Correlation between vitamin D deficiency and fasting blood glucose levels in obese children

Juliaty, Aidah; Mutmainnah,; Daud, Dasril; Lisal, Johan Setyawan

doi:10.1016/j.clnesp.2021.06.022

“…(2) Insufficient absorbable vitamin D and calcium: most of the obese children included in this paper were artificially fed within 1 year of age. (3) The obese children generally grow faster than children of their peer and need more vitamin D. (4) The fat metabolism of the obese children interrupts the metabolism of vitamin D. In recent years, studies have shown that there is a negative correlation between vitamin D and obesity [ 21 ]. After a 10% weight loss, a low-calorie diet increased 25(OH)D levels, and this increase was primarily associated with improvements in insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Lifestyle Improvements and Vitamin D Supplementation Play an Important Role in the Prevention of Childhood Diabetes

Xu

¹

,

Yin

²

,

Yi

³

et al. 2022

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Objective. This study was to investigate the characteristics of insulin secretion and the 25-hydroxyvitamin D3 (25(OH)D3) levels in children with obesity. Methods. A retrospective analysis was conducted among children who underwent health checkups in the pediatric healthcare department of our hospital from January 2018 to January 2021, and they were divided into a normal group and an obese group according to their BMI. The insulin secretion and the 25(OH)D3 levels of the two groups of children were compared. A total of 721 children were included in the study, including 591 in the normal group and 130 in the obese group, with an obesity rate of 18.03%. Results. The blood glucose of the normal group was 4.55 ± 1.75 mmol/L, and the 2 h PG was 7.51 ± 2.11 mmol/L; in the obesity group, they were 6.03 ± 2.16 mmol/L and 8.92 ± 3.24 mmol/L, respectively. The FPG and 2 h PG in the obese group were significantly higher than those in the normal group (all P < 0.05 ). The incidence of IFG/IGT in the normal group was 5.24% (31/591), and the incidence of DM was 3.71% (22/591); the incidence of IFG/IGT in the obese group was 14.62% (19/130), and the incidence of DM was 13.08% (17/130). The incidences of IFG/IGT and DM in the obese group were significantly higher than those in the normal group ( P < 0.05 ). The FINS of the children in the normal group was 18.46 ± 3.15 μU/mL, and the HOMA-IR was 2.64 ± 0.62 ; the above indicators in the obese group were 19.11 ± 4.72 μU/mL and 3.01 ± 0.83 , respectively. The FINS and HOMA-IR in the obese group were significantly higher than those in the normal group ( P < 0.05 ). The serum 25(OH)D3 level in the normal group was 28.15 ± 5.27 ng/mL, of which 556 cases were normal in 25(OH)D3 and 35 cases were deficient in 25(OH)D3. The serum 25(OH)D3 level in the obese group was 24.35 ± 4.51 ng/mL, of which 112 cases were normal in 25(OH)D3 and 18 cases were deficient in 25(OH)D3. The level of serum 25(OH)D3 in the normal group was significantly higher than that in the normal group, and the ratio of 25(OH)D3 deficiency was significantly lower than that in the normal group ( P < 0.05 ). Conclusions. The blood glucose level of childhood obesity was significantly increased, the incidence of abnormal glucose metabolism and diabetes was significantly increased, and the level of 25(OH) vitamin D3 was significantly decreased. Lifestyle improvements and vitamin D supplementation play an important role in the prevention of childhood diabetes. Because the major causes of childhood obesity are excessive caloric intake and lack of exercise, the most effective and direct measures to prevent obesity are a reasonable lifestyle, reasonable eating habits, and moderate exercise. Although genetics are critical, there is no reliable way to eliminate obesity genes in the human body. Therefore, the role of obesity genes is required to be ultimately eliminated by reduced caloric intake and increased physical activity.

