pressure has not been included in the multiple regression analyses in previous studies (10,12,13). However, some smaller studies have reported bivariate correlations between blood pressure and exercise-induced cTn increase (21,22). Our finding is intriguing, and in line with the recent mechanistic study by Weil and al., that observed a transient increase in cTnI following phenylepinephrine infusion in a pig model (7).…”

Galectin-3 and Cardiovascular Biomarkers Reflect Adaptation Response to Scuba Diving

“…Sample size was estimated based on power test analysis through the level of the effects (changes wanted to be observed) taken from previous studies [25,26] for three main outcome variables (NT-proBNP, hs-TnI and Gal-3). Detailed data for sample size estima tion is given in ▶ table 3.…”

Acute and Chronic Effects of Endurance Running on Inflammatory Markers: A Systematic Review

“…Another important confounding factor is the different experience of runners. Thus, 26 studies (4 studies with male and female participants, and 15 studies with only male participants) reported a range of 4–17.5 years of experience with competitions (e.g., marathon, and ultra-marathon experience) (Schobersberger et al, 2000 ; Fallon et al, 2001 ; Nieman et al, 2003 , 2016 ; Suzuki et al, 2003 ; Tomaszewski et al, 2003 ; Kim et al, 2007 , 2015 ; Millet et al, 2011 ; Jee and Jin, 2012 ; Vaisberg et al, 2012 , 2013 ; Waśkiewicz et al, 2012 ; Bernecker et al, 2013 ; Jee et al, 2013 ; Karstoft et al, 2013 ; Kasprowicz et al, 2013 ; Kłapcinska et al, 2013 ; Saugy et al, 2013 ; Shin and Lee, 2013 ; Wilhelm et al, 2014 ; Grabs et al, 2015 ; Hewing et al, 2015 ; Mrakic-Sposta et al, 2015 ; Krzeminski et al, 2016 ; Mohamed et al, 2016 ). However, 25 studies did not report this information (Fehrenbach et al, 2000 ; Mattusch et al, 2000 ; Neidhart et al, 2000 ; Niess et al, 2000 ; Suzuki et al, 2000 ; Bonsignore et al, 2002 ; Uchakin et al, 2003 ; Peters et al, 2004 ; Siegel et al, 2007 ; Ng et al, 2008 ; Papassotiriou et al, 2008 ; Chimenti et al, 2009 , 2010 ; Auersperger et al, 2012 ; Nickel et al, 2012 ; Rehm et al, 2013 ; Santos et al, 2013 ; Bachi et al, 2015 ; Gill et al, 2015b ; Arakawa et al, 2016 ; Nielsen et al, 2016 ; Stuempfle et al, 2016 ; Vernillo et al, 2017 ).…”