Correlation between veterinary antimicrobial use and antimicrobial resistance in food-producing animals: a report on seven countries

Chantziaras, Ilias; Boyen, Filip; Callens, Bénédicte; Dewulf, Jeroen

doi:10.1093/jac/dkt443

Cited by 475 publications

(346 citation statements)

References 49 publications

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“…Higher levels of fluoroquinolone resistance were detected in E. coli cultured from imported broiler chicken meat (22%), compared to Danish poultry meat (12%) and broiler chicken's faecal samples (7%). The correlation between the geographical source of isolates and resistance detected tends to follow fluoroquinolone usage or selection pressure (Chantziaras et al, 2014). After the USA banned the use of fluoroquinolones in food-producing animals in 2005, fluoroquinolone resistance in E. coli cultured from poultry decreased from 1% to 0% (Doyle et al, 2013;Tadesse et al, 2012).…”

Section: Quinolonesmentioning

confidence: 99%

Studies on avian pathogenic Escherichia coli in commercial broiler chicken in South East Queensland

Awawdeh¹,

Turni²,

Henning³

et al.

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Avian pathogenic Escherichia coli (APEC) is the causative agent of avian colibacillosis, a localised or systemic infection resulting in clinical diseases such as colisepticemia, chronic respiratory disease and swollen-head syndrome. Globally, avian colibacillosis is the leading cause of morbidity and mortality in poultry, and it has been associated with massive economic losses and welfare problems.This organism is of public health significance as APEC is communicable to humans. The diagnosis of avian colibacillosis relies on clinical signs, typical pathological lesions and culture of E. coli from affected tissue(s). Antimicrobial therapy is often used both for treatment and control. Previous overseas studies have characterised APEC and identified virulence genes (VGs) that can be used as molecular markers for the identification of APEC. Little is known about APEC in broiler chickens in Australia.The aim of this thesis was to gain a better understanding of the epidemiology of APEC in Australian broiler flocks and how factors including presence of VGs and phylogenetic group can improve the identification of this pathotype in Australia. Firstly, three faecal DNA extraction methods were evaluated. Faeces were collected from healthy chickens and chickens with colibacillosis from commercial broiler farms in South East Queensland (SEQ). The extracted DNA was screened by a pentaplex-PCR for five APEC-associated VGs (iroN, iutA, iss, hlyF and ompT). DNA extracted from E. coli isolates cultured from the cloaca and organs of the birds were screened using the same PCR.Repeated bead beating plus column elution was the preferred DNA extraction method, as it yielded good PCR quality and adequate quantity DNA. However, identifying APEC by direct detection of the five VGs from the faecal material was not feasible as all of these genes were also detected in all of the birds. However, the VGs were more commonly detected in E. coli isolates cultured from birds with colibacillosis.A cross-sectional study was performed to estimate APEC farm-level prevalence in healthy broiler chickens in SEQ and to identify potential risk factors associated with the carriage of APEC. At the farm-level, all of the 40 farms sampled were positive for APEC, that is at least one bird per farm carried APEC, while the within-farm prevalence was 63% (95% Confidence Interval: 55.8, 70.2).Higher APEC within-farm bird-level prevalence was significantly associated with the usage of well water as a source of drinking water, failure to disinfect the water line after each flock, farm visitors not showering before entering the shed, distances greater than 20 metres between the car park and the poultry shed and the presence of wild birds within 50 metres of the shed. Chlorinating the drinking water combined with automatic water filtration reduced within-farm bird-level APEC prevalence. Page | 3Therefore, based on the results concluded from the multivariable model, improving biosecurity and water treatments might reduce APEC prevalence, decrease the risk of co...

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Section: Quinolonesmentioning

confidence: 99%

Studies on avian pathogenic Escherichia coli in commercial broiler chicken in South East Queensland

Awawdeh¹,

Turni²,

Henning³

et al.

