Correlation between TSH levels and quality of life among subjects with well-controlled primary hypothyroidism

Morón-Díaz, Marta; Saavedra, Pedro; Alberiche-Ruano, María Pino; Rodríguez-Pérez, Carlos; López-Plasencia, Yaiza; Marrero-Arencibia, Dunia; González-Lleó, Ana M.; Boronat, Mauro

doi:10.1007/s12020-020-02449-4

Cited by 15 publications

(15 citation statements)

References 32 publications

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“…Although in our study, different variables were assessed, such as tobacco consumption, educational level, employment status, sexual orientation, civil status, or cohabitation, we found no relation with HRQOL in hypothyroid women. In line with Morón et al [41], our results showed no relation between HRQOL and tobacco consumption, living arrangement, or educational level. Rakhshan et al observed a significant relationship between educational level and mental health, but it disappeared when assessing its relationship with quality of life.…”

Section: Discussionsupporting

confidence: 92%

“…On the one hand, climacteric and menopause trigger a decline in the quality of life in women [43,44]; on the other hand, a previous study reported that hypothyroid women showed a higher prevalence of sexual disorder than non-hypothyroid women [11]. It is noteworthy that the mean age of our sample was lower than in other studies about HRQOL and hypothyroidism [31,38,41,45].…”

Section: Discussionmentioning

confidence: 51%

“…On the other hand, with a smaller sample, Rakhshan et al observed no difference in the quality of life between patients with hypothyroidism and a healthy population [32]; however, they reported lower scores in mental health. None of the mentioned studies was sex-specific-all included men in their samples [19,22,32,[38][39][40][41]. Therefore, there could be differences between sexes that may explain the differences with our results.…”

Section: Discussionmentioning

confidence: 68%

“…Our data show that HRQOL in levothyroxine-treated hypothyroid women is worse than in controls. Other studies also found a worse HRQOL in hypothyroid patients [19,40,41], although they used reference values for the general population instead of control groups. On the other hand, with a smaller sample, Rakhshan et al observed no difference in the quality of life between patients with hypothyroidism and a healthy population [32]; however, they reported lower scores in mental health.…”

Section: Discussionmentioning

confidence: 96%

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Health-Related Quality of Life in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case–Control Study

Romero-Gómez

Guerrero-Alonso

Carmona‐Torres

et al. 2020

JCM

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The use of levothyroxine is not always related to the elimination of the symptoms of hypothyroidism. The aim of this study is to compare the health-related quality of life (HRQOL) of a group of hypothyroid women under levothyroxine treatment with that of a group of non-hypothyroid women. Methodology: A case–control study was performed. We used convenience sampling. The case group consisted of 152 levothyroxine-treated hypothyroid women; the control group consisted of 238 women without hypothyroidism disorders. All of the participants were euthyroid according to the clinical practice guidelines. We used as instruments the Short Form-12 questionnaire (SF-12v1) and a sociodemographic questionnaire. Results: Hypothyroid women scored significantly lower in HRQOL in SF-12v1 mental and physical components than the control group (mental component summary: 41.23 ± 12.12 vs. 46.45 ± 10.22, p < 0.001; physical component summary: 49.64 ± 10.16 vs. 54.75 ± 5.76, p < 0.001). body mass index (BMI) and age showed an influence on the physical component (p < 0.001 in both variables). Adjusted for age and BMI, hypothyroidism was still related to worse scores (p < 0.001). Conclusion: Despite being euthyroid, women with hypothyroidism showed a poorer quality of life than women without hypothyroidism. Health professionals need to assess the HRQOL of women with hypothyroidism. Further research on HRQOL and hypothyroidism is needed.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 96%

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Health-Related Quality of Life in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case–Control Study

Romero-Gómez

Guerrero-Alonso

Carmona‐Torres

et al. 2020

JCM

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“…A similar lack of influence of the target TSH level was obtained in Roos et al’s (2005) double-blind RCT [ 49 ] and in Walsh et al’s crossover RCT (69). In contrast, Moron-Diaz et al found that even within the TSH reference range, lower TSH levels were associated with better QoL with adequately treated primary hypothyroidism [ 93 ]. Similarly, Mithal et al (2014) observed that the mean SF-36 Emotional Health and Physical Health scores were worse ( p = 0.0278 and 0.0763, respectively) among “undertreated” patients (TSH > 4 mU/L) and “overtreated” patients (TSH < 0.40 mU/L) patients when compared with patients with a normal TSH level [ 71 ].…”

Section: Quality Of Life In Patients Treated For Hypothyroidismmentioning

confidence: 99%

What Is the Quality of Life in Patients Treated with Levothyroxine for Hypothyroidism and How Are We Measuring It? A Critical, Narrative Review

Borson‐Chazot

Terra

Goichot

et al. 2021

JCM

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Thyroid hormone replacement therapy (THRT, generally using oral levothyroxine (LT4)) is a safe, effective means of treating hypothyroidism. However, a proportion of LT4-treated patients with biochemically normal thyroid function tests complain of persistent symptoms that impact their health-related quality of life (QoL). The objectives of this critical, narrative review of the literature were to identify studies of QoL in LT4-treated patients with hypothyroidism, examine the instruments used to measure QoL, determine whether normal QoL is restored by THRT, and identify factors associated with QoL. The PubMed database was searched from 1 January 2000 to 31 December 2020. A total of 809 publications were screened, 129 full-text articles were retrieved, and 58 were analyzed. The studies of overt hypothyroidism evidenced an improvement in psychological and emotional well-being after three to six months of THRT with LT4, although contrasting results were found for patients with subclinical hypothyroidism. Combination treatment with LT4 and liothyronine was not generally associated with better QoL. In hypothyroidism, QoL appears to be influenced by a number of physiological, behavioral, cognitive and/or lifestyle factors that are not strictly related to thyroid hormone levels.

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Hypothyroidism

Chaker

Razvi

Benseñor

et al. 2022

Nat Rev Dis Primers

145

108

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Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate. Clinical manifestations of hypothyroidism range from life threatening to no signs or symptoms. The most common symptoms in adults are fatigue, lethargy, cold intolerance, weight gain, constipation, change in voice, and dry skin, but clinical presentation can differ with age and sex, among other factors. The standard treatment is thyroid hormone replacement therapy with levothyroxine. However, a substantial proportion of patients who reach biochemical treatment targets have persistent complaints. In this Seminar, we discuss the epidemiology, causes, and symptoms of hypothyroidism; summarise evidence on diagnosis, long-term risk, treatment, and management; and highlight future directions for research.

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Correlation between TSH levels and quality of life among subjects with well-controlled primary hypothyroidism

Cited by 15 publications

References 32 publications

Health-Related Quality of Life in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case–Control Study

Health-Related Quality of Life in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case–Control Study

What Is the Quality of Life in Patients Treated with Levothyroxine for Hypothyroidism and How Are We Measuring It? A Critical, Narrative Review

Hypothyroidism

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