Correlation of blood high mobility group box-1 protein with mortality of patients with sepsis: A meta-analysis

Cai, Jingjing; Lin, Zhuandi

doi:10.1016/j.hrtlng.2021.07.010

Cited by 8 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pathologically, these proteins are released from damaged or activated cells and play pro-inflammatory and procoagulant roles in DIC development [ 8 ]. Clinically, serum HMGB1 and histone H3 levels in patients with sepsis and acute leukemia were elevated in non-survivors [ 9 – 13 ]. In addition, the elevation of serum HMGB1 and histone H3 levels was found in patients with DIC and in patients with organs failure [ 10 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of plasma high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study

et al. 2022

View full text Add to dashboard Cite

Background We compared the prognostic value of serum high mobility group box 1 protein (HMGB1) and histone H3 levels with the International Society on Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation (DIC) scores for 28-day in-hospital mortality in patients with DIC caused by various underlying diseases. Methods We conducted a multicenter prospective cohort study including two hematology departments, four emergency departments, and one general medicine department in Japan, between August 2017 and July 2021. We included patients diagnosed with DIC by the ISTH DIC scoring system. Results Overall, 104 patients were included: 50 with hematopoietic disorders, 41 with infections, and 13 with the other diseases. The 28-day in-hospital mortality rate was 21%. The receiver operator characteristic (ROC) curve showed that a DIC score of 6 points, serum HMGB1 level of 8 ng/mL, and serum histone H3 level of 2 ng/mL were the optimal cutoff points. The odds ratios of more than these optimal cutoff points of the DIC score, serum HMGB1, and histone H3 levels were 1.58 (95% confidence interval [CI]: 0.60 to 4.17, p = 0.36), 5.47 (95% CI: 1.70 to 17.6, p = 0.004), and 9.07 (95% CI: 2.00 to 41.3, p = 0.004), respectively. The area under the ROC curve of HMGB1 (0.74, 95% CI: 0.63 to 0.85) was better than that of the ISTH DIC scores (0.55, 95% CI: 0.43 to 0.67, p = 0.03), whereas that of histone H3 was not (0.71, 95% CI: 0.60 to 0.82, p = 0.07). Calibration and net reclassification plots of HMGB1 identified some high-risk patients, whereas the ISTH DIC scores and histone H3 did not. The category-free net reclassification improvement of HMGB1 was 0.45 (95% CI: 0.01 to 0.90, p = 0.04) and that of histone H3 was 0.37 (95% CI: − 0.05 to 0.78, p = 0.08). Conclusions Serum HMGB1 levels have a prognostic value for mortality in patients with DIC. This finding may help physicians develop treatment strategies.

show abstract

Section: Introductionmentioning

confidence: 99%

Prognostic value of plasma high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…immune response (28), and it is a major cause of death in ICUs (29). We found that NC supplementation significantly decreased serum concentrations of IL-17 and IL-22 in septic patients after 10 days of intervention.…”

Section: Discussionmentioning

confidence: 77%

“…As far as we are aware, this is the first study to evaluate NC’s effect on immune response in patients with sepsis. Sepsis, which is defined as the excessive activity of the immune system in dealing with pathogenic factors, leads to systemic inflammatory response, coagulation disorders, endothelial function, and immune response ( 28 ), and it is a major cause of death in ICUs ( 29 ). We found that NC supplementation significantly decreased serum concentrations of IL-17 and IL-22 in septic patients after 10 days of intervention.…”

