Correlation between urinary cadmium and thyroid hormones in outdoor workers exposed to urban stressors

Rosati, Maria Valeria; Montuori, L; Caciari, Tiziana; Sacco, C; Marrocco, M.; Tomei, Gianfranco; Scala, Barbara; Sancini, A.; Anzelmo, Vincenza; Bonomi, S.; Tomei, Francesco

doi:10.1177/0748233715602833

Cited by 24 publications

(14 citation statements)

References 25 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These gender-based differences are difficult to explain and may be the consequence of toxicokinetics and hormonal differences between sexes that certainly influence observed responses. Studies by Rosati et al [ 32 ] and Jurdziak et al [ 33 ] have added the factor of occupational exposure to Cd. An outdoor study on 277 individuals of both sexes exposed to urban pollutants has found a negative correlation between urinary Cd levels and free T3 and T4 levels and a positive correlation between Cd urinary levels and TSH levels, showing that occupational exposure to the low Cd concentration present in urban air affects thyroid function [ 32 ].…”

Section: Cadmium Effects On Thyroid Functionmentioning

confidence: 99%

“…Studies by Rosati et al [ 32 ] and Jurdziak et al [ 33 ] have added the factor of occupational exposure to Cd. An outdoor study on 277 individuals of both sexes exposed to urban pollutants has found a negative correlation between urinary Cd levels and free T3 and T4 levels and a positive correlation between Cd urinary levels and TSH levels, showing that occupational exposure to the low Cd concentration present in urban air affects thyroid function [ 32 ]. Another study on workers occupationally exposed to Pb, Cd, and arsenic also confirmed that higher blood Cd concentrations amplify the risk of abnormal hormonal thyroid function evaluated by elevated TSH levels [ 33 ].…”

Section: Cadmium Effects On Thyroid Functionmentioning

confidence: 99%

See 1 more Smart Citation

Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

Buha

Matović

Antonijević

et al. 2018

IJMS

159

View full text Add to dashboard Cite

Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.

show abstract

Section: Cadmium Effects On Thyroid Functionmentioning

confidence: 99%

Section: Cadmium Effects On Thyroid Functionmentioning

confidence: 99%

Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

Buha

Matović

Antonijević

et al. 2018

IJMS

159

View full text Add to dashboard Cite

show abstract

“…For average UCd level, the odds of female were lower than that of males (Table 2); the reason might come from the sample sizes. Moreover, it has been found that endogenous hormones contribute to the UCd burden [43,44]. The participants in our survey were all native residents, and most had been living in the study site more than 25 years.…”

Section: Discussionmentioning

confidence: 99%

An assessment of sensitivity biomarkers for urinary cadmium burden

Wang

et al. 2020

BMC Nephrol

View full text Add to dashboard Cite

Background: Excess cadmium (Cd) intake poses a general risk to health and to the kidneys in particular. Among indices of renal dysfunction under Cd burden measures are the urinary N-acetyl-β-D-glucosidase (UNAG) and urinary β 2-microglobulin (Uβ 2-MG) enzymes. However, the end-pointed values and the Cd burden threshold remain controversial because the scopes fluctuate widely. Methods: To ascertain the clinical benchmark dose of urinary Cd (UCd) burden for renal dysfunction, 1595 residents near a Cd site were surveyed. Urine was sampled and assayed. A benchmark dose low (BMDL) was obtained by fitting UCd levels and index levels. Results: We found that over 50% of the subjects were suffering from Cd exposure as their UCd levels far exceeded the national standard threshold of 5.000 μg/g creatinine (cr). Further analysis indicated that Uβ 2-MG was more sensitive than UNAG for renal dysfunction. The BMDL for UCd was estimated as 3.486 U/g cr (male, where U is unit of enzyme) and 2.998 U/g cr (female) for UNAG. The BMDL for Uβ 2-MG, which is released into urine from glomerulus after Cd exposure, was found to be 2.506 μg/g cr (male, where μg is the unit of microglobulin) and 2.236 μg/g cr (female). Conclusions: Uβ 2-MG is recommended as the sensitivity index for renal dysfunction, with 2.2 μg/g cr as the threshold for clinical diagnosis. Our findings suggest that Uβ 2-MG is the better biomarker for exposure to Cd.

show abstract

Section: Discussionmentioning

confidence: 99%