Correlation between the solid state of lipid coating and release profile of API from hot melt coated microcapsules

Salar-Behzadi, Sharareh; Corzo, Carolina; Schaden, Lisa; Laggner, Peter; Zimmer, Andreas

doi:10.1016/j.ijpharm.2019.05.036

Cited by 13 publications

(12 citation statements)

References 35 publications

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“…In this process, as the name implies, meltable CoM, in the molten state, is applied onto substrate particle that solidifies upon cooling. The process uses meltable CoMs with low melting point, usually lipid or waxes [30][31][32][33] . The process requirement is the meltable CoMs had to be heated to molten state for having their solution that then air-atomised and sprayed onto surface of moving solid substrate followed by cooling of the product 30,32,33 .…”

Section: Hmc Processes/ Technologiesmentioning

confidence: 99%

“…The process uses meltable CoMs with low melting point, usually lipid or waxes [30][31][32][33] . The process requirement is the meltable CoMs had to be heated to molten state for having their solution that then air-atomised and sprayed onto surface of moving solid substrate followed by cooling of the product 30,32,33 . Upon cooling, a continuous film forms on substrate that acts as moisture protection barrier coating or rate-controlling membrane for drug release 4,10 .…”

Section: Hmc Processes/ Technologiesmentioning

confidence: 99%

“…As a process requirement, during application the coating fluid is required to be maintained at a constant temperature that cannot exceed 150 °C 4,32,33 . Thus meltable materials having molten viscosity below 300 centipoises and melting points below 80 °C are generally suitable, as prior to spraying the molten CoMs are to be maintained at 40-60 °C above their melting point 4 .…”

Section: Hmc Processes/ Technologiesmentioning

confidence: 99%

“…Lipidic meltable CoMs are highly compatible with ingredients like artificial sweeteners, flavouring agents, surfactants and many others 4,32,33 . These processes are suitable for herbal and hygroscopic products 2,3 .…”

Section: Hmc Processes/ Technologiesmentioning

confidence: 99%

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Dry-Coating of Powder Particles is Current Trend in Pharmaceutical Field

Alli¹

2021

J. Drug Delivery Ther.

608

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Modification of surface attributes of particles, usually accomplished by coating, is desirous to enhance and maintain their usability. Coating is a multi-step process involves application of the coating material (CoM) onto the substrate, herein powder particles, where the process along with device/ equipment monitors surface attributes of the applied coating. Nowadays competitive market calls for cost cutting to survive product(s). Thus saving of energy and time, minimising number and quantity of additives, reducing and shortening process steps; consequently minimising the coating process cost are main goals while developing coating process for powder particle. Innovation of processes for dry-powder coating (DPC) along with their further development and refinement finds solution to said issues. Further, DPC process does not calls for liquid solvent or solution thus are viewed as cost-effective and environmentally safe, DPC process uses thermo-mechanical methods like mechanofusion, magnetic assisted impaction coating (MAIC), hybridization, rotating fluid-bed process, theta-composer, hot-melt coating (HMC), and many others. Besides these available are non-thermo-mechanical methods namely electrostatic coating; supercritical fluids (SCF) based methods like rapid expansion of supercritical fluid (RESF), gas anti-solvent (GAS), SCF anti-solvent, gas-saturated solution (GSS); vapour coating; and others. Basing on said thermo-mechanical and non-thermo-mechanical principle several DPC methods/ process had been reported in scientific literatures and patents. Said DPC method founds multidisciplinary applications like drug delivery and drug development. Diverse devices are there for the DPC process; their method of working, principle, limitations and benefits along with their applicability in pharmaceutical field are discussed and presented in this article. Keywords: Dry, particle, coating, pharmaceutical, process

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Section: Hmc Processes/ Technologiesmentioning

confidence: 99%

Section: Hmc Processes/ Technologiesmentioning

confidence: 99%

Section: Hmc Processes/ Technologiesmentioning

confidence: 99%

Section: Hmc Processes/ Technologiesmentioning

confidence: 99%

See 2 more Smart Citations

Dry-Coating of Powder Particles is Current Trend in Pharmaceutical Field

Alli¹

2021

J. Drug Delivery Ther.

608

View full text Add to dashboard Cite

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“…During the past several decades, polymeric excipients have provided numerous strategies for developing new dosage forms with all sorts of drug-controlled release profiles [ 1 , 2 , 3 , 4 ]. Among them, polymeric coating is one of the most popular strategies for modifying the drug release kinetics in both the traditional pharmaceutical industry and also the advanced laboratory nanomethods [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Particularly in nanopharmaceutics, the simple and robust nanocoating methods are highly desired [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed Ultra-Thin Coating of Ethyl Cellulose on Drug Nanoparticles for Improved Sustained Release

Huang

Hanlin

et al. 2020

Nanomaterials

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In nanopharmaceutics, polymeric coating is a popular strategy for modifying the drug release kinetics and, thus, new methods for implementing the nanocoating processes are highly desired. In the present study, a modified coaxial electrospraying process was developed to formulate an ultra-thin layer of ethyl cellulose (EC) on a medicated composite core consisting of tamoxifen citrate (TAM) and EC. A traditional single-fluid blending electrospraying and its monolithic EC-TAM nanoparticles (NPs) were exploited to compare. The modified coaxial processes were demonstrated to be more continuous and robust. The created NPs with EC coating had a higher quality than the monolithic ones in terms of the shape, surface smoothness, and the uniform size distribution, as verified by the SEM and TEM results. XRD patterns suggested that TAM presented in all the NPs in an amorphous state thanks to the fine compatibility between EC and TAM, as indicated by the attenuated total reflection (ATR)-FTIR spectra. In vitro dissolution tests demonstrated that the NPs with EC coating required a time period of 7.58 h, 12.79 h, and 28.74 h for an accumulative release of 30%, 50%, and 90% of the loaded drug, respectively. The protocols reported here open a new way for developing novel medicated nanoparticles with functional coating.

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