Correlation of blood gas status with the mortality of neonates admitted in ICU

Yusuf, Mir Mohammad; Chowdhury, Mak Azad

doi:10.3329/nimcj.v9i1.35924

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…In study by Yusuf et al stated that Metabolic acidosis with base excess <5mmol/l is frequently seen in non-survivors and in critically ill patients it serves as a powerful marker for poor prognosis. 9 In the present study it was also found that patient who presented with lethargy had increase level of base excess with a p value of 0.…”

Section: Discussionsupporting

confidence: 70%

Base excess as a predictor of neonatal mortality in neonatal sepsis

K. P.,

M.,

et al. 2023

Int J Contemp Pediatr

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Background: Neonatal sepsis is responsible for approximately 15% of all neonatal deaths in the world. Despite of availability in advanced medical healthcare facilities for mother and neonates, incidence of mortality secondary to sepsis especially in developing countries like India is more common. Metabolic acidosis is the most common form of acid base imbalance in neonatal sepsis which can be analyzed with increased levels of base excess. Hence early diagnosis of neonatal sepsis can be done by determining base excess. Methods: This is a prospective observational study conducted in NICU at Cheluvamba Hospital, Mysore. 73 term neonates with suspected sepsis were enrolled in the study who were on regular follow-up and treatment till death/discharged from NICU. Base excess value is obtained from the arterial blood gas analysis from each subject and it was compared with survivor and non-survivor group along with other study parameter Results: Out of 73 subjects, incidence of non survivors group with severe increase in base excess is 75%. To predict the mortality, we compared it with standard base excess which showed the prediction of more than 60%, with significant AOC (0.827) of very near to one in ROC curve, with statistically significant (p<0.001) sensitivity of 92.59%, specificity of 63.04%, positive predictive value of 59.5%, negative predictive value of 93.5%. Conclusions: In present study we have proved that base excess is an important parameter for the early diagnosis and for early intervention in neonatal sepsis.

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Section: Discussionsupporting

confidence: 70%

Base excess as a predictor of neonatal mortality in neonatal sepsis

K. P.,

M.,

et al. 2023

Int J Contemp Pediatr

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“…The study by M. Mohammad Yusuf showed that: the mortality group had a lower blood pH (7.3±0. 19) than the alive group (7.36±0.1); and the BE of the mortality group was lower (-10.74±15.89 mmol/L) than the live group (-4.3±6.88 mmol/L) [14].…”

Section: Discussionmentioning

confidence: 78%

Clinical characteristics and laboratory test in full-term neonates with sepsis in Vietnam National Children’s Hospital (Northern Vietnam)

Nguyễn

Nguyen

Dang

et al. 2023

Russian Journal of Infection and Immunity

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Background: Sepsis is a life-threatening condition responding to an infectious agent causes damage to organs. Sepsis causes serious consequences in neonates due to high rates of mortality and sequelae and disability. Vietnam is a country in Southeast Asia, where the rate of infectious diseases is high in the world with high rates of infection, disability and mortality, as well as a middle-income country with a stratification health care system. Aim: Evaluate the clinical and laboratory characteristics of patients at the Vietnam National Childrens Hospital. Material and methods: A descriptive study was conducted on 85 full-term infants admitted to Vietnam National Children's Hospital in the period from 12/2019 to 4/2021. Results: Common clinical symptoms in neonates with sepsis included poor feeding (89.4 %), respiratory failure (69.4 %), fever (51.8 %), tachycardia (52.8 %), shock (25 %). Anemic patients account for a high rate (72.9 %). Patients with increased white blood count accounted for 41.2 %, newborns with low white blood count accounted for 15.4 %. There were 49.6 % patients with low thrombocytopenia. Most patients had elevated CRP (88.3%). The mean value of nCD64 was 10167.1 6136.9 molecules bound/cell, mHLA-DR was 9898.4 14173.9 molecules bound/cell, Sepsis Index was 274.6 287.5. Conclusions: We recorded differences in clinical characteristics and Laboratory tests in full-term Neonates with Sepsis in National Children's Hospital. Of which, nCD64, mHLA-DR and Sepsis Index should be further investigated and referred as a prospective routine biomarker in diagnosis of neonatal sepsis.

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Correlation of blood gas status with the mortality of neonates admitted in ICU

Abstract: Background : Blood gas abnormalities are frequently encountered in sick neonates admitted in ICU. They contribute significantly to mortality. Therefore, blood gas status is a helpful indicator of the condition of sick neonate.

Cited by 2 publications

References 11 publications

Base excess as a predictor of neonatal mortality in neonatal sepsis

Base excess as a predictor of neonatal mortality in neonatal sepsis

Clinical characteristics and laboratory test in full-term neonates with sepsis in Vietnam National Children’s Hospital (Northern Vietnam)

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