Correlation between umbilical cord blood lipid profile and neonatal birth weight

Aletayeb, Seyyed Mohammad Hassan; Dehdashtian, Masoud; Aminzadeh, Majid; Moghaddam, Abdul Rahman Emami; Mortazavi, Maziyar; Malamiri, Reza Azizi; Habibzadeh, Mahshad; Javaherizadeh, Hazhir

doi:10.1016/j.pepo.2013.08.004

Cited by 25 publications

(25 citation statements)

References 21 publications

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“…6 However, in a study involving also very preterm babies (born between 28 th and 42 th week), umbilical blood lipid concentration (TC, HDL, LDL, very low density lipoprotein, TG) did not differ significantly between genders. 11 In the present study, a significant positive correlation was found between the TG concentration and gestational age, which is consistent with observations made by other researchers. 7,12 However, it should be noted that in a study by Kharb et al, the opposite trend was reported.…”

Section: Discussionsupporting

confidence: 93%

“…The mean serum lipid levels (TG, TC, LDL, and very low density lipoprotein) were higher in groups with low birth weight (<2500 g) and high birth weight (>4000 g) than in the group with normal weight. 11 In the previously mentioned Iranian study, the TG concentrations in babies who were small for their gestational age were significantly higher than in the babies with the appropriate weight for their gestational age. 10 Moreover, in the children who were small for their gestational age, the highest TG concentrations and the lowest LDL concentrations were noticed in comparison to the group with the ageappropriate weight.…”

Section: Discussionmentioning

confidence: 76%

“…7 In different studies, TC and LDL were significantly lower in neonates whose mothers were younger than 30 years of age than in the case of older mothers. 11 Maternal age was also inversely associated with the newborns' TG and HDL concentrations. 12…”

Section: Discussionmentioning

confidence: 95%

“…27 In another study, TC and LDL levels were significantly higher in subjects whose mothers' BMI was ≤25 kg/m 2 compared to >25 kg/m 2 . 11 Some researchers have concluded that in developed countries pre-pregnancy BMI is a significant predictor of fetal growth. 28 A relationship between low maternal preconceptional BMI (<20 kg/m 2 ) and fetal growth restriction and pre-term delivery has been documented.…”

Section: Discussionmentioning

confidence: 99%

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Cord blood lipid profile in healthy newborns: A prospective single-center study

2018

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Cord blood lipid profile in healthy newborns: A prospective single-center study

2018

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“…Chandrika et al reported that abnormal intrauterine milieu created by maternal changes during gestation may bear an impact on lipid metabolism in neonates, which may account for their differences in lipid profile and anthropometry at birth. In our study lipid values were higher in SGA babies than AGA babies which was similar to other studies like Nayak et al, Aletayab et al 17,18 This study showed no statistically significant gender difference for lipid profile, atherogenic indices which is similar to Kenchappa et al, Pratinidhi et al 19,20 But Kelishadi et al had shown that in female newborns, TC, LDL and HDL were significantly higher compared to male. 21 From the results, it is observed that lipid profile values in the neonate are much different from adults.…”

Section: Discussionsupporting

confidence: 91%

Cord blood lipid profile in late preterm and term neonates

Yashodha

Anjum

2018

Int J Contemp Pediatr

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Background: Atherosclerotic cardiovascular diseases are the major causes of mortality and morbidity both in developed and developing countries. High concentrations of lipids in neonates with low gestational age may increase the risk of cardiovascular diseases in the future. It has been suggested that early diagnosis along with appropriate diet and drug therapy may provide an opportunity for long term amelioration of risk factors that contribute to atherosclerosis and cardiovascular diseases in adult life. This study is conducted to compare lipid profile and atherogenic indices in late preterm and term neonates.Methods: It is a prospective comparative study conducted over a period of 12 months in a tertiary care hospital, Bangalore. A total of 170 neonates between 34 to 42 weeks were included in the study. Umbilical cord blood was collected immediately after delivery and lipid values were measured. Atherogenic indices were calculated. Results: Out of 170 neonates, 93 (54.7%) were male and 77 (45.3%) were female. 88 (55%) were late preterm and 72 (45%) were term. The cord blood lipid levels were not affected by the gender of the neonates. TG, TC, LDL, VLDL, LDL/HDL, TC/HDL were higher in late preterm babies compared to term babies (p <0.05), HDL levels were not statistically significant. The mean serum lipid levels (TG, TC, LDL and VLDL) and atherogenic indices were higher in SGA babies than AGA, but HDL levels were not statistically significant. (p >0.05)Conclusions: Lipid levels are inversely correlated with the gestational age. This could be regarded as a risk factor for development of atherosclerosis and cardiovascular diseases in later life.

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Maternal hypercholesterolemia during gestation is associated with elevated lipid levels of two-day-old neonates

et al. 2023

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Maternal hypercholesterolemia (MHC) during pregnancy is associated with the risk of developing aortic lesions in fetuses. There is also a possibility of faster progression of atherosclerosis in offspring born to hypercholesterolemic mothers (HCM) during their adulthood. We investigated whether elevated maternal cholesterol levels during pregnancy in uence the lipid levels in offspring. We analyzed the lipid pro le of mothers during the three trimesters, cord blood (CB) at birth, and neonatal blood (NB) on Day 2 postpartum in the offspring. Cholesterol levels of HCM signi cantly increased throughout gestation when compared to normocholesterolemic mothers (NCM). CB lipid levels of newborns of HCM were similar to the newborns of NCM. While NB of offsprings of HCM had elevated levels of triglycerides (TG) (p<0.01) and very low-density lipoprotein (VLDL) (p<0.01) when compared to the offspring of NCM. MHC also resulted in low newborn birthweight (p<0.05) and low placental e ciency (ratio of newborn birth weight to placental weight) (p<0.01) but no change was observed in umbilical cord length or placental weight.Immunohistochemical analysis revealed no signi cant changes in the protein expression of genes involved in TG metabolisms such as LDLR, VLDLR, CETP, and PPARG. We report that MHC in mothers decreases placental e ciency and newborn birthweight while increasing lipid levels in neonates on the second postpartum day. Given that TG levels modulate the circulating Low-Density lipoproteins, the increase in these levels in neonates gains importance. Whether these consistently high levels cause atherosclerosis in early adulthood warrants further investigation.

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Correlation between umbilical cord blood lipid profile and neonatal birth weight

Cited by 25 publications

References 21 publications

Cord blood lipid profile in healthy newborns: A prospective single-center study

Cord blood lipid profile in healthy newborns: A prospective single-center study

Cord blood lipid profile in late preterm and term neonates

Maternal hypercholesterolemia during gestation is associated with elevated lipid levels of two-day-old neonates

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