Correlation of 6‐min walk test with left ventricular function and quality of life in heart failure due to Chagas disease

Chambela, Mayara C.; Mediano, Mauro Felippe Felix; Ferreira, Roberto Rodrigues; Japiassú, André Miguel; Waghabi, Mariana Caldas; Silva, Gilberto M. S. da; Saraiva, Roberto Magalhães

doi:10.1111/tmi.12939

Cited by 16 publications

(18 citation statements)

References 48 publications

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“…In the present study, risk factors for the prognosis of PIH complicated with heart failure were also analyzed. The results showed that blood pressure, 6MWT, LVEF and LVEDD were independent risk factors for the disease, consistent with the views of Chambela et al (27).…”

Section: Discussionsupporting

confidence: 90%

Correlation of miR-21 and BNP with pregnancy-inducedhypertension complicated with heart failureand the diagnostic value

et al. 2019

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Correlation of miR-21 and B-type natriuretic peptide (BNP) with pregnancy-induced hypertension (PIH) complicated with heart failure and the diagnostic value was investigated. Sixty patients with PIH complicated with heart failure admitted to Affiliated Hospital of Chengde Medical University from July 2016 to July 2017 were enrolled as the experimental group, and 35 normal pregnant women as the control group. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) method was used to determine the expression level of plasma miR-21 expression level. An automatic biochemical analyzer was used to determine plasma BNP expression level. Spearman's correlation analysis was used for the correlation analysis of miR-21 and BNP. ROC curve was used for evaluating the diagnostic values of miR-21 and BNP for PIH complicated with heart failure. miR-21 and BNP expression levels were higher in patients with PIH complicated with heart failure than those in the normal individuals, and were increased in line with the heart failure grade (P<0.001). The plasma miR-21 expression was positively correlated with BNP in patients with PIH complicated with heart failure (r=0.685, P<0.001). Both miR-21 and BNP had higher diagnostic values for PIH complicated with heart failure, in the diagnosis, the best cutoff value [odds ratio (OR)] of miR-21 was 1.113, with an area under curve (AUC) of 0.889 and a 95% confidence interval (CI) of 82.05-95.76%; the OR of BNP was 123, with an AUC of 0.747 and a 95% CI of 64.95-84.38%. Blood pressure, six-minute walk test (6MWT), left ventricular ejection fraction (LVEF) and left ventricular end diastolic diameter (LVEDD) were independent risk factors for the occurrence of PIH complicated with heart failure (P<0.05). In conclusion, miR-21 and BNP, highly expressed in patients with PIH complicated with heart failure, are expected to become important biomarkers for diagnosing PIH complicated with heart failure and judging the degree of heart failure in the patients, and worthy of clinical popularization and application.

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Section: Discussionsupporting

confidence: 90%

Correlation of miR-21 and BNP with pregnancy-inducedhypertension complicated with heart failureand the diagnostic value

et al. 2019

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“…The 6MWD has been used as part of several assessment parameters including physical function, exercise capacity, quality of life, and a prognostic marker of readmission or mortality. 32,33) Oxygen uptake, which is regulated by cardiac function and skeletal muscle function, is a standard marker of exercise capacity. 8) In patients with heart failure, 6MWD and oxygen uptake are shown to be correlated, and 6MWD can be used as a prognostic marker of heart disease.…”

Section: Discussionmentioning

confidence: 99%

Physical Function and Cardio-Ankle Vascular Index in Elderly Heart Failure Patients

et al. 2020

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The number of heart failure patients is increasing rapidly in Japan because of its large elderly population. As age increases, arterial stiffness and physical dysfunction progress. This study aimed to evaluate the association between the physical function and arterial stiffness in elderly heart failure patients.This retrospective, observational study includes data from 100 heart failure patients aged !65 years who were admitted to our hospital and underwent cardiac rehabilitation. The Cardio-Ankle Vascular Index (CAVI) was measured as an indicator of arterial stiffness. Body composition was assessed by bioelectrical impedance analysis. To determine the degree of physical function, we assessed handgrip strength, five-meter walk speed (5 MWS), five-repetition sit-to-stand time (5RSST) and six-minute walk distance (6MWD). Sarcopenia was defined using Asian guidelines based on physical function and body composition.Among 100 patients, 47.0% of patients had sarcopenia. After adjustments for age, sex, atrial fibrillation, and ischemic cardiomyopathy, CAVI was significantly higher in with sarcopenia patients than those without sarcopenia. Age, handgrip strength, 5MWS, 5RSST, and 6MWD were associated with CAVI, and 6MWD was as an independent determinant factor of CAVI.6MWD was recognized as an accurate physical function indicator. These findings suggested that physical function and arterial stiffness complement each other. To restore cardiac dysfunction, improving both arterial stiffness and physical function might be useful.

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“…One of the preplanned outcomes (6‐min walk test) was not obtainable from all patients at all time points due to technical reasons. The results obtained for 6‐min walk test at baseline evaluation were previously published …”

Section: Methodsmentioning

confidence: 99%

Impact of pharmaceutical care on the quality of life of patients with heart failure due to chronic Chagas disease: Randomized clinical trial

Chambela

Mediano

Carneiro

et al. 2019

Brit J Clinical Pharma

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Aims: Chronic Chagas disease (ChD) has high morbimortality and loss in quality of life due to heart failure (HF). Pharmaceutical care (PC) optimizes clinical treatment and can improve quality of life in HF. We evaluated if PC improves quality of life of patients with ChD and HF.Methods: Single-blinded, randomized, controlled trial that assigned adult patients with ChD and HF (81 patients; 61 ± 11 years; 48% male) to PC (n = 40) or standard care (n = 41). Quality of life according to SF-36 and Minnesota living with HF questionnaires, incidence of drug-related problems (DRPs), and adherence to medical treatment were determined at baseline and at every 3 months for 1 year. Intentionto-treat analyses were performed by mixed linear model to verify the treatment effect on the changes of these variables throughout the intervention period.Results: Relative changes from baseline to 1 year of follow-up of the domains physical functioning (+16.6 vs -8.5; P < .001), role-physical (+34.0 vs +5.2; P = .01), general health (+19.4 vs -6.1; P < .001), vitality (+11.5 vs. -5.8; P = .003), social functioning (+7.5 vs -13.3; P = .002), and mental health (+9.0 vs -3.7; P = .006) of the SF-36 questionnaire and the Minnesota living with HF questionnaire score (−12.7 vs +4.8; P < .001) were superior in the PC group than in the standard care group. Adherence to medical treatment increased as early as after 3 months of follow-up and DRPs incidence decreased after 6 months of follow-up only in the PC group.Conclusions: Patients with ChD and HF who received PC presented improved quality of life, decrease in DRP frequency, and increase in medication adherence.

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Correlation of 6‐min walk test with left ventricular function and quality of life in heart failure due to Chagas disease

Cited by 16 publications

References 48 publications

Correlation of miR-21 and BNP with pregnancy-inducedhypertension complicated with heart failureand the diagnostic value

Correlation of miR-21 and BNP with pregnancy-inducedhypertension complicated with heart failureand the diagnostic value

Physical Function and Cardio-Ankle Vascular Index in Elderly Heart Failure Patients

Impact of pharmaceutical care on the quality of life of patients with heart failure due to chronic Chagas disease: Randomized clinical trial

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