Correlation of anal cytology with follow-up histology and Human Papillomavirus genotyping: A 10-year experience from an academic medical center

Hopp, Amanda; Pant, Mamta; Sniedze, Sally; Parsons, Lauren; Hunt, Bryan; Giorgadze, Tamara

doi:10.1016/j.anndiagpath.2020.151670

Cited by 4 publications

(16 citation statements)

References 19 publications

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“…Another highlight of the current study was that it reported that the most frequent cause of unsatisfactory samples in the two methods was hypocellularity. More recent studies have confirmed the occurrence of hypocellularity in LBC 23,24,17 . Phanuphak et al 8 reassessed the two methods' performance and reported a minimal rate of unsatisfactory samples, namely 1.7% in LBC and zero in CC.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Conventional cytologic diagnosis of human papillomavirus‐induced anal intraepithelial neoplasia: The experience of a referral center in Rio de Janeiro, Brazil

Barcellos

Coutinho

Cytryn

et al. 2022

Diagnostic Cytopathology

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Background Screening of anal cancer is rarely available or performed in Brazil. This study analyzes the diagnostic performance of conventional cytology (CC) in the prevention of anal cancer in a coloproctology and gynecology outpatient clinics in a public hospital in Rio de Janeiro, Brazil. Methods From 2005 to 2017, 1066 conventional cytological samples were collected. We analyze the causes of unsatisfactory samples (11.3%) and compare the cytological diagnoses of 83 samples from persons living with HIV and persons not living with HIV and in specific situations, using as the gold standard high‐resolution anoscopy or histopathology in cases biopsied within 6 months after cytology. Results The sensitivity of cytology with diagnosis of ASC‐US for detection of anal intraepithelial neoplasia of any grade was 85%, specificity was 41%, positive and negative predictive values were 64% and 75%, respectively, and positive and negative likelihood ratios were 1.46 and 0.35, respectively. Conclusion Conventional cytology available in resource‐limited settings is a simple, noninvasive, low‐cost method that proved feasible for outpatient screening of precursor lesions of the anal canal.

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Section: Discussionmentioning

confidence: 96%

“…23,24,17 Phanuphak Diagnoses from anal cytology, high-resolution anoscopy (HRA), and histopathology (when obtained) for calculation of diagnostic performance (n = 83) (2005-2017).…”

mentioning

confidence: 99%

Conventional cytologic diagnosis of human papillomavirus‐induced anal intraepithelial neoplasia: The experience of a referral center in Rio de Janeiro, Brazil

Barcellos

Coutinho

Cytryn

et al. 2022

Diagnostic Cytopathology

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“…It is generally accepted that the pathophysiology of anal SqCC is similar to that of its cervical counterpart, progressing from dysplastic lesions to carcinoma, particularly those lesions within the transformation zone between squamous and glandular epithelium [7][8][9][10]. However, unlike cervical cancer, guidelines for anal cancer screening, including whom to screen, are not yet well defined and/or standardized [3-5, 11, 12].…”

Section: Anal Cancer Screeningmentioning

confidence: 99%

“…Some studies have shown, though, that a consensus opinion, particularly in challenging cases, can be beneficial to help combat the interobserver variability seen in anal cytology. For example, a recent single institutional study [7] looked at discrepancies between anal cytology and biopsy specimens. As a component of the study, all discrepant cases were reviewed and consensus opinion documented.…”

