Correlation of Autophagy-Related Genes in High Risk and Low Risk Signatures Based on Prognostic Index Model SKCM Patient

Abstract

Autophagy plays a dual role in tumor development and autophagy-related genes (ARGs) involved in the development of cancer. However, the correlation between these high and low risk ARGs is still unclear. To systematically study the relationship between ARGs and melanoma patients, the expression profiles of ARGs were integratedly analyzed based on the TCGA and GTEx dataset. The results suggested 8-ARGs marker can predict the prognosis of skin cutaneous melanoma (SKCM), 5-ARGs (CFLAR, DAPK2, ITGA6, DNAJB9 and RGS19) were low risk index, 3-ARGs (EIF2AK2, EGFR and PTK6) were high risk index. Further validation showed CFLAR, DNAJB9 and PTK6 were significant related to SKCM. In tumor immunization, CFLAR and DNAJB9 have stronger correlation with tumor immune cells, and there is a significant positive correlation among the low risk genes. However, there is no significant correlation between the high and low risk factors. In addition, our results also showed that CFLAR and PTK6 were significantly negatively correlated with tumor purity; PTK6 was significantly positively correlated with patient's age, CFLAR was significantly negatively correlated with patient's age; CFLAR and DNAJB9 were significantly positively correlated in purity and age. It provides a new prognostic indicator for patients and a new idea for the mechanism of autophagy in melanoma.