Correlation of 99Tcm-sestamibi SPECT with coronary angiography in general hospital practice

G, Solot; Hermans, John J.; Merlo, Pablo; Jm, Chaudron; Luwaert, R.; Cheron, P.; Bodart, F; Beauduin, M.

doi:10.1097/00006231-199301000-00006

Cited by 25 publications

(10 citation statements)

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“…Among the studies which recruited more than 100 patients, Van Train and colleagues reported a sensitivity of 90% and specificity of 36% in 124 patients (19% had a previous myocardial infarct) who underwent exercise sestamibi SPECT and coronary angiography 29. Solot and associates reported a sensitivity of 97% and specificity of 71% for exercise sestamibi SPECT in 128 patients 31. Previous studies of exercise tetrofosmin imaging reported a sensitivity ranging between 58% and 95% and a specificity ranging between 54% and 95% for the diagnosis of coronary artery disease 32-34…”

Section: Discussionmentioning

confidence: 99%

Impact of hypertension on the accuracy of exercise stress myocardial perfusion imaging for the diagnosis of coronary artery disease

Elhendy

Domburg

Sozzi

et al. 2001

Heart

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Aim-To compare the accuracy of exercise stress myocardial perfusion single photon emission computed tomography (SPECT) imaging for the diagnosis of coronary artery disease in patients with and without hypertension. Methods-A symptom limited bicycle exercise stress test in conjunction with 99m technetium sestamibi or tetrofosmin SPECT imaging was performed in 332 patients (mean (SD) age, 57 (10) years; 257 men, 75 women) without previous myocardial infarction who underwent coronary angiography. Of these, 137 (41%) had hypertension. Rest SPECT images were acquired 24 hours after the stress test. An abnormal scan was defined as one with reversible or fixed perfusion defects. Results-In hypertensive patients, myocardial perfusion abnormalities were detected in 79 of 102 patients with significant coronary artery disease and in nine of 35 patients without. In normotensive patients, myocardial perfusion abnormalities were detected in 104 of 138 patients with significant coronary artery disease and in 16 of 57 patients without. There were no diVerences between normotensive and hypertensive patients in sensitivity (77% (95% confidence interval (CI) 69% to 86%) v 75% (95% CI 68% to 83%)), specificity (74% (95% CI 60% to 89%) v 72% (95% CI 60% to 84%)), and accuracy (77% (95% CI 70% to 84%) v 74% (95% CI 68% to 80%)) of exercise SPECT for diagnosing coronary artery disease. The accuracy of SPECT was greater than electrocardiography, both in hypertensive patients (p = 0.005) and in normotensive patients (p = 0.0001). For the detection of coronary artery disease in individual vessels, sensitivity was 58% (95% CI 51% to 65%) v 57% (95% CI 51% to 64%), specificity was 86% (95% CI 82% to 90%) v 85% (95% CI 81% to 89%), and accuracy was 74% (95% CI 70% to 78%) v 74% (95% CI 70% to 78%) in patients with and without hypertension (NS). Conclusions-In the usual clinical setting, the value of exercise myocardial perfusion scintigraphy for diagnosing coronary artery disease is not degraded by the presence of hypertension. (Heart 2001;85:655-661)

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Section: Discussionmentioning

confidence: 99%

Impact of hypertension on the accuracy of exercise stress myocardial perfusion imaging for the diagnosis of coronary artery disease

Elhendy

Domburg

Sozzi

et al. 2001

Heart

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“…The forest plot for sensitivity (figure 2) showed heterogeneity (Cochrane Q p<0.1). Six small-sample-size studies were primarily responsible for this heterogeneity 37 39 43 45 47 49. However, there was no significant heterogeneity in the forest plot for negative likelihood ratio (1−Sensitivity/Specificity; figure 3), implying that it is reasonable to combine the included studies to obtain pooled estimates.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic accuracy of myocardial perfusion imaging and stress echocardiography for the diagnosis of left main and triple vessel coronary artery disease: a comparative meta-analysis

Mahajan

Polavaram

Vankayala

et al. 2010

Heart

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Since LM alone or in combination with TVD are categorised as representing potentially life-threatening variants of CAD, a screening test with high sensitivity, low negative likelihood ratio or higher discriminatory capacity would be desirable for risk stratification. In the absence of a direct head-to-head comparison of the diagnostic accuracies of SE and MPI, our findings indicate that SE appears to be the preferred screening modality for high-risk coronary artery disease.

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“…[28][29][30] It is possible that the observed disagreements between these tests could partially be explained by variability in interpretation of the imaging studies. However this is unlikely to fully explain the observed differences.…”

Section: Discussionmentioning

confidence: 99%

Variability of myocardial ischemic responses to mental versus exercise or adenosine stress in patients with coronary artery disease

Hassan

York

Qin

et al. 2008

Journal of Nuclear Cardiology

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Background-Mental stress precipitates myocardial ischemia in a significant percentage of Coronary Artery Disease (CAD) patients. Exercise or adenosine stresses produce different physiologic responses and cause myocardial ischemia via different mechanisms. Little is known about the comparative severity and location of myocardial ischemia provoked by these different stressors. In this study we sought to compare the within-individual ischemic responses to mental versus exercise or adenosine stress in a cohort of CAD patients.

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Correlation of 99Tcm-sestamibi SPECT with coronary angiography in general hospital practice

Cited by 25 publications

References 0 publications

Impact of hypertension on the accuracy of exercise stress myocardial perfusion imaging for the diagnosis of coronary artery disease

Impact of hypertension on the accuracy of exercise stress myocardial perfusion imaging for the diagnosis of coronary artery disease

Diagnostic accuracy of myocardial perfusion imaging and stress echocardiography for the diagnosis of left main and triple vessel coronary artery disease: a comparative meta-analysis

Variability of myocardial ischemic responses to mental versus exercise or adenosine stress in patients with coronary artery disease

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