Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research

Abstract

Objective. It remains unknown whether obesity has an effect on the pituitary-thyroid feedback control axis in subclinical hypothyroidism (SCH). We aimed to investigate the association of thyroid homeostasis with obesity in a SCH population. Methods. Our study consisted of a community-based and cross-sectional study from the Epidemiological Survey of Thyroid Diseases in Fujian Province, China. A total of 193 subjects with SCH (90 males and 103 females) without a history of treatment of thyroid disease, such as surgery, radiation, and thyroid hormone or antithyroid medication, were included in the present study. Indices of obesity, including body mass index (BMI), waist circumference (WC), and waist-height ratio (WHtR) were measured. Results. Our results showed that the secretory capacity of the thyroid gland (SPINA-GT) and Jostel’s thyrotropin index (TSHI) were negatively correlated with BMI, WC, and WHtR, whereas the reciprocal of the thyrotroph thyroid hormone resistance index (TTSI-1) was positively correlated with BMI (all p < 0.05 ). After adjustment for age, sex, smoking, iodine status, and glucolipid metabolism, the associations between TSHI, TTSI (reciprocal transformation), and BMI still persisted (all p < 0.05 ). Conclusions. These results suggest that low levels of thyroid homeostasis indexes may be associated with overall obesity in SCH, rather than central adiposity.

Increased Central and Peripheral Thyroid Resistance Indices During the First Half of Gestation Were Associated With Lowered Risk of Gestational Diabetes—Analyses Based on Huizhou Birth Cohort in South China

“…However, contradictory findings were reported in others (17,35,36). Similar to our findings in pregnant women, several crosssectional studies among Chinese population reported that a decreased sensitivity/increased resistance to thyroid hormones were associated with reduced risk of pre-diabetes (17), lowered levels of HbA1c (35), or body mass index (BMI) (36). A crosssectional study (17) among Chinese adults reported that per SD increase in TSHI, TT4RI, and parametric TFQI and decrease in FT3/FT4 were associated with decreased risk of prediabetes by 9%-11%.…”

“…Elevated indices of thyroid resistance has been observed to be associated with multiple unfavorable metabolic factors or disorders in general population including adipocyte fatty-acidbinding protein (34), obesity (15), type 2 diabetes, metabolic syndromes, or even diabetes-related mortality (14). However, contradictory findings were reported in others (17,35,36). Similar to our findings in pregnant women, several crosssectional studies among Chinese population reported that a decreased sensitivity/increased resistance to thyroid hormones were associated with reduced risk of pre-diabetes (17), lowered levels of HbA1c (35), or body mass index (BMI) (36).…”

“…A cross-sectional study ( 17 ) among Chinese adults reported that per SD increase in TSHI, TT4RI, and parametric TFQI and decrease in FT3/FT4 were associated with decreased risk of prediabetes by 9%–11%. Another community-based cross-sectional analysis ( 36 ) among 193 patients of SCH also indicated that the secretory capacity of the thyroid gland (SPINA-GT) and Jostel’s TSHI were significantly and negatively correlated with indices of obesity, suggesting low levels of thyroid homeostasis indices increased the risk of overall obesity in RTH. The discrepant findings might be related with different physiological status or severity of metabolic disorders of the studied populations.…”

Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study

“…This suggested that thyroid hormone resistance may be affected by fat accumulation. A previous study by Zhou et al found that obese patients had higher TSHI and TFQI levels compared to the control group, and TSHI and TFQI decreased significantly over time after bariatric surgery [ 41 ]. In addition, a cross-sectional analysis also showed that the secretory capacity of the thyroid gland (SPINA-GT) and TSHI were significantly negatively related to obesity indices, suggesting that obesity reduces levels of thyroid homeostasis indices [ 42 ].…”

Thyroid Feedback Quantile-Based Index Is Associated With Blood Pressure and Other Hemodynamic Measures: A Cross-sectional Study

“…Therefore, reduced thyroid hormone sensitivity caused by impaired expression of Dio2 may connected with hypertension. Thirdly, diabetes and obesity, which are also risk factors for hypertension, have been reported to be associated with impaired sensitivity of thyroid hormones 17,36 . Although we have excluded participants with diabetes, adjusted multiple metabolic variables, and conducted subgroup analyses stratified by BMI levels, there was still possibility that metabolic disorders served as cross-talk between TFQI and blood pressure.…”