Correlation of antimüllerian hormone and baseline follicle-stimulating hormone levels

Singer, T.; Barad, David H.; Weghofer, Andrea; Gleicher, Norbert

doi:10.1016/j.fertnstert.2008.03.034

Cited by 79 publications

(66 citation statements)

References 35 publications

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“…Many authors suggested that antral follicle count, an important marker of ovarian reserve, decreases with advancing age, and correspondingly, serum AMH levels also decrease with advancing age (8,14). In our study, we found a statistically significant positive correlation between AMH levels and antral follicle count.…”

Section: Discussionsupporting

confidence: 72%

Determination of Ovarian Reserve with Anti-Mullerian Hormone in Patients with Polycystic Ovary Syndrome and Premenopausal Women

İnan¹,

Yücel²,

Isbilen³

et al. 2014

JAREM

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Objective: We aimed to evaluate the capacity of measuring serum anti-mullerian hormone (AMH) levels in determining ovarian reserve in patients with polycystic ovary syndrome (PCOS) with increased ovarian reserve and in premenopausal women with decreased ovarian reserve.Methods: Seventy-five patients who presented to our clinic between May-September 2011 were included. The patients comprised 25 (20-35 years) with PCOS, 25 (20-35 years) with normo-ovulatory cycle, and 25 (40-45 years) in the premenopausal period. Blood specimen was taken from patients during the early follicular period (on the third day of spontaneous menstrual cycles) and FSH, LH, estradiol (E2), and AMH levels were analyzed. In addition, body mass indexes (BMI) of the patients were calculated by measuring their heights and weights.Results: We determined statistically significant differences between groups regarding AMH values (p<0.001). We determined the mean AMH value of the PCOS group to be 58.45±33.68 pmol/L, 19.92±21.35 pmol/L for the control group, and 2.47±5.31 pmol/L for the premenopausal group. We found a statistically significant negative relationship between AMH and BMI levels in all cases without discrimination (r:-0,277; p=0.016), and we found a statistically significant positive relationship between AMH and AFC (antral follicle count) (r: 0.908; p=<0.001).Conclusion: AMH is a highly specific biomarker in determining ovarian reserve. High levels of AMH values in patients with PCOS and low levels in premenopausal women demonstrate that AMH is a safe biomarker in determining ovarian reserve. (JAREM 2014; 2: 62-8) Key Words: Polycystic ovary syndrome, follicle-stimulating hormone, anti-mullerian hormone ÖZET Amaç: Over rezervinin arttığını bildiğimiz polikistik over sendromlu (PCOS) hastalarla, azaldığını bildiğimiz premenopoz dönemdeki kadınlarda serum anti-mullerian hormon (AMH) düzeylerinin over rezervini belirlemedeki kapasitesini değerlendirmek çalışmamızın temel amacıdır.Yöntemler: Çalışmamıza Mayıs-Eylül 2011 tarihleri arasında kliniğimize başvuran 75 hasta dahil edildi. Bunlardan 25 hasta (yaşları 20-35 arasında) PCOS hastası; 25 hasta (yaşları 20-35 arasında) normal ovulatuar siklusları olan hastalar; 25'i ise yaşları 40-45 yaş arasında olan premenopoz dönemdeki hastalardan oluşturuldu. Tüm hastalardan erken foliküler dönemde kan numunesi alındı (normal menstruel siklusun 3. günü) ve follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-mullerian hormone (AMH) değerleri analiz edildi. Ayrıca hastaların vücut kitle indeksleri (VKİ) boy ve kilo değerleriyle hesaplandı.Bulgular: Gruplar arasında AMH değerleri açısından istatistiksel anlamlı farklılıklar saptadık (p<0,001). PCOS grubunun AMH değeri ortalamasını 58,45±33,68 pmol/L; kontrol grubun AMH değeri ortalamasını 19,92±21,35 pmol/L; premenopoz grubun AMH değeri ortalamasını 2,47±5,31 pmol/L olarak saptadık. Herhangi bir ayrım yapmadan tüm vakaları dahil ettiğimiz analizde AMH ve VKİ düzeyleri arasında negatif yönde istatistiksel olarak anlamlı ilişki b...