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“…We also found 14 articles from citations and hand searching, which resulted in an additional manuscript (15) . Notable exclusions include one study which did not specify the vitamin D cut-off value (34) , one study that included Dutch residents of Indonesian ethnicity (35) , two studies (36,37) that were generated from the same dataset (38) , one poster presentation (39) that were ultimately published as a full A c c e p t e d A r t i c l e paper (40) , and five studies (41)(42)(43)(44)(45) were also excluded as they were part of Southeast Asian Nutrition Surveys (SEANUTS) study (15) . Therefore, seven studies (15,38,40,(46)(47)(48)(49) are available for systematic review and meta-analysis (Supplementary Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Fourteen additional articles were collected through citation and hand searching, one of which was included in our meta-analysis [ 15 ]. Notable exclusions included one study that did not specify the vitamin D cutoff [ 34 ], one study that included Dutch residents of Indonesian ethnicity [ 35 ], 2 studies [ 36 , 37 ] generated from the same dataset [ 38 ], one poster presentation [ 39 ] that was published as a full paper [ 40 ], and 5 studies [ 41 - 45 ] that were part of the Southeast Asian Nutrition Surveys (SEANUTS) study [ 15 ]. Therefore, 7 studies [ 15 , 38 , 40 , 46 - 49 ] were subjected to systematic re vie w and meta-analysis ( Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Vitamin D deficiency is a public health emergency among Indonesian children and adolescents: a systematic review and meta-analysis of prevalence

Octavius

¹

,

Shakila

²

,

Meliani

³

et al. 2023

Ann Pediatr Endocrinol Metab

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“…with a higher mean value of fasting glucose in obese children with VDD (signi cant p=0.031). 30 According to one study, a lower level of 25(OH)D was related to hyperglycemia and increased insulin. 21 Added to this , in another study there was a negative correlation between 25(OH)D and HOMA-IR (p=0.016) and insulin (p=0.015).…”

Section: Resultsmentioning

confidence: 99%

Metabolic Syndrome and Hypovitaminosis D in Children and Adolescents: A Systematic Review

Martins

¹

,

Silva

²

,

Santos

³

et al. 2023

Preprint

0

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Determine the correlation between metabolic syndrome and hypovitaminosis D in children and adolescents. Data source: systematic review of the literature, PROSPERO registry: CRD42022353545, performed through the evaluation of studies indexed between 2012 and 2022, in the PubMed, ScienceDirect and Web of Science databases. Texts in English and Portuguese were searched for by the DeCS/MeSH descriptors “Metabolic Syndrome” AND “Vitamin D Deficiency” AND Child AND Adolescent. 163 articles were found. After analysis and application of the eligibility criteria, 30 articles were selected. Data synthesis: 28 were observational and 2 were randomized clinical trials. The samples ranged from 29 to 6589 children and adolescents and the age group between 3 and 18 years. A direct relationship between metabolic syndrome and hypovitaminosis D in pediatrics was identified in 15 studies. Regarding the components of the syndrome, 14 articles highlighted obesity, with a higher frequency of vitamin D deficiency or insufficiency in obese children and adolescents. In addition, 10 articles observed an inverse relationship between 25(OH)D levels and glycemic levels. Finally, vitamin D supplementation was associated with improvement in syndrome parameters. Conclusions: Thus, the relationship between metabolic syndrome and hypovitaminosis D in pediatrics is evident. Preventive measures are necessary in order to prevent early and future cardiometabolic complications.

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Correlation between vitamin D deficiency and fasting blood glucose levels in obese children

Cited by 7 publications

References 7 publications

Lifestyle Improvements and Vitamin D Supplementation Play an Important Role in the Prevention of Childhood Diabetes

Lifestyle Improvements and Vitamin D Supplementation Play an Important Role in the Prevention of Childhood Diabetes

Vitamin D deficiency is a public health emergency among Indonesian children and adolescents: a systematic review and meta-analysis of prevalence

Metabolic Syndrome and Hypovitaminosis D in Children and Adolescents: A Systematic Review

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