Correlation of atherosclerosis between different topographic sites is highly dependent on the type of hyperlipidemia

Abstract

There is a surprising paucity of studies that provide quantitative correlative data on the extent of atherosclerosis between different topographic sites. The impact of cardiovascular risk factors is dependent on the vascular bed, which underlies site-selective effects on progression of atherosclerosis. Therefore, the intraindividual correlation of atherosclerosis between different topographic sites may be dependent on the specific cardiovascular risk profile. The focused objective of the current study is to evaluate whether the correlation of the extent of atherosclerosis between different topographic sites is dependent on the type of hyperlipidemia. Atherosclerosis was quantified at four different topographic locations in the aorta of rabbits with type II or type III hyperlipidemia. Correlation coefficients and semi-partial correlation coefficients adjusted for plasma lipoproteins and sex were determined to compare the degree of atherosclerosis at different topographic sites. Semi-partial correlations adjusted for total plasma cholesterol, plasma triglycerides, and sex of the intima/media ratio between different topographic sites were highly dependent on the type of hyperlipidemia. E.g., the semi-partial correlation coefficient between the intima/media ratio at the level of the ascending aorta and at the level of the descending thoracic aorta was 0.87 (p < 0.0001) in the model of type II hyperlipidemia and was only 0.10 (p = NS) in the model of type III hyperlipidemia. This divergent pattern was also observed for other intersite correlations. Semi-partial Pearson correlation coefficients were very similar to unadjusted Pearson correlation coefficients. Correlation of atherosclerosis between different topographic sites may vary importantly in relation to the type of hyperlipidemia.

Effect of Dietary Cholesterol and Cholesterol Oxides on Blood Cholesterol, Lipids, and the Development of Atherosclerosis in Rabbits

“…Moreover, LDL, VLDL and IDL contain high amounts of cholesterol. Van Craeyveld et al [17] also reported that the relative atherogenicity of VLDL and LDL is dependent on the topographic site, and correlation of the extent of atherosclerosis between different sites is dependent on the type of hyperlipidemia [18]. It may be due to that oxidative stress is different in atherosclerosis-predisposed regions, and atherosclerosis is an inflammatory disease in which various cytokines play a significant role in the progression of vascular lesions [19].…”

Parametric Determination of Hypoxic Ischemia in Evolution of Atherogenesis

“…The interaction of variably participating agonists contrast with the intimal emergence of incremental hypoxia/ischemia in terms of increasing matrix proteoglycan deposition and cellular proliferation of smooth muscle cells in particular. Atherosclerosis affecting different topographic sites correlate with the type of hyperlipidemia (Van Craeyveld et al, 2011). The platelet/coagulation systems are incremental sequence events as trophic influence in staged convergence of multiple agonists in intimal injury.…”

Increased Remnant Lipoproteins in Apo E Deficient Mice Induce Coronary Atherosclerosis following Transverse Aortic Constriction and Aggravate the Development of Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

“…In contrast, type IIa hyperlipidemia in patients with familial hypercholesterolemia characterized by increased levels of low-density lipoprotein (LDL) cholesterol specifically induces atherosclerotic plaque deposition in the coronary arteries and proximal aorta and does not lead to atherosclerosis in other vascular beds when unescorted by additional cardiovascular risk factors [ 13 ]. The relative atherogenicity of VLDL and LDL has been demonstrated to differ substantially in different parts of the rabbit aorta in a direct comparison of two rabbit models with matched total cholesterol levels but distinct amounts of VLDL cholesterol and LDL cholesterol [ 14 , 15 ].…”