Correlation of asprosin and Nrg-4 with type 2 diabetes Mellitus Complicated with Coronary Heart Disease and the Diagnostic Value

Abstract

Purpose Asprosin is a newly discovered adipose factor secreted by white fat, which is involved in glucose metabolism and inflammation. Neuregulin-4 (Nrg-4) is a new adipose factor released from brown adipose tissue and is considered to play an important role in metabolism. This study aims to explore the association between serum Asprosin, Nrg-4 level and coronary heart disease(CHD) in patients with type 2 diabetes mellitus(T2DM) and the diagnostic value. Patients and methods 157 patients with T2DM were enrolled from Affiliated Hospital of Chengde Medical University between December 2020 to July 2021. These patients were divided into T2DM without CHD group (T2DM-0, n = 80) and T2DM with CHD (T2DM-CHD, n = 77). Serum Asprosin and Nrg-4 expression was detected by enzyme-linked immunosorbent assay, and the correlations between Asprosin or Nrg-4 and clinical and biochemical indicators were analyzed. A receiver operating characteristics curve analysis and area under the curve (AUC) were used to evaluate diagnostic accuracy. Results Serum Asprosin level of the T2DM-CHD group were significantly higher and Nrg-4 level significantly lower than those of the T2DM-0 group.Spearman correlation analysis showed that serum Asprosin levels were significantly positively correlated with diabetes course,history of hypertension, fasting plasma glucose(FPG), glycosylated hemoglobin A1c(HbA1C), triglycerides(TG),triglyceride glucose index(TyG index) and urea, and negatively correlated with ALT (all p < 0.05). Nrg-4 was negatively correlated with history of hypertension, body mass index(BMI), FPG, HbA1C, TG, and TyG indexes (all p < 0.05), and positively correlated with high-density lipoprotein cholesterol(HDL-C)(p < 0.05).Logistic regression analysis showed that after adjusting potential confounders, Asprosin was a risk factor for diabetes mellitus, Nrg-4 was a protective factor.The AUC of Asprosin for diagnosing T2DM-CHD was 0.671 (95% confidence interval [CI] 0.584–0.759), and the AUC of the Nrg4 index for diagnosing T2DM-CHD was 0.772 (95% CI 0.700-0.844). The AUC of Asprosin and Nrg-4 for the combined diagnosis of T2DM-CHD was 0.796 (95% CI 0.726–0.864). Conclusion Asprosin and Nrg-4 may be novel diagnostic biomarkers for T2DM with CHD, as they effectively improved the diagnostic accuracy for T2DM-CHD.

Implications of the Serum Concentrations of Neuregulin-4 (Nrg4) in Patients with Coronary Artery Disease: A Case-Control Study

“… 22 Still, it was lower than the cutoff reported to predict coronary heart disease in patients with type 2 diabetes mellitus (11.175 ng/mL). 47 The Nrg4 level cutoff for diagnosing NAFLD in children and adolescents with obesity was 3.39 ng/mL, 36 approximately near our cutoff. The reported cutoffs of Nrg4 levels are somewhat different, but one finding is consistent in all studies: the decreased levels of Nrg4 in pathologic conditions.…”

Serum Asprosin Correlates with Indirect Insulin Resistance Indices

“…A study by Zhong et al presented a correlation between asprosin and TyG with r = 0.327; however, the research was conducted with diabetic patients [ 38 ]. Therefore, it seems that the correlation between TyG and asprosin is present in both non-diabetic and diabetic patients.…”

Low to High Intensity Exercise dalam Menurunkan Kadar Gula Darah pada Pasien DM Tipe 2

“…Walaupun demikian, kepatuhan untuk melakukan exercise masih rendah, serta banyaknya variasi exercise yang diungkap dari banyak penelitian. Exercise bisa berupa latihan dengan intensitas rendah (low Intensity Exercise), sedang (moderate intensity exercise), maupun tinggi (high intensity exercise) (Thukral et al, 2023;Van Ryckeghem et al, 2022;Zhong et al, 2023).…”