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Section: Discussionsupporting

confidence: 72%

Determination of Ovarian Reserve with Anti-Mullerian Hormone in Patients with Polycystic Ovary Syndrome and Premenopausal Women

İnan¹,

Yücel²,

Isbilen³

et al. 2014

JAREM

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“…In the past, the use of early follicular FSH serum levels was considered the gold standard for assessing ovarian reserve; however, multiple other metrics have since emerged with robust studies supporting their use. Using baseline FSH levels, linear correlations demonstrate that rising FSH values correspond with decreasing AMH values; however, predictive superiority for actual IVF outcomes has yet to be coordinated [21]. When a single marker is selected, AMH appears to outperform other markers of poor ovarian reserve in predicting oocytes retrieved and the number of canceled cycles [20]; however, findings throughout the literature are mixed [22].…”

Section: Discussionmentioning

confidence: 99%

Use of anti-mullerian hormone for testing ovarian reserve: a survey of 796 infertility clinics worldwide

Tobler

Shoham

Christianson

et al. 2015

J Assist Reprod Genet

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Purpose The aim of this study is to assess how anti-mullerian hormone (AMH) is used worldwide to test ovarian reserve and guide in vitro fertilization (IVF) cycle management. Methods An internet-based survey was sent electronically to registered IVF providers within the IVF-Worldwide.com network. This survey consisted of nine questions which assessed the clinics' use of AMH. The questionnaire was completed online through the IVF-Worldwide.com website, and quality assurance tools were used to verify that only one survey was completed per clinical IVF center. Results are reported as the proportion of IVF cycles represented by a particular answer choice. Results Survey responses were completed from 796 globally distributed IVF clinics, representing 593,200 IVF cycles worldwide. Sixty percent of the respondent-IVF cycles reported to use AMH as a first line test, and 54 % reported it as the best test for evaluating ovarian reserve. Eighty-nine percent reported that AMH results were extremely relevant or relevant to clinical practice. However in contrast, for predicting live birth rate, 81 % reported age as the best predictor. Conclusions AMH is currently considered a first line test for evaluating ovarian reserve and is considered relevant to clinical practice by the majority of IVF providers.

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“…Serum levels of AMH correlate strongly with the number of antral follicles, suggesting that AMH levels reflect the size of primordial follicle pool. AMH inhibits excessive follicular recruitment by FSH and therefore has a critical role in folliculogenesis [17,18] It was previously reported that AMH serum levels do not significantly change throughout the menstrual cycle [19][20][21]. However, recent reports revealed statistically significant cyclical fluctuations in AMH levels with a rapid decrease in AMH levels in the early luteal phase [22,23].…”

Section: Discussionmentioning

confidence: 99%

Anti-mullerian hormone and cumulative pregnancy outcome in in-vitro fertilization

Kini

Morrell

et al. 2010

J Assist Reprod Genet

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Purpose To evaluate the role of Anti-mullerian hormone (AMH) in predicting cumulative pregnancy outcome during in-vitro fertilization (IVF) treatment. Methods Serum AMH levels on day 6 of ovarian stimulation were taken from 180 women undergoing IVF with or without intracytoplasmic sperm injection (ICSI). The main outcome measures were ongoing pregnancy in the fresh cycle, cumulative ongoing pregnancy and ovarian response.Results There was a trend of higher median AMH levels in subjects achieving ongoing pregnancy in the fresh IVF cycle. The median AMH levels were significantly higher in subjects attaining ongoing pregnancy cumulatively and in subjects showing ovarian hyper-response in the stimulated cycle. Areas under the ROC curves were 0.606 and 0.792 for the prediction of cumulative ongoing pregnancy and ovarian hyper-response respectively. Conclusions Serum AMH concentration on day 6 of stimulation was significantly higher in subjects who achieved cumulative ongoing pregnancy in IVF compared to those who did not. Serum AMH is a reasonably good predictor of ovarian hyper-response.

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Correlation of antimüllerian hormone and baseline follicle-stimulating hormone levels

Cited by 79 publications

References 35 publications

Determination of Ovarian Reserve with Anti-Mullerian Hormone in Patients with Polycystic Ovary Syndrome and Premenopausal Women

Determination of Ovarian Reserve with Anti-Mullerian Hormone in Patients with Polycystic Ovary Syndrome and Premenopausal Women

Use of anti-mullerian hormone for testing ovarian reserve: a survey of 796 infertility clinics worldwide

Anti-mullerian hormone and cumulative pregnancy outcome in in-vitro fertilization

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