Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and comparison in chronic hepatitis B, liver cirrhosis and liver cancer

Ni, Lina; Li, Chuanbao; Li, Yingbo

doi:10.3892/ol.2020.11257

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…During alanine aminotransferase (ALT) flare-up in HBV carriers, G-to-A hypermutation of HBV increased [ 40 ]. Moreover, A3G mRNA in liver tissues is moderately associated with the ALT content [ 41 ]. These controversial findings surrounding A3G levels in chronic HBV infection need further investigation with a large number of samples.…”

Section: A3 Expressionmentioning

confidence: 99%

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Roles of APOBEC3 in hepatitis B virus (HBV) infection and hepatocarcinogenesis

et al. 2021

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APOBEC3 (A3) cytidine deaminases inhibit hepatitis B virus (HBV) infection and play vital roles in maintaining a variety of biochemical processes, including the regulation of protein expression and innate immunity. Emerging evidence indicates that the deaminated deoxycytidine biochemical activity of A3 proteins in single-stranded DNA makes them a double-edged sword. These enzymes can cause cellular genetic mutations at replication forks or within transcription bubbles, depending on the physiological state of the cell and the phase of the cell cycle. Under pathological conditions, aberrant expression of A3 genes with improper deaminase activity regulation may threaten genomic stability and eventually lead to cancer development. This review attempted to summarize the antiviral activities and underlying mechanisms of A3 editing enzymes in HBV infections. Moreover, the correlations between A3 genes and hepatocarcinogenesis were also elucidated.

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Section: A3 Expressionmentioning

confidence: 99%

“…Multiple approaches confirmed that the content of A3G in liver tissues was the highest in CHB patients, slightly lower in patients with liver cirrhosis and the lowest in liver cancer [ 41 ]. No significant difference in liver A3G products was found between CHB patients and HCC patients in another report [ 38 ].…”

Section: A3 Expressionmentioning

confidence: 99%

Roles of APOBEC3 in hepatitis B virus (HBV) infection and hepatocarcinogenesis

et al. 2021

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“…Comparison of general information between the two groups (n (%), x ± s). AST), total bilirubin (TBIL), and total bile acid (TBA)[10][11][12].…”

mentioning

confidence: 99%

Effect of Entecavir Combined with Adefovir Dipivoxil on Clinical Efficacy and TNF-α and IL-6 Levels in Patients with Hepatitis B Cirrhosis

Cui

Zhao

et al. 2021

Journal of Oncology

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Objective. The purpose of the study was to investigate the effect of entecavir combined with adefovir dipivoxil on clinical efficacy and TNF-α and IL-6 levels in patients with hepatitis B cirrhosis. Methods. A total of 100 patients with hepatitis B cirrhosis admitted to our hospital between January 2018 and June 2019 were randomly selected and divided into the control group (n = 50) and experimental group (n = 50) according to the order of admission. Among them, the control group patients were treated with entecavir, while the patients in the experimental group received entecavir combined with adefovir dipivoxil. After that, the effective rate of treatment, the incidence of adverse reactions, liver function indexes, liver fibrosis condition, and TNF-α and IL-6 expression levels were all compared between the two groups. Results. The effective rate of treatment in the experimental group was significantly higher than that in the control group, with statistical significance ( p < 0.001 ); the incidence of adverse reactions of the patients in the experimental group was significantly lower than that in the control group, with statistical significance ( p < 0.001 ); the liver function indexes in the experimental group were significantly better than those in the control group, with statistical significance ( p < 0.001 ); the number of patients with liver fibrosis in the experimental group was significantly less than that in the control group, with statistical significance ( p < 0.001 ); the TNF-α and IL-6 expression levels in the experimental group were significantly lower than those in the control group, with statistical significance ( p < 0.001 ). Conclusion. Entecavir combined with adefovir dipivoxil in the treatment of hepatitis B cirrhosis can effectively improve the therapeutic effect and reduce the serum inflammatory factor levels, with high safety, which is worthy of application and popularization.

show abstract

Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and comparison in chronic hepatitis B, liver cirrhosis and liver cancer

Cited by 2 publications

References 21 publications

Roles of APOBEC3 in hepatitis B virus (HBV) infection and hepatocarcinogenesis

Roles of APOBEC3 in hepatitis B virus (HBV) infection and hepatocarcinogenesis

Effect of Entecavir Combined with Adefovir Dipivoxil on Clinical Efficacy and TNF-α and IL-6 Levels in Patients with Hepatitis B Cirrhosis

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