Correlation between wall shear and intimal thickness at a coronary artery branch

Friedman, Morton H.; Bargeron, C. B.; Deters, O. J.; Hutchins, Grover M.; Mark, F.

doi:10.1016/0021-9150(87)90090-6

Cited by 175 publications

(78 citation statements)

References 10 publications

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“…[1][2][3][4]10 Several factors may explain this finding. First, in contrast with our global type of analysis, the circumferentially averaged data do not account for longlasting natural variations in SS over the circumference.…”

Section: Local Effectsmentioning

confidence: 89%

“…One such factor is the local shear stress (SS) induced by blood flow on the vessel wall. Indeed, several investigators showed that the deposition of atherosclerotic plaque is increased at natural average low SS locations, [1][2][3][4] implying an inverse relation between wall thickness (WT) and SS.…”

mentioning

confidence: 99%

“…In vitro studies determined WT and SS relations in casts derived from autopsy specimens. 4 To study SS, WT, and remodeling and their mutual relations in individual patients we applied a newly developed 3D arterial reconstruction technique 9 using angiography and IVUS combined with computational fluid dynamics (CFDs). Previously, we confirmed that atherosclerotic plaques were located at the low SS locations for a single patient.…”

mentioning

confidence: 99%

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Extension of Increased Atherosclerotic Wall Thickness Into High Shear Stress Regions Is Associated With Loss of Compensatory Remodeling

et al. 2003

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Section: Local Effectsmentioning

confidence: 89%

mentioning

confidence: 99%

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confidence: 99%

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Extension of Increased Atherosclerotic Wall Thickness Into High Shear Stress Regions Is Associated With Loss of Compensatory Remodeling

et al. 2003

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“…In both the coronary artery and the aorta, a negative association between shear stress and intimal thickness was indicated. [23][24] Unlike the TA, the AA contains the renal, mesenteric and iliac artery bifurcations. The coronary arteries are of smaller caliber than the aorta.…”

Section: Discussionmentioning

confidence: 99%

Histological topographical comparisons of atherosclerosis progression in juveniles and young adults

Homma

Troxclair

Zieske³

et al. 2008

Atherosclerosis

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“…Postmortem anatomical studies (3) and noninvasive in vivo imaging (4) in human subjects have shown that the early lesions of atherosclerosis are located preferentially in the vicinity of branch points, the outer wall of bifurcations, and the inner wall of curvatures, arterial geometries that are characterized by disturbed blood flow patterns. This striking correlation between regional hemodynamics and atherosclerosis (5,6) has motivated various studies that have attempted to define a mechanistic role for hemodynamic forces in the pathogenesis of atherosclerosis (for reviews see refs. [7][8][9][10].…”

mentioning

confidence: 99%

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature

Dai

Kaazempur-Mofrad

Natarajan

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

597

509

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Atherosclerotic lesion localization to regions of disturbed flow within certain arterial geometries, in humans and experimental animals, suggests an important role for local hemodynamic forces in atherogenesis. To explore how endothelial cells (EC) acquire functional͞dysfunctional phenotypes in response to vascular region-specific flow patterns, we have used an in vitro dynamic flow system to accurately reproduce arterial shear stress waveforms on cultured human EC and have examined the effects on EC gene expression by using a high-throughput transcriptional profiling approach. The flow patterns in the carotid artery bifurcations of several normal human subjects were characterized by using 3D flow analysis based on actual vascular geometries and blood flow profiles. Two prototypic arterial waveforms, ''athero-prone'' and ''athero-protective,'' were defined as representative of the wall shear stresses in two distinct regions of the carotid artery (carotid sinus and distal internal carotid artery) that are typically ''susceptible'' or ''resistant,'' respectively, to atherosclerotic lesion development. These two waveforms were applied to cultured EC, and cDNA microarrays were used to analyze the differential patterns of EC gene expression. In addition, the differential effects of atheroprone vs. athero-protective waveforms were further characterized on several parameters of EC structure and function, including actin cytoskeletal organization, expression and localization of junctional proteins, activation of the NF-B transcriptional pathway, and expression of proinflammatory cytokines and adhesion molecules. These global gene expression patterns and functional data reveal a distinct phenotypic modulation in response to the wall shear stresses present in atherosclerosis-susceptible vs. atherosclerosisresistant human arterial geometries.

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Correlation between wall shear and intimal thickness at a coronary artery branch

Cited by 175 publications

References 10 publications

Extension of Increased Atherosclerotic Wall Thickness Into High Shear Stress Regions Is Associated With Loss of Compensatory Remodeling

Extension of Increased Atherosclerotic Wall Thickness Into High Shear Stress Regions Is Associated With Loss of Compensatory Remodeling

Histological topographical comparisons of atherosclerosis progression in juveniles and young adults

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature

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