Correlation of Blood Type with the Presence of IgE Antibodies to Galactose-alpha-1,3-galactose (Alpha-gal): Is there a Protective Effect of Blood Group Substance B?

Posthumus, Jonathon; James, H.; Wang, X.; Commins, Scott P.; Platts‐Mills, Thomas A.E.

doi:10.1016/j.jaci.2009.12.795

Cited by 3 publications

(5 citation statements)

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“…Among the factors suggested to be involved, the B or AB blood group have been correlated with lower levels of anti-gal antibodies and might be less prone to IgE immunisation. 22 However, in this study we did not observe any correlation between the blood group and the level of anticetuximab IgE in patients or control groups (data not shown).…”

Section: Patient Characteristics and Hsrs Between October 2005 Tocontrasting

confidence: 55%

Anti-cetuximab IgE ELISA for identification of patients at a high risk of cetuximab-induced anaphylaxis

Mariotte

Dupont²,

Gervais

et al. 2011

mAbs

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Cetuximab, a chimeric mouse-human IgG1 monoclonal antibody against the epidermal growth factor receptor, has proven effective in the treatment of metastatic colorectal cancer and squamous cell carcinoma of the head and neck. However, a high incidence of immediate hypersensitivity reactions (HSR) to cetuximab after the first infusion has been observed. We have developed a test for identification of patients likely to show treatment-related HSR to cetuximab. An enzyme-linked immunosorbent assay (ELISA) for detecting anti-cetuximab IgEs was developed and tested on serum samples collected from cancer patients before start of cetuximab treatment, and from healthy blood donors. Similar levels of anti-cetuximab IgE were detected in pre-treatment patient sera (24/92, 26.1%) and sera from healthy blood donors (33/117, 28.2%). HSR were observed in 14 out of the 92 patients (15.2%), and 8 of these (57.1%) were grade 3-4. Anti-cetuximab IgEs were detected in 7/8 of the patients (87.5%) with severe HSRs as compared with 14/78 patients (17.9%) with no HSR (p=0.0002). Predictive value of the anti-cetuximab IgE test for HSR events of grades 3-4 was calculated using Receiver Operating Characteristics analysis. With a cut-off value of 29 arbitrary units for the anti-cetuximab IgE, the ELISA test showed a sensitivity of 87.5%, specificity of 82.1%, positive predictive value of 33.3% and negative predictive value of 98.5%. Anti-cetuximab IgE ELISA detection could be a valuable tool to help the physician anticipate an anaphylaxis episode following cetuximab infusion and opt for a suitable alternative treatment.

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Section: Patient Characteristics and Hsrs Between October 2005 Tocontrasting

confidence: 55%

Anti-cetuximab IgE ELISA for identification of patients at a high risk of cetuximab-induced anaphylaxis

Mariotte

Dupont²,

Gervais

et al. 2011

mAbs

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“…In a study conducted in Sweden, people with blood type B negative were affected by the a-gal allergy more often than other blood types . However, this trend contradicts the hypothesis that a protective effect is produced by blood type B (Posthumus et al, 2010). Intriguingly, this relationship seems to be related to the similarities between agal and blood type B antigen (Gal-a1,3 (Fuc-a1,2)-Gal) structures (Posthumus et al, 2010;Bircher et al, 2017).…”

Section: Host and Tick Factors Contributing To Agsmentioning

confidence: 78%

“…However, this trend contradicts the hypothesis that a protective effect is produced by blood type B (Posthumus et al, 2010). Intriguingly, this relationship seems to be related to the similarities between agal and blood type B antigen (Gal-a1,3 (Fuc-a1,2)-Gal) structures (Posthumus et al, 2010;Bircher et al, 2017). examined the allergy incidence rates, whereas Posthumus et al (2010) assessed IgE production in affected individuals.…”

Section: Host and Tick Factors Contributing To Agsmentioning

confidence: 95%

“…Intriguingly, this relationship seems to be related to the similarities between agal and blood type B antigen (Gal-a1,3 (Fuc-a1,2)-Gal) structures (Posthumus et al, 2010;Bircher et al, 2017). examined the allergy incidence rates, whereas Posthumus et al (2010) assessed IgE production in affected individuals. These studies further suggest there is a need for more in-depth research to elucidate the AGS onset mechanisms.…”

Section: Host and Tick Factors Contributing To Agsmentioning

confidence: 99%

“… Hamsten et al. (2013) examined the allergy incidence rates, whereas Posthumus et al. (2010) assessed IgE production in affected individuals.…”

Section: Host and Tick Factors Contributing To Agsmentioning

confidence: 99%

See 2 more Smart Citations

Tick Saliva and the Alpha-Gal Syndrome: Finding a Needle in a Haystack

Sharma

Karim

2021

Front. Cell. Infect. Microbiol.

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Ticks and tick-borne diseases are significant public health concerns. Bioactive molecules in tick saliva facilitate prolonged blood-feeding and transmission of tick-borne pathogens to the vertebrate host. Alpha-gal syndrome (AGS), a newly reported food allergy, is believed to be induced by saliva proteins decorated with a sugar molecule, the oligosaccharide galactose-⍺-1,3-galactose (α-gal). This syndrome is characterized by an IgE antibody-directed hypersensitivity against α-gal. The α-gal antigen was discovered in the salivary glands and saliva of various tick species including, the Lone Star tick (Amblyomma americanum). The underlying immune mechanisms linking tick bites with α-gal-specific IgE production are poorly understood and are crucial to identify and establish novel treatments for this disease. This article reviews the current understanding of AGS and its involvement with tick species.

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