Correlation between the Sedation-Agitation Scale and the Bispectral Index in ventilated patients in the intensive care unit

Bispectral Index Values, Sedation-Agitation Scores, and Plasma Lorazepam Concentrations in Critically Ill Surgical Patients

“…Also of concern was the high association between baseline 1-minute BIS and EMg. Arbour et al 19 previously reported positive association between the BIS-xp and EMg with an r 2 of 0.561, which was lower than the correlation found in our study. Several studies 15,16 The small number of patients may also limit the validity of our results.…”

“…Researchers evaluating BIS with other sedation scales have reported similarly poor correlation in ICU patients. 18 Although some other studies 10,[15][16][17]19 have shown stronger correlations between BIS and SAS scores, the R 2 values have still been less than 0.5, suggesting that less than 50% of the variability in BIS is explained by the SAS score. Finally, 2 studies 15,17 have shown correlations slightly greater than 0.5, but these included a subset of trauma patients from a larger study or they had BIS values associated with high EMg (>42 Hz) excluded.…”

Growing up with Midazolam in the Neonatal and Pediatric Intensive Care

“…Subjective measures include mood or sedation scores, for example the COMFORT scale, semisubjective measures are psychomotor testing and the objective measures include electroencephalography and bispectral index (BIS) measurements. The optimal measure, to monitor the pharmacodynamic endpoint still needs to be determined [59,60]. …”

Advances in Cerebral Monitoring for the Patient with Traumatic Brain Injury

“…[31][32][33] It must be noted that spEEG monitors do not evaluate responsiveness, and should be used in conjunction with subjective sedation assessment tools to get a more comprehensive picture of the patient's sedation status. 34 Suppression-ratio from spEEG can be used to monitor patients who are in burst-suppression (eg, pentobarbital coma). 35 …”