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“…Isolation of ARB is frequent in fresh and processed meat from slaughterhouses, processing plants, packaging materials and retail outlets (Aarestrup, 2004). There is a high degree of correlation between veterinary antimicrobial use and antimicrobial resistance in food-producing pigs, poultry, and cattle (Chantziaras et al, 2014). The overuse of drugs in veterinary practices related to food animals, pet, and human medical treatments contributes to bacterial mutation and acquired resistance (Holmes et al, 2016).…”

Section: Antibiotics Use and Antimicrobial Resistancementioning

confidence: 99%

A glimpse of the future in animal nutrition science. 1. Past and future challenges

et al. 2017

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-If the world population continues to increase exponentially, wealth and education inequalities might become more pronounced in the developing world. Thus, offering affordable, high-quality protein food to people will become more important and daunting than ever. Past and future challenges will increasingly demand quicker and more innovative and efficient solutions. Animal scientists around the globe currently face many challenging issues: from ensuring food security to prevent excess of nutrient intake by humans, from animal welfare to working with genetic-engineered animals, from carbon footprint to water footprint, and from improved animal nutrition to altering the rumen microbiome. Many of these issues are most likely to continue (or to exacerbate further) in the coming years, but animal scientists have many options to surmount the obstacles posed to the livestock industry through tools that are presently available. The frequency, interval, and intensity of livestock impacts, however, differ across regions, production systems, and among livestock species. These differences are such that the generalization of these issues is impossible and dangerous. For instance, when we discuss domesticated ruminant nutrition in the human food context, we look for the most efficient ruminant feeds that complement, rather than compete with, grains grown for direct human nutrition. Greater scrutiny and standardization are needed when developing and validating methodologies to assess short-and long-term impacts of livestock production. Failure in correctly quantifying these impacts may lead to disregard and disbelief by the livestock industry, increased public confusion, and the development of illusionary solutions that may amplify the impacts, thereby invalidating its original intent.Key Words: challenges, issues, livestock, ruminant, production Revista Brasileira de Zootecnia

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“…Extremely high rates of antimicrobial consumption have been recorded in aquaculture farming in middle and lowincome countries 43,44 . It is believed that growth in aquaculture production systems will increase the antimicrobial consumption and contamination of the aquatic environments with antimicrobial residues in future 45 .…”

Section: Use Of Antimicrobials In Animal Husbandrymentioning

confidence: 99%

Rational Use of Antimicrobials in Animal Production:A Prerequisite to Stem the Tide of Antimicrobial Resistance

Thakur

Panda

2017

Current Science

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Antimicrobial resistance (AMR) is a worldwide 'OneHealth' problem. The spread of AMR has limited the treatment options against infectious diseases. Inappropriate use of antimicrobials, is a major contributor for the development of AMR and its spread. In animal husbandry, antimicrobials are used for treating infectious diseases and in sub-therapeutic concentrations for growth promotion and disease prophylaxis. The use of antimicrobials in sub-therapeutic concentrations exerts selective pressure on bacteria and results in the emergence of bacterial strains resistant to one or more antimicrobials. The food animals raised on sub-optimal doses of antibiotics become reservoirs of resistant bacterial strains, transmitted subsequently to man and the environment. Various human, animal and environmental health agencies have decided to jointly address this problem. Establishment of integrated and harmonized AMR surveillance programmes, reduced use of antimicrobials in animal production, good governance of veterinary services, and development of new antimicrobials and their alternatives are some of the AMR management strategies in animals. Antibiotics are indispensable for human health; however, they should be totally banned in the food animals to preserve effectiveness of these drugs. In India, use of antimicrobials in food animals is limited for disease prophylaxis and growth promotion. However, absence of uniform regulations on the use of antimicrobials in animal production threatens the rationale use of these drugs in livestock.

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Correlation between veterinary antimicrobial use and antimicrobial resistance in food-producing animals: a report on seven countries

Cited by 475 publications

References 49 publications

Studies on avian pathogenic Escherichia coli in commercial broiler chicken in South East Queensland

Studies on avian pathogenic Escherichia coli in commercial broiler chicken in South East Queensland

A glimpse of the future in animal nutrition science. 1. Past and future challenges

Rational Use of Antimicrobials in Animal Production:A Prerequisite to Stem the Tide of Antimicrobial Resistance

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