Correlation between Wnt signaling and T-cell infiltration in high-grade serous ovarian cancer

Goldsberry, Whitney N.; Phillips, Robert A.; Montgomery, Allison M.; Katre, Ashwini A.; Doo, David W.; Norian, Lyse A.; Randall, Troy D.; Yemelyanova, Anna; Cooper, Sara J.; Arend, Rebecca C.

doi:10.1016/j.ygyno.2019.04.170

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, it was shown in the study by Goldsberry et al [109] that there is an inverse association between the Wnt signaling pathway and TILs. This study examined the effect of neoadjuvant chemotherapy and the relationship between the Wnt signaling pathway and tumor-infiltrating lymphocytes in HGSOC [109]. Additional investigation is required to better understand the Wnt pathway's role in immune regulation.…”

Section: Pd-1/pd-l1 Axis' Impact On T-cd4+ and T-cd8+ Functionmentioning

confidence: 93%

The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer

Aghbash¹,

Hemmat²,

BARADARAN³

et al. 2022

Oncology Research

View full text Add to dashboard Cite

Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV are expressed in HPV-positive cancers and associated with the early cancer stages and the transformation of normal cells. The signaling pathways involved in the transformation of normal cells to cancerous form and the subsequently expressed programmed cell death-ligand 1 (PD-L1) on the surface of the transformed cells lead to a disruption in recognition of tumor cells by the immune cell system, including T lymphocytes and dendritic cells which lead to the development of cervical cancer malignancy.These cells also produce modest levels of cytokines during exhaustion, tumor-infiltrating T CD4+ cells with high levels of PD-1 and CD39 release considerable quantities of cytokines. The Wnt/β-catenin signaling pathway, which controls the expression of genes involved in the tumor cells' markers, is demonstrated to be one of the most potent cancer stimulants. It leads to the evasion of the tumor cells from immune cell detection and ultimately avoids being recognized by dendritic cells or T-cells. PD-L1, as an inhibitory immune checkpoint, is essential for controlling immune system activity by inhibiting T-cells' inflammatory function. In the present review, we looked into how Wnt/β-catenin affects the expression of PD-L1 and related genes like c-MYC in cancer cells and its role in the development of HPV-induced malignancy. We hypothesized that blocking these pathways could be a potential immunotherapy and cancer prevention method. Abbreviation List APCs Antigens presenting cells APC Adenomatous polyposis coli SATB1 AT-rich sequence binding protein-1 β-TrCP Beta-transducing repeat-containing protein Brg-1 Brahma-related gene 1 CD Cluster of differentiation c-MYC Cellular myelocytomatosis CIN Cervical intraepithelial neoplasia CREPT Cell cycle-related and expression elevated protein in tumor CBP/p300 CREB-binding protein CK1 Casein kinase 1

show abstract

Section: Pd-1/pd-l1 Axis' Impact On T-cd4+ and T-cd8+ Functionmentioning

confidence: 93%