Correlation of boswellic acids with antiproliferative, antioxidant and antimicrobial activities of topographically collected Boswellia serrata oleo-gum-resin

Gupta, Madhuri; Singh, Shilpi; Kurmi, Alka; Luqman, Suaib; Saikia, Dharmendra; Thomas, Moni; Rout, Prasant Kumar

doi:10.1016/j.phyplu.2022.100289

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…The antioxidant activity of AKBA and its derivatives has been reported in previous studies. Gupta et al reported the potent antioxidant activity of Boswellia serrata oleo-gum-resin in their recent study [ 40 ]. CSG4 showed maximum antioxidant activity against DPPH and ABTS cations since AKBA and AgNPs both have significant antioxidant activity against free radicals [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial topical polymeric films loaded with Acetyl-11-keto-β-boswellic acid (AKBA), boswellic acid and silver nanoparticles: Optimization, characterization, and biological activity

Jawad,

Bhatia,

Al-Harrasi

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Antimicrobial topical polymeric films loaded with Acetyl-11-keto-β-boswellic acid (AKBA), boswellic acid and silver nanoparticles: Optimization, characterization, and biological activity

Jawad,

Bhatia,

Al-Harrasi

et al. 2024

Heliyon

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“…In this study, significant difference in antioxidant properties of B. serrata was determined only in GSH levels (P<0.001) (TABLE I). Gupta et al in a study, which they examined the relationship between the antioxidant, antiproliferative and antimicrobial activities of topographically collected B. serrata oleo gum resin and the boswellic acid concentration, showed that the extracts antioxidant activities could be because of the percentage of boswellic acids (BAs) [ 42].…”

Section: Resultsmentioning

confidence: 99%

Effect of Boswellia serrata extract on Methotrexate induced testicular damage

Arkalı,

Acısu,

Badıllı

et al. 2024

RC FCV-LUZ

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This study aimed to determine the effect of Boswellia serrata extract on Methotrexate– induced testicular damage by evaluating antioxidant system, reproductive organ weights, some spermatological parametres and serum Testesterone levels. For this purpose, 40 Sprague Dawley rats were divided into 4 groups. 1. Control Group (n=10): No treatment was given for 10 days. 2. B. serrata Group (n=10): B. serrata was given by gavage at a dose of 500 mg·kg-1 for 10 days. 3. Methotrexate Group (n=10): Methotrexate was given intraperitoneally as a single dose of 20 mg·kg-1. 4. Methotrexate + B. serrata Group (n=10): After methotrexate was given intraperitoneally as a single dose of 20 mg·kg-1, 500 mg·kg-1 B. serrata was given by gavage for 10 days. It was determined that B. serrata significantly increased serum Testosterone levels (P<0.001), testicular GSH levels (P<0.001), motility of sperm (P<0.001), concentration of sperm (P<0.001), absolute ventral prostate (P<0.001) and absolute seminal vesicles (P<0.05) organ weight in Methotrexate + B. serrata group. The decrease in testicular MDA levels (P>0.05) and the increase in GSH–Px enzyme activity of testes (P>0.05) and final body weight (P>0.05) were not significant in Methotrexate + B. serrata group compared to the Methotrexate group. In conclusion, the negative effects of Methotrexate on the male reproductive system can be reduced by administering B. serrata extract.

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“…The values of the antioxidant activity of Boswellia species natural products vary depending on plant species origin and extract type. Expressed by IC50, the antioxidant activity of the methanolic extracts from Boswellia serrata collected from different territories in India was demonstrated to be 2.7-9.9 µg/mL [78]. Essential oil of B. dalzielii leaves showed an IC50 = 6.10 mg/L [50], while for B. carteri was recorded at 0.64 µL/mL [79].…”

Section: Antimicrobial Activitymentioning

confidence: 98%

Boswellia Essential Oil: Natural Antioxidant as an Effective Antimicrobial and Anti-Inflammatory Agent

Obiștioiu,

Hulea,

Cocan

et al. 2023

Antioxidants

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The research aimed to determine the chemical composition, the antioxidant and anti-inflammatory activity as well as the antimicrobial activity against Gram-positive, Gram-negative and two fungal Candida ATCC strains of a commercial Boswellia essential oil (BEO) containing Boswellia carteri, Boswellia sacra, Boswellia papryfera, and Boswellia frereana. Additionally, molecular docking was carried out to show the molecular dynamics of the compounds identified from the essential oil against three bacterial protein targets and one fungal protein target. The major components identified by GC-MS (Gas Chromatography-Mass Spectrometry) were represented by α-pinene, followed by limonene. Evaluation of antioxidant activity using the DPPH (2,2-Diphenyl-1-Picrylhydrazyl) method showed high inhibition comparable to the synthetic antioxidant used as a control. Oxidative stability evaluation showed that BEO has the potential to inhibit primary and secondary oxidation products with almost the same efficacy as butylated hydroxyanisole (BHA). The use of BEO at a concentration of 500 ppm provided the best protection against secondary oxidation during 30 days of storage at room temperature, which was also evident in the peroxide value. Regarding the in vitro anti-inflammatory activity, the membrane lysis assay and the protein denaturation test revealed that even if the value of protection was lower than the value registered in the case of dexamethasone, the recommendation of using BEO as a protective agent stands, considering the lower side effects. Gram-positive bacteria proved more sensitive, while Pseudomonas aeruginosa presented different sensitivity, with higher MICs (minimal inhibitory concentration). Haemophilus influenzae demonstrated a MIC at 2% but with consecutive inhibitory values in a negative correlation with the increase in concentration, in contrast to E. coli, which demonstrated low inhibitory rates at high concentrations of BEO. The computational tools employed revealed interesting binding energies with compounds having low abundance. The interaction of these compounds and the proteins (tyrosyl-tRNA synthetase, DNA gyrase, peptide deformylase, 1,3-β-glucan synthase) predicts hydrogen bonds with amino acid residues, which are reported in the active sites of the proteins. Even so, compounds with low abundance in BEO could render the desired bioactive properties to the overall function of the oil sustained by physical factors such as storage and temperature. Interestingly, the findings from this study demonstrated the antioxidant and antimicrobial potential of Boswellia essential oil against food-related pathogens, thus making the oil a good candidate for usage in food, feed or food-safety-related products.

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Correlation of boswellic acids with antiproliferative, antioxidant and antimicrobial activities of topographically collected Boswellia serrata oleo-gum-resin

Cited by 8 publications

References 21 publications

Antimicrobial topical polymeric films loaded with Acetyl-11-keto-β-boswellic acid (AKBA), boswellic acid and silver nanoparticles: Optimization, characterization, and biological activity

Antimicrobial topical polymeric films loaded with Acetyl-11-keto-β-boswellic acid (AKBA), boswellic acid and silver nanoparticles: Optimization, characterization, and biological activity

Effect of Boswellia serrata extract on Methotrexate induced testicular damage

Boswellia Essential Oil: Natural Antioxidant as an Effective Antimicrobial and Anti-Inflammatory Agent

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