2020
DOI: 10.1016/j.neuropharm.2019.107933
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Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species

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Cited by 156 publications
(198 citation statements)
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“…At 5-HT 2C receptors, 2C derivatives were shown to be partial or full agonists (Eshleman et al 2014;Moya et al 2007), and NBOMe derivatives were shown to be full agonists (Eshleman et al 2018;Jensen et al 2017). Consistent with the in vitro findings, psychedelic phenethylamines were shown to induce 5-HT 2A -dependent behaviors in vivo, such as wet dog shakes, back muscle contractions, and a head twitch response (Elmore et al 2018;Fantegrossi et al 2005;Halberstadt et al 2020;Halberstadt and Geyer 2014). In addition to interactions with serotonergic receptors, phenethylamine psychedelics have been shown to interact with other monoaminergic targets, including adrenergic, dopaminergic, and histaminergic receptors, monoamine transporters, and MAOs (Eshleman et al 2018;Kolaczynska et al 2019;Luethi et al 2018d;Noble et al 2018;Rickli et al 2015c;Wagmann et al 2019a).…”
Section: Mechanism Of Action Of Phenethylaminesmentioning
confidence: 64%
“…At 5-HT 2C receptors, 2C derivatives were shown to be partial or full agonists (Eshleman et al 2014;Moya et al 2007), and NBOMe derivatives were shown to be full agonists (Eshleman et al 2018;Jensen et al 2017). Consistent with the in vitro findings, psychedelic phenethylamines were shown to induce 5-HT 2A -dependent behaviors in vivo, such as wet dog shakes, back muscle contractions, and a head twitch response (Elmore et al 2018;Fantegrossi et al 2005;Halberstadt et al 2020;Halberstadt and Geyer 2014). In addition to interactions with serotonergic receptors, phenethylamine psychedelics have been shown to interact with other monoaminergic targets, including adrenergic, dopaminergic, and histaminergic receptors, monoamine transporters, and MAOs (Eshleman et al 2018;Kolaczynska et al 2019;Luethi et al 2018d;Noble et al 2018;Rickli et al 2015c;Wagmann et al 2019a).…”
Section: Mechanism Of Action Of Phenethylaminesmentioning
confidence: 64%
“…Besides motor activity, we examined the effects of LSD on head twitch, grooming, retrograde walking, and nose-poking behaviors. LSD and other psychedelics are well-known to stimulate head-twitch responses in mice [18, 45,48] and this response has been proposed as a proxy for hallucinations in humans [13]. Compared to the vehicle, LSD stimulated head-twitch responses to similar extents in WT and βArr1-KO mice.…”
Section: Discussionmentioning
confidence: 99%
“…Clinical research with newer lysergamides has yet to be carried out in detail but serotonergic hallucinogens such as LSD induce the head‐twitch response (HTR) in mice and rats, which reflects 5‐HT 2A receptor activation (the primary target of hallucinogens in the CNS) 25,26 . In addition to having the ability to differentiate between hallucinogenic and non‐hallucinogenic 5‐HT 2A receptor agonists, 27,28 the HTR assay also allows in vivo potencies to be compared in a manner that has cross‐species translational relevance to humans 24,29 . ALD‐52, 1P‐LSD, and 1B‐LSD have been shown to elicit the HTR and it appears that this is the result of LSD formation in vivo 18,24 .…”
Section: Introductionmentioning
confidence: 99%