Correlation of bone marrow 2-deoxy-2-[18F]fluoro-D-glucose uptake with systemic inflammation in patients with newly diagnosed endometrial cancer

Abstract

Objective To clarify the relationship between 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake of bone marrow and systemic inflammation in patients with newly diagnosed endometrial cancer. Methods A total of 119 patients with untreated endometrial cancer underwent FDG PET/computed tomography (CT). For bone marrow FDG uptake, the mean standardized uptake value (SUVmean) of the five vertebrae (T11-12 and L3-L5) was measured and averaged (bone marrow SUV). The bone marrow-to-liver ratio (BLR) was calculated by dividing the bone marrow SUV by the SUVmean of the normal liver. FDG PET parameters were correlated with white blood cell count, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-reactive protein (CRP), albumin, and hemoglobin levels. They were also correlated with FIGO stage. Results Bone marrow SUV and BLR showed significant positive correlations with white blood cell count, NLR, and CRP level and significant negative correlations with albumin level. BLR also showed a significant positive correlation with PLR. No significant differences in bone marrow SUV and BLR were apparent according to FIGO stage. Conclusion Pretreatment FDG PET/CT in patients with newly diagnosed endometrial cancer may provide information on host systemic inflammation as assessed by bone marrow FDG uptake.

Role of splenic and bone marrow uptake at 18F‐FDG PET/CT for the assessment of large vessels vasculitis and the influence of glucocorticoids therapy on their values

“…21 Interestingly, splenic uptake has demonstrated a predictive role for clinical outcomes in patients with rectal cancers and that, in neoplastic patients, the presence of increased 18 F-FDG uptakes in the spleen or BM are related to the presence of systemic inflammation. [24][25][26][27] The pieces of evidence on the value of high metabolic activity in these structures for the evaluation of concomitant diseases are therefore increasing.…”

“…Furthermore, it has been reported that vascular inflammation is associated with high tracer uptake of haematopoietic organs 19 and that, in patients with psoriasis, it is linked with uptake in spleen and BM at 18 F‐FDG PET/CT 21 . Interestingly, splenic uptake has demonstrated a predictive role for clinical outcomes in patients with rectal cancers and that, in neoplastic patients, the presence of increased 18 F‐FDG uptakes in the spleen or BM are related to the presence of systemic inflammation 24–27 . The pieces of evidence on the value of high metabolic activity in these structures for the evaluation of concomitant diseases are therefore increasing.…”

Relationship of FDG Uptake of the Reticuloendothelial System with Tumor Immune Microenvironment and Prognosis in Patients with Gastric Cancer

“…In a previous study, patients with malignant disease showed significantly increased FDG uptake in the bone marrow (BM) and spleen, which are the major organs of the reticuloendothelial system that play a crucial role in the host inflammatory response to cancer cells [ 15 , 16 , 17 ]. Moreover, a number of studies have demonstrated that FDG uptake in the BM and spleen showed significant correlations with serum inflammatory markers, including NLR and PLR, and patients with high FDG uptake in the BM and spleen had significantly worse clinical outcomes than those with low uptake in various kinds of malignant diseases [ 14 , 18 , 19 , 20 ]. Therefore, FDG uptake in the BM and spleen has been suggested as an imaging biomarker of PET/CT to estimate the host systemic inflammatory response to cancer cells [ 19 , 20 ].…”

“…Moreover, a number of studies have demonstrated that FDG uptake in the BM and spleen showed significant correlations with serum inflammatory markers, including NLR and PLR, and patients with high FDG uptake in the BM and spleen had significantly worse clinical outcomes than those with low uptake in various kinds of malignant diseases [ 14 , 18 , 19 , 20 ]. Therefore, FDG uptake in the BM and spleen has been suggested as an imaging biomarker of PET/CT to estimate the host systemic inflammatory response to cancer cells [ 19 , 20 ]. However, until now, there are no studies that compared the relationship of FDG uptake of both BM and spleen with the tumor immune microenvironment in a single study [ 14 , 21 , 22 , 23 ].…”