Correlation of C-reactive protein and body mass index with diabetic retinopathy in Indian population

Sen, Dipayan; Ghosh, Sambuddha; Roy, Debesh

doi:10.1016/j.dsx.2014.05.004

Cited by 15 publications

(9 citation statements)

References 8 publications

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“…Two cross sectional studies [ 31 , 32 ] and twenty case control studies [ 10 – 16 , 22 – 30 , 33 – 36 ] including a total of 3679 participants were identified in this meta-analysis. A total of 5 studies [ 27 , 28 , 30 , 35 , 36 ] were based on the type 1 DM including 786 participants (case group 142: control group 644), and 17 studies [ 10 – 16 , 22 – 26 , 29 , 31 – 34 ] were based on type 2 DM including 2893 participants (case group 1040: control group 1853). The basic clinical information, characteristics of each study and NOS scores were presented in Tables 1 and 2 .…”

Section: Resultsmentioning

confidence: 99%

“…A sensitivity analysis was used to evaluate the stability and reliability of the results ( Fig 4 ). After removing the studies [ 11 – 13 , 25 , 27 , 30 , 31 , 35 , 36 ] that were contributing most to the heterogeneity, the blood CRP level in the case group was observed to be higher than that in the control group [SMD = 0.23; 95% CI, 0.13itivit ( Fig 5 ). The results did not change substantially before and after removing the studies.…”

Section: Resultsmentioning

confidence: 99%

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Relationship between C-Reactive Protein Level and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

et al. 2015

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ObjectivesTo date, the relationship between C-reactive protein (CRP) level and diabetic retinopathy (DR) remains controversial. Therefore, a systematic review and meta-analysis was used to reveal the potential relationship between CRP level and DR.MethodsA systematic search of PubMed, Embase.com, and Web of Science was performed to identify all comparative studies that compared the CRP level of two groups (case group and control group). We defined that diabetic patients without retinopathy and /or matched healthy persons constituted the control group, and patients with DR were the case group.ResultsTwo cross sectional studies and twenty case control studies including a total of 3679 participants were identified. After pooling the data from all 22 studies, obvious heterogeneity existed between the studies, so a subgroup analysis and sensitivity analysis were performed. Removing the sensitivity studies, the blood CRP levels in the case group were observed to be higher than those in the control group [SMD = 0.22, 95% confidence interval (CI), 0.11–0.34], and the blood CRP levels in the proliferative diabetic retinopathy (PDR) group were also higher than those in the non-proliferative diabetic retinopathy (NPDR) group [SMD = 0.50, 95% CI, 0.30–0.70].ConclusionsThe results from this current meta-analysis indicate that the CRP level might be used as a biomarker to determine the severity of DR.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Relationship between C-Reactive Protein Level and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

et al. 2015

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“…CRP is an important marker of systemic inflammation, which has been physiologically related to atherosclerosis [ 33 ], pre-diabetes, is observed at high concentrations in neuropathic individuals [ 34 ] and correlates with increased macular thickness in patients with diabetic retinopathy [ 35 ]. In this study, we did not find a relationship between CRP, DN and DR, although in the second case, the values were close to the statistical limits of significance.…”

Section: Discussionmentioning

confidence: 99%

Hypermethylation in the promoter of the MTHFR gene is associated with diabetic complications and biochemical indicators

Nunes

Silva

Evangelista

et al. 2017

Diabetol Metab Syndr

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BackgroundDNA methylation is an epigenetic mechanism for regulating the transcription of many genes and has been linked to the development of various diseases. A promising gene to investigate is methylenetetrahydrofolate reductase (MTHFR), since the enzyme methylenetetrahydrofolate reductase (MTHFR) promotes methyl radical synthesis in the homocysteine cycle and can provide methyl groups for DNA methylation. In addition, several studies have correlated gene polymorphisms of this enzyme with a greater risk of diabetes, but little is known regarding the relationship between epigenetic changes in this gene and diabetes and its complications. The aim of this study was to investigate the relationship between methylation profile in the MTHFR gene promoter and biochemical, inflammatory and oxidative stress markers in individuals with type 2 diabetes (T2DM) who have been diagnosed for 5–10 years with or without diabetic retinopathy (DR) and nephropathy (DN).MethodsSpecific PCR for methylation (MSP) was used to analyze MTHFR methylation profile in leucocytes DNA. Biochemical markers (glycemia, glycated hemoglobin, total cholesterol, LDL, HDL, triglycerides, serum creatinine), inflammatory markers (C-reactive protein and alpha-1 acid glycoprotein) and oxidative stress (total antioxidant and malonaldehyde) were determined in peripheric blood samples and microalbuminuria in 24 h urine samples. The X2 and Mann–Whitney statistical tests were performed and p < 0.05 were considered significant.ResultsThe hypermethylated profile was most frequently observed in individuals with retinopathy (p < 0.01) and was associated with higher total cholesterol and LDL levels (p = 0.0046, 0.0267, respectively). Individuals with DN and hypermethylated profiles had higher levels of alpha-1 acid glycoprotein (p = 0.0080) and total antioxidant capacity (p = 0.0169) compared to subjects without complications.ConclusionsHypermethylation in the promoter of the MTHFR gene is associated with the occurrence of DR and with biochemical, inflammatory and oxidative stress parameters in the context of chronic complications

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“…Literature differs in this question and demonstrates a controversy with this association, especially about type 2 DM [23]. Several studies show no association between BMI and DR [18, 21, 31, 36–39] and other positive association [34, 40, 41]. Ahmed et al [28], in a follow-up of involving 977 type 2 DM during 5, 10 and 15 years, did not find an increased risk of DR in any of categories studied.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for diabetic retinopathy: a case–control study

et al. 2016

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BackgroundDiabetic retinopathy (DR) is the major cause of blindness among working age adults. The aim of the study was to investigate risk factors for development of DR.MethodsA case–control study was performed based on data from 240 individuals (80 cases and 160 controls) attending the Outpatient Specialty Clinic of the University of South Santa Catarina (UNISUL), between Mar/2010 and May/2014. Data collection occurred through review of medical charts for presence or absence of DR, determined by an ophthalmologist. Study protocol included demographic characteristics, metabolic control, diabetes mellitus (DM) profile and comorbidities. Statistical analysis used Chi square test for qualitative variables and multivariate logistic regression analysis to select independent variables (SPSS®18.0 software). Odds ratio (OR) was used as measure of association. The study was approved by research ethics committee of UNISUL.ResultsMean age of group case was 59.5 years with a slight female predominance. Gender, age, body mass index were not associated with outcome. Individuals with poor glycemic control were more likely to DR (OR 3.83; 95 % CI 1.57–9.37). It was observed a positive relationship between duration of DM and DR, with higher chances in 11–15 years of disease (OR 7.52, 95 % CI 3.03–18.68) and >15 years (OR 9.01, 95 % CI 3.58–22.66). Regarding comorbidities, only diabetic nephropathy showed higher chance for DR (OR 3.32; 95 % CI 1.62–6.79).ConclusionsDiabetic patients after 10 years of disease with poor glycemic control and nephropathy have a higher chance of DR.

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Correlation of C-reactive protein and body mass index with diabetic retinopathy in Indian population

Cited by 15 publications

References 8 publications

Relationship between C-Reactive Protein Level and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

Relationship between C-Reactive Protein Level and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

Hypermethylation in the promoter of the MTHFR gene is associated with diabetic complications and biochemical indicators

Risk factors for diabetic retinopathy: a case–control study

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