Correlation between the presence of degenerated inclusion‐bearing cells in voided urine samples and the occurrence of polyomavirus infection

Abstract

There were not enough strong morphological and staining elements to state the origin of the degenerated cells or to describe the nature of the infection (viral or bacterial), given that these cells were undergoing an apoptotic process in post renal transplant patients.

Primary trichodysplasia spinulosa polyomavirus infection in a kidney transplant child displaying virus‐infected decoy cells in the urine

“…Although these cells did not stain with the diagnostic anti‐LargeT SV40 antibodies, they strongly reacted with anti‐TSPyV‐specific antibodies. Notably, the same degenerated cells had been previously identified at a frequency of about 20% in a KTR cohort showing no signs of TSPyV‐associated skin disease and had not been associated with TSPyV or any other viral infection . Altogether these findings are supportive of a model where TSPyV, similar to JCPyV and BKPyV, can be shed in the urine of KTRs even in the absence of any apparent symptomatic manifestations.…”

“…Notably, the same degenerated cells had been previously identified at a frequency of about 20% in a KTR cohort showing no signs of TSPyV-associated skin disease and had not been associated with TSPyV or any other viral infection. 16 Altogether these findings are supportive of a model where TSPyV, similar to JCPyV and BKPyV, can be shed in the urine of KTRs even in the absence of any apparent symptomatic manifestations. In HPyVinfected KTRs, the skin disease may, therefore, be the consequence of a primary infection occurring in an individual with such unusual immunosuppressed conditions.…”

Is There Still a Role for Urine Cytology in Kidney Transplantation? Experience Report in a Teaching Hospital

“…8 Polyomavirus BK (BKV) reactivation can be diagnosed by the detection of decoy cells (DCs) in urine tests. [7][8][9][10] Identification of DCs allows the selection of patients who are more prone to develop BKV-associated nephropathy (BKVAN), a condition that can lead to loss of graft function in up to 5% of renal transplant patients. 11 Cytomegalovirus (CMV), Herpesvirus, Human papillomavirus, and Candida sp.…”