Correlation Between the Presence of Stromal Myofibroblasts and the Proliferative Potential of Odontogenic Keratocyst and Ameloblastoma

Abstract

Odontogenic keratocyst (OKC), and ameloblastoma (AB) aggressive epithelial odontogenic tumors with a high recurrence rate though, their aggressive nature are not totally understood, Many epithelial tumors are characterized by stromal reaction, Myofibroblast is one of stromal component that could contribute to the biologic behavior of these lesions, Fifteen cases of AB and OKC were operated on under general anesthesia, all cases were subjected to immunohistochemical staining with alpha-smooth muscle actin and flow cytometry analysis, ameloblastoma showed expression of α muscle actin between the follicles as well as around the blood vessels, while in OKC the expression was mostly in connective tissue wall of cyst lining, as well as flow cytometry analysis showed tumors were diploid and showed a percentage of cells in S-phase higher than 26%. OKC had a higher value than AB but the values were close and statistically insignificant, we concluded that the immunohistochemical expression of MF in AB & OKC has insignificant difference may contribute to the similar proliferative potential of both AB& OKC, as well The high proliferation rate of OKC reinforces its classification as a benign odontogenic neoplasm rather than a cyst Objective To detect the proliferative potential of odontogenic keratocyst, versus ameloblastoma and their correlation to presence of stromal myofibroblasts (258)

Stromal Myofibroblast Density in Dentigerous Cyst, Odontogenic Keratocysts and Ameloblastoma: An Immunohistochemical Study

“…This was in agreement with Syamala et al, 2016 (9) and in contrary to the study of Ali et al, 2018 (5) who found a statistically significant higher difference in α-SMA immunoexpression in AB than in OKC. On the other hand, Eid et al, 2018 (15) found a slightly higher α-SMA expression in OKC than AB with a statistically non-significant difference. They attributed this to the similar proliferative potential of both AB and OKC.…”