Correlation between the sequential ingrowth of afferents and transient patterns of cortical lamination in preterm infants

Kostović, Ivica; Judaš, Miloš

doi:10.1002/ar.10069

Cited by 188 publications

(142 citation statements)

References 49 publications

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“…28 It has been known that cortical layer IV is a primary site for thalamocortical connections. 29 Moreover, abnormalities in subcortical structure such as fragile X syndrome have been reported in MR. [30][31][32] Abnormalities in subcortical structure might also be a possible cause of the abnormal cortical folding pattern in MR.…”

Section: Discussionmentioning

confidence: 99%

Reduced Cortical Folding in Mental Retardation

Zhang¹,

Zhou²,

Yu³

et al. 2010

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:MR is a developmental disorder associated with impaired cognitive functioning and deficits in adaptive behavior. With a 2D region of interestϪbased GI, a preliminary study reported significantly reduced gyrification in the prefrontal lobe in MR. The purpose of this study was to further investigate the abnormalities of cortical gyrification in MR and to explore the possible causes of these abnormalities.

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Section: Discussionmentioning

confidence: 99%

Reduced Cortical Folding in Mental Retardation

Zhang¹,

Zhou²,

Yu³

et al. 2010

AJNR Am J Neuroradiol

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“…23,24 In the immature human cerebrum, thalamocortical fibres grow through the intermediate zone as early as the 9th postovulatory week (POW), accumulate in the superficial part of the subplate zone between the 22nd and 24th POW, and penetrate the cortical plate between the 24th and 28th POW. 2,5,18,20 Thus, thalamocortical fibres represent a major input to the fetal cortex, while their prolonged presence ('waiting' period) within the subplate zone facilitates their interaction with subplate neurons and other cellular elements.…”

Section: Comparison Of Mri and Histological Findingsmentioning

confidence: 99%

Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants

Kostović

Judaš

2006

Develop Med Child Neuro

135

117

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The aim of this paper is to evaluate correlative magnetic resonance imaging (MRI) and histological parameters of development of cortical afferents during pathfinding and target selection in transient fetal cerebral laminas in human fetuses and preterm infants. The transient fetal subplate zone, situated between the fetal white matter (i.e. intermediate zone) and the cortical plate, is the crucial laminar compartment for development of thalamocortical and corticocortical afferents. The prolonged coexistence of transient (endogenously active) and permanent (sensorydriven) circuitry within the transient fetal zones is a salient feature of the fetal and preterm cortex; this transient circuitry is the substrate of cerebral functions in preterm infants. Another transient aspect of organization of developing fibre pathways is the abundance of extracellular matrix and guidance molecules in periventricular crossroads of projection and corticocortical pathways. Both the subplate zone and periventricular crossroads are visible on MRI in vivo and in vitro. Hypoxic-ischaemic lesions of periventricular crossroads are the substrate for motor, sensory, and cognitive deficits after focal periventricular leukomalacia (PVL). Lesions of distal portions of the white matter and the subplate zone are the substrate for diffuse PVL. The neuronal elements in transient fetal zones form a developmental potential for plasticity after perinatal cerebral lesions.Our understanding and interpretation of structural and functional consequences of cerebral lesions in human fetuses and preterm infants largely depends on knowledge of neurogenetic cellular events that can be demonstrated by in vivo neuroimaging. A necessary step in this approach is the correlation between magnetic resonance imaging (MRI) and histological organization during different phases of histogenesis. Namely, in the fetal cerebrum, early neurogenetic cellular events (i.e. proliferation, migration, aggregation, cell death, growth of axons, and the establishment of neuronal connections) proceed according to the specific timetable within transient, histologically recognizable fetal zones which do not have an equivalent in the adult brain. 1 During the last third of gestation, neuronal proliferation and migration are mostly completed 1 whereas the development of axonal pathways 2,3 and the differentiation of cortical neurons 4 become the most prominent neurogenetic events. Synaptogenesis continues as the dominant neurogenetic event during postnatal life. In addition to precise timing, these neurogenetic events also display a characteristic spatial occurrence: neuronal proliferation occurs in the ventricular and subventricular zones, whereas neuronal migration and growth of axons occur predominantly in the intermediate zone (the fetal white matter) and the subplate zone, which is situated between the intermediate zone and the cortical plate. 1 Neuronal differentiation and synaptogenesis begin in the transient subplate zone 5 and continue in the cortical plate. 1,5 Recent research in...

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“…After 22-24 WPC, due to the development of afferent input from thalamus to cortical sensory areas, [19][20][21] a new period of cortical functional organization begins. On the basis of experimental evidence 22,7 and our data on the simultaneous presence of thalamocortical axons in the subplate zone and in the cortical plate, we proposed that during the late fetal and early preterm period the coexistence of transient and permanent circuitry ( Fig.…”

Section: Late Fetal and Early Preterm Period: The Coexistence Of Tranmentioning

confidence: 99%

“…However, a new connectivity framework for possible functional involvement of the cerebral cortex develops during the midfetal period (15-20 WPC) due to concurrent increase in number of synapses 9,14 and thalamocortical afferents 14,[40][41][42] in the subplate zone 19,21,23 as well as the parallel development of efferent cortical pathways. 43 During the midfetal period, thalamocortical afferents which convey somatosensory information are still waiting within the subplate zone and did not reach their synaptic targets in the cortical plate.…”

Section: The Involvement Of Cortical Connections In Fetal and Pretermmentioning

confidence: 99%

“…WPC that neural circuitry begins to connect cerebral cortex with somatic periphery. 19,23 Two sets of data present the evidence for the first real functional involvement of the cerebral The organization of neural connections in the cerebrum of early preterm infant. The circuitry shema is superimposed on the coronal histological section through the right cerebral hemisphere stained with acetylcholinesterase (AChE) technique.…”

Section: The Involvement Of Cortical Connections In Fetal and Pretermmentioning

confidence: 99%

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Maturation of Cerebral Connections and Fetal Behavior

Kostović¹,

Judaš²

2008

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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Modern imaging methods enabled systematic studies of fetal behaviour as well as a continuation of that behaviour in prematurely born infants (for a review, see 1-4). The following question represents a great challenge for human developmental neurobiologist: what is the neurobiological basis of various behavioural patterns observed in human fetuses and preterm infants?2 First of all, it is essential to determine whether there is an early spontaneous (nonsensory-driven) activity and to what extent the cerebrum and the cerebral cortex may be involved. In addition, it is necessary to describe for each successive phase, the developmental status of neuronal circuitry and synaptic organization.In this review, we present evidence on the development of cortical connections during different phases of fetal development and evaluate a possible functional significance of cerebral involvement.

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Correlation between the sequential ingrowth of afferents and transient patterns of cortical lamination in preterm infants

Cited by 188 publications

References 49 publications

Reduced Cortical Folding in Mental Retardation

Reduced Cortical Folding in Mental Retardation

Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants

Maturation of Cerebral Connections and Fetal Behavior

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