Abstract:Purpose: 4 0 -[methyl-11 C]-thiothymidine (4DST) has been developed as an in vivo cell proliferation marker based on the DNA incorporation method. We evaluated 4DST uptake on PET in patients with newly diagnosed and recurrent gliomas and correlated the results with proliferative activity.Methods: 4DST PET was investigated in 32 patients, including 21 with newly diagnosed gliomas and 11 with recurrent gliomas. PET imaging was performed at 15 min after 4DST injection. The standardized uptake value (SUV) was dete… Show more
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