Section: Anal Cytology Interpretation and Performancementioning

confidence: 99%

Comprehensive Review of Anal Cytology

2023

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Background: The incidence of anal cancer has increased over at least the past decade, with estimates of a continued increase in the coming years. Women are more commonly affected than men in the general population; separate high-risk populations have also been identified. While the pathophysiology of anal cancer is thought to be similar to its cervical counterpart, well-defined and standardized screening guidelines have not been established as is seen in cervical cancer prevention. Nonetheless, multiple screening modalities have been examined and are components of proposed institutional and societal screening programs. Summary: Anal cytology is one modality that is a mainstay of many suggested screening guidelines. Interpretation and reporting follow current criteria for cervical/vaginal cytology per the Bethesda System, with site-specific alterations and changes in adequacy criteria to better accommodate some of the confounding factors encountered in anal cytology. While there are some limitations, such as a tendency to underestimate the degree of dysplasia and variable interobserver concordance rates, anal cytology, especially liquid-based preparations, overall performs well in detecting anal abnormalities and acts as an adequate screening tool. Importantly, most anal squamous dysplasias and cancers are also associated with human papillomavirus (HPV) infection, raising the possibility of HPV testing or genotyping as a component of screening and/or follow-up. Studies have also shown the efficacy of HPV vaccination in preventing anal lesions. Digital anorectal exam as well as anoscopy, particularly high-resolution anoscopy, are also often components of screening and follow-up. Management guidelines such as those put forth by the American Society for Colposcopy and Cervical Pathology (ASCCP) for cervical cancer are also not established for anal cancer. However, studies such as the Anal Cancer HSIL Outcomes Research (ANCHOR) trial have made significant strides in demonstrating successes in follow-up and treatment of anal lesions, findings that are crucial for establishing prevention and management guidelines going forward.

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“…An estimated 29,000 people were diagnosed with squamous cell carcinoma of anus every year (Clifford, 2021). However prevalence has risen in the United State, with 2019 SEER data showing an increasing rate of 2.2% each year over the last 10 years (Hopp, 2021). Siegel et al, (2012) reported that the prevalence of anal cancer in men who have sex with men or HIV patients was 35 in 100,000 patients while new cases of anal cancer in female is 2.06 in 100,000 females (Salati and Kadi, 2012).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Abnormal Anal Cytology in Women with Abnormal Cervical Cytology

Inthasorn

Wetpithayakom

Laiwejpithaya

et al. 2021

Asian Pac J Cancer Prev

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Objective: The aim of this study was to evaluate the prevalence of abnormal anal cytology in women presenting with abnormal cervical cytology (intraepithelial lesion or cervical cancer) at the largest tertiary university hospital in Thailand. Methods: A cross-sectional prospective study design was used. Anal cytology was performed on 145 women with abnormal cervical cytology between June 2014-Octoble 2014. If abnormal anal cytology was detected, anoscopy was performed with biopsy in any suspicious area of precancerous change. Results: Prevalence of abnormal anal cytology was 5.5% (8 patients). Of 8 patients, six patients presented with low-grade squamous intraepithelial lesion, one patient with high-grade squamous intraepithelial lesion, and one with atypical squamous cell cannot exclude highgrade squamous intraepithelial lesion. Abnormal anoscopic impression was found in 3 cases, as follow: The first case showed faint acetowhite lesion and anoscopic impression was low grade squamous intraepithelial lesion; the second case was reported as human papillomavirus (HPV) change by anoscopic impression; and the third case showed dense acetowhite lesion with multiple punctation and pathologic examination showed anal intraepithelial neoplasm III (AIN3). The last patient underwent wide local excision of AIN3 with split-thickness skin graft reconstruction. Final pathology confirmed AIN3 with free resection margin. Conclusion: Prevalence of abnormal anal cytology was 5.5% in patients with abnormal cervical cytology. The prevalence might be support anal cytology screening in this group of patients.

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Correlation of anal cytology with follow-up histology and Human Papillomavirus genotyping: A 10-year experience from an academic medical center

Cited by 4 publications

References 19 publications

Conventional cytologic diagnosis of human papillomavirus‐induced anal intraepithelial neoplasia: The experience of a referral center in Rio de Janeiro, Brazil

Conventional cytologic diagnosis of human papillomavirus‐induced anal intraepithelial neoplasia: The experience of a referral center in Rio de Janeiro, Brazil

Comprehensive Review of Anal Cytology

Prevalence of Abnormal Anal Cytology in Women with Abnormal Cervical Cytology

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