Section: Discussionmentioning

confidence: 99%

“…The number of organs engaged in MODS is positively correlated to the mortality of sepsis ( 35 ). Scores such as SOFA and MODS are used to properly identify septic patients at higher risk of mortality ( 29 ). In the present study, although NC supplementation did not affect the respiratory rate, PaO2/FiO2, and blood pressure, it significantly decreased the SOFA and MODS scores after 10 days.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluating the effects of curcumin nanomicelles on clinical outcome and cellular immune responses in critically ill sepsis patients: A randomized, double-blind, and placebo-controlled trial

et al. 2022

View full text Add to dashboard Cite

IntroductionIn sepsis, the immune system is overreacting to infection, leading to organ dysfunction and death. The purpose of this study was to investigate the impacts of curcumin nanomicelles on clinical outcomes and cellular immune responses in critically ill sepsis patients.MethodFor 10 days, 40 patients in the intensive care units (ICU) were randomized between the nano curcumin (NC) and placebo groups in a randomized study. We evaluated serum levels of biochemical factors, inflammatory biomarkers, the mRNA expression levels of FOXP3, NLRP-3, IFN-γ, and NF-κp genes in the PBMCs, and clinical outcomes before the beginning of the supplementation and on days 5 and 10.ResultsNLR family pyrin domain containing 3 (NLRP3), interferon gamma (IFN-γ), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) mRNA expression levels significantly P = 0.014, P = 0.014, and P = 0.019, respectively) decreased, but forkhead box P3 (FOXP3) mRNA expression levels increased significantly (P = 0.008) in the NC group compared to the placebo group after 10 days. NC supplementation decreased serum levels of IL-22, IL-17, and high mobility group box 1 (HMGB1) (P < 0.05). Nevertheless, biochemical factors and nutritional status did not differ significantly (P > 0.05). NC supplementation resulted in decreased sequential organ failure assessment and multiple organ dysfunction syndromes scores, while it did not have significant impacts on length of stay in the ICU, systolic blood pressure, diastolic blood pressure, a saturation of oxygen (%), and respiratory rate (breaths/min) PaO2/FiO2 (p > 0.05).ConclusionFor critically ill patients with sepsis, NC supplementation may be an effective therapeutic strategy. More randomized clinical trials involving longer follow-up periods and different doses are needed to achieve the best results.

show abstract

“…Biomarkers such as High Mobility Group Box1 (HMGB-1) and TGF-beta 1 have emerged as promising candidates for further investigation in sepsis pathogenesis. HMGB-1’s role as a potent pro-inflammatory cytokine and its association with poor clinical outcomes make it an important target for further study [ 38 , 39 , 40 ]. TGF beta 1′s complex dual role in sepsis, exhibiting both anti-inflammatory and pro-fibrotic effects, also warrants investigation to understand its contribution to disease progression and potential therapeutic implications [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis

et al. 2023

View full text Add to dashboard Cite

(1) Background: Sepsis is a severe systemic inflammatory condition characterized by rapid clinical deterioration and organ dysfunction. The cholinergic system has been implicated in modulating the inflammatory response. Acetylcholinesterase (AChE), an enzyme primarily responsible for the hydrolysis of acetylcholine, has been proposed as a potential early indicator of sepsis onset. However, the exact role of non-neuronal AChE activity in sepsis and its correlation with disease severity and patient outcomes remain unclear. This study aimed to investigate the involvement of AChE activity in sepsis and evaluate its association with disease severity and clinical outcomes. (2) Methods: A prospective study included 43 septic patients. AChE activity was measured at sepsis detection, as well as 7 and 28 days later. Inflammatory biomarkers, disease severity scores, and patient outcomes were evaluated. (3) Results: AChE activity remained stable for 7 days and decreased at 28 days. However, there was no correlation between initial AChE activity and inflammatory biomarkers, disease severity scores, ICU stay, or hospital stay. (4) Conclusions: Non-neuronal AChE activity may not reliably indicate early sepsis or predict disease severity.

show abstract

Correlation of blood high mobility group box-1 protein with mortality of patients with sepsis: A meta-analysis

Cited by 8 publications

References 25 publications

Prognostic value of plasma high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study

Prognostic value of plasma high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study

Evaluating the effects of curcumin nanomicelles on clinical outcome and cellular immune responses in critically ill sepsis patients: A randomized, double-blind, and placebo-controlled trial

Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis

Contact Info

Product

Resources

About