Correlation of bronchoalveolar eosinophilic percentage with airway responsiveness in cats with chronic bronchial disease

Abstract

This study provides supportive evidence of a correlation between airway eosinophilic inflammation and plethysmographic measures of bronchoconstriction and airway responsiveness. Further investigation of the use of barometric whole body plethysmography to differentiate between forms of chronic bronchial disease in cats is indicated.

Clinical features and radiographic findings in cats with eosinophilic, neutrophilic, and mixed airway inflammation (2011‐2018)

“…Cats were categorized as having eosinophilic, mixed, or neutrophilic inflammation based on BAL fluid differential cytology. Previous reports have used eosinophil percentages of >17 to 20 8,15‐18 to define eosinophilic inflammation, and neutrophil percentage exceeding the reference range to describe noneosinophilic or neutrophilic inflammation. Other studies define inflammation based on the prominent cell type.…”

“…Thoracic radiographs were reviewed in masked fashion by a board‐certified radiologist (E.G.J.) using a 0 to 9 scoring system adapted from previously described studies 1,4,15 . Bronchial patterns were scored as follows: 0, absence of a bronchial pattern; 1, mild, first‐generation bronchi visible; 2, moderate, second‐generation bronchi visible; and 3, severe, third‐generation bronchi visible.…”

“…Previous studies evaluating clinical findings in cats with naturally occurring disease have failed to identify clinically relevant differences between cats with asthma and those with chronic bronchitis, with the exception of some investigators noting younger age in cats with airway eosinophilia 1,5,8,13,15 . The purpose of our retrospective study was to investigate clinical variables that could aid in differentiation between inflammatory airway syndromes in a large group of cats with naturally occurring disease in which standardized diagnostic testing, including bronchoscopic bronchoalveolar lavage (BAL), had been performed.…”

Long‐term follow‐up in dogs with idiopathic eosinophilic bronchopneumopathy treated with inhaled steroid therapy

“…) and spontaneous chronic bronchial disease (Allerton et al . ). In dogs, despite its widespread and regular use by clinicians in practice, published clinical response to IST as single therapy in dogs with idiopathic EBP is limited to one case treated with fluticasone (Bexfield et al .…”

“…In cats, IST is also used for the management of experimental asthma (Cohn et al . 2010 ) and spontaneous chronic bronchial disease (Allerton et al . 2013 ).…”