Correlation of 5‐HTR6 gene polymorphism with vestibular migraine

Wu, Xia; Qiu, Feng; Wang, Zhiwei; Liu, Bing; Qi, Xiaokun

doi:10.1002/jcla.23042

Cited by 9 publications

(2 citation statements)

References 21 publications

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“…The genetic association studies retrieved have reported allelic variants in the HTR6 and PRG genes associated with VM (Lee et al, 2007 ; Wu et al, 2020 ). Replication studies are needed to validate these results.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Prevalence Studies and Familial Aggregation in Vestibular Migraine

2020

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Background: Vestibular migraine (VM) is complex disorder consisting of episodes of migraine and vertigo with an estimated prevalence of 1-3%. As migraine, it is considered that VM has genetic predisposition; however, evidence to support a genetic contribution has not been critically appraised. Objective: The aim of this systematic review is to assess available evidence in scientific publications to determine the role of inheritance in VM. Methods: After performing the quality assessment of the retrieved records, 31 studies were included (24 epidemiological reports and 7 genetic association studies in families or case-control in candidate genes). We gathered data about prevalence of VM in different populations and in families, and also about the genetic findings reported. In addition, other variables were considered to assess the heritability of VM, such as the ancestry, the age of onset or the familial history of vertigo and migraine. Results: The estimated prevalence of VM was different between black (3.13%), white (2.64%) and Asian (1.07%) ethnicities. The reported prevalence of VM in migraine patients is higher in European countries (21%) than in Asian countries (10%). Moreover, the prevalence of the migraine-vertigo association in families is 4-10 times higher than the prevalence reported in the general population (sibling recurrence risk ratio λ s = 4.31-10.42). We also found that the age of onset is lower in patients with simultaneous onset of symptoms and in those who have familial history for migraine and/or vertigo, suggesting anticipation. Although some genetic studies have reported few allelic variants associated to MV, replication studies are needed to validate these results. Conclusions: The available evidence to support heritability in VM is limited. Variability in prevalence depending on ethnicity and geographic location suggests a combined genetic and environmental contribution to VM. However, the familial aggregation observed in VM support genetic and shared familial environmental effects that remarks the necessity of twins and adoptees-based epidemiological studies to estimate its heritability.

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Section: Discussionmentioning

confidence: 99%

Systematic Review of Prevalence Studies and Familial Aggregation in Vestibular Migraine

2020

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“…Another pathophysiological mechanism in VM may be a visuo-vestibular problem, as patients with VM have a longer duration of post-rotatory nystagmus compared to healthy controls or ordinary migraine patients [39]. Plus, a genetic component in the pathogenesis of VM has been identified [28,40].…”

Section: Pathophysiology Of Vmmentioning

confidence: 99%

Vestibular migraine — an underdiagnosed cause of vertigo. Diagnosis and treatment

Nowaczewska

2020

Neurol Neurochir Pol.

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Introduction. Migraine and vertigo are two common conditions. The main disorder connecting both these entities is vestibular migraine (VM). State of the art. VM may affect 1-3% of the general population. It is a disabling disease of recurrent attacks of vestibular symptoms accompanied by migraine features which occur in patients with a current or previous history of migraine. The episodes can last minutes, hours or even days, and may occur without any concurrent headache, which can prompt misdiagnosis. VM often begins several years after a typical migraine, and the delay between onset of headache and vertigo may be long. The diagnosis is based on the patient's clinical history and can be challenging due to the lack of an established confirmatory diagnostic test or biomarkers. The mechanism of vestibular migraine remains unclear and is still under investigation, but it seems to be an interaction between trigeminal and vestibular systems. Due to the lack of specific trials, treatment recommendations are based on migraine guidelines. Several drugs seem to be effective, although there have been few randomised controlled trials in this area. Regardless of the published strict and detailed diagnostic criteria, this condition remains little known, and as a consequence is underdiagnosed and undertreated. Clinical implications. Efforts should be made to educate medical communities and patients about this disease and to encourage neurologists and ENT specialists to cooperate. Every patient with vertigo of unknown origin should be directly asked about a past or present history of migraine, or migraine symptoms experienced during their vertigo episodes. Future directions. There is a growing need for studies regarding the pathophysiology of VM as well as randomised trials to establish clear treatment recommendations and to improve management of this surprisingly common disorder.

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Altered functional connectivity within and between resting-state networks in patients with vestibular migraine

Han

Chen

et al. 2022

Neuroradiology

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Correlation of 5‐HTR6 gene polymorphism with vestibular migraine

Cited by 9 publications

References 21 publications

Systematic Review of Prevalence Studies and Familial Aggregation in Vestibular Migraine

Systematic Review of Prevalence Studies and Familial Aggregation in Vestibular Migraine

Vestibular migraine — an underdiagnosed cause of vertigo. Diagnosis and treatment

Altered functional connectivity within and between resting-state networks in patients with vestibular migraine

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