Correlation between the number of allergen sensitizations and immunoglobulin E: monosensitization vs polysensitization

Kuperstock, Jacob E.; Brook, Christopher; Ryan, Matthew W.; Platt, Michael P.

doi:10.1002/alr.21890

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…As has been reported in other studies, most patients in our cohort were oligosensitized [34, 35]. Based on the discussion above on the role of HDM in allergy in Alberta, it is interesting that HDM was the most common mono-sensitizing allergen in our study, as has been reported before [36]. The retrospective nature of our study and the lack of clinical information for the tested subjects do not allow us to make conclusions on the significance of this observation.…”

Section: Discussionsupporting

confidence: 79%

Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada

Ahmed

Ospina²,

Sideri

et al. 2019

Allergy Asthma Clin Immunol

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Background Sensitization to common environmental aeroallergens plays a significant role in the pathogenesis and severity of respiratory allergic disorders, specifically asthma and allergic rhinitis. Understanding sensitization patterns helps clinicians tailor care more effectively. This study examines patterns of sensitization to aeroallergens in subjects suspected of having an allergic disease in Edmonton and catchment area. Methods Retrospective chart review of skin prick test (SPT) results to 11 environmental aeroallergens performed between January 1st and June 30th 2014 at a University-based clinic, where patients are referred for SPT by allergists, respirologists, otolaryngologists, internists and general practitioners. Potential differences in aeroallergen sensitization patterns were evaluated. Results A total of 623 patients (36.9% males; 63.1% females), aged 4–84 years (mean age 38.6 years) had SPT done, of which 438 (70.3%) had a positive test for at least one aeroallergen (atopy). There were no significant sex differences in the frequency of atopy (males: 71.3% versus females: 69.7%; p = 0.373). The frequency of sensitivity to particular allergens among atopic subjects was: cat (53.1%), house dust mites (50.3%), grass (39.2%), birch (23.7%), alternaria (23.7%), dog (17.3%), poplar (12.1%), cedar (9.6%), aspergillus (9.6%), hormodendrum (8%), and penicillium (6.2%). Of 438 atopic patients, 110 (25.1%) were mono sensitized, 199 (45.4%) oligosensitized (2–3 allergens), and 129 (29.5%) polysensitized (≥ 4 allergens). There were no significant differences between males and females in the odds of being oligo-sensitized (OR: 0.95; 95% CI 0.58, 1.57). Polysensitization was significantly more frequent in males 37.2% than in females 24.8%; (OR: 0.95; 95% CI 0.58, 1.57). Conclusion Cat is the most frequent perennial allergen and timothy grass pollen the most frequent seasonal allergen in Edmonton and catchment area. There was no significant difference in the frequency of atopy between males and females. However, males were more likely to be polysensitized compared to females.

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Section: Discussionsupporting

confidence: 79%

Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada

Ahmed

Ospina²,

Sideri

et al. 2019

Allergy Asthma Clin Immunol

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“…The absence of statistical significance in several of the comparisons might be due to the insufficiency of the sample number considered for the analysis or the technical instability of our protease assays. Serum total IgE reflects the degree of allergen sensitization [31,32]. Serum TARC is the most sensitive clinical biomarker of AD [33].…”

Section: Discussionmentioning

confidence: 99%

Multifaceted Analyses of Epidermal Serine Protease Activity in Patients with Atopic Dermatitis

Nomura

Suganuma

Takeichi

et al. 2020

IJMS

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The serine proteases kallikrein-related peptidase (KLK) 5 and KLK7 cleave cell adhesion molecules in the epidermis. Aberrant epidermal serine protease activity is thought to play an important role in the pathogenesis of atopic dermatitis (AD). We collected the stratum corneum (SC) from healthy individuals (n = 46) and AD patients (n = 63) by tape stripping and then measuring the trypsin- and chymotrypsin-like serine protease activity. We also analyzed the p.D386N and p.E420K of SPINK5 variants and loss-of-function mutations of FLG in the AD patients. The serine protease activity in the SC was increased not only in AD lesions but also in non-lesions of AD patients. We found, generally, that there was a positive correlation between the serine protease activity in the SC and the total serum immunoglobulin E (IgE) levels, serum thymus and activation-regulated chemokine (TARC) levels, and peripheral blood eosinophil counts. Moreover, the p.D386N or p.E420K in SPINK5 and FLG mutations were not significantly associated with the SC’s serine protease activity. Epidermal serine protease activity was increased even in non-lesions of AD patients. Such activity was found to correlate with a number of biomarkers of AD. Further investigations of serine proteases might provide new treatments and prophylaxis for AD.

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“…It is well established that total IgE is widely variable among patients with allergic diseases, particularly in patients with polysensitization. 33 Overall, the ideal management of allergic disease and anaphylaxis is strict avoidance of the trigger, if known. Hence, an attempt should always be made to identify the culprit, particularly in difficult cases or patients with a history of allergic episodes.…”

Section: Discussionmentioning

confidence: 99%

Anaphylaxis in Omani Patients: A Study from a Tertiary Care Center

Al‐Tamemi¹,

Lamki²,

Naseem³

et al. 2022

Oman Med J

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Objective: Anaphylaxis is an acute and potentially fatal allergic reaction. To the best of the author’s knowledge, no studies have yet been conducted to evaluate the spectrum of anaphylactic reactions among Omani patients. As such, this study aimed to describe the clinical features, causes, investigation, and management of anaphylaxis among patients presenting to a tertiary care center in Oman. Methods: This retrospective study took place between August 2005 and June 2020 at the allergy and immunology clinic of the Sultan Qaboos University Hospital, Muscat, Oman. All patients diagnosed with anaphylaxis during the study period were included. Data were collected from electronic medical records. Results: A total of 100 patients were diagnosed with anaphylaxis during the study period. Of these, 52% were male. The mean age was 15.9  16.2 years, with 70% being <18 years old. The eosinophil count ranged from 0–16.9 ×109 /L, with a mean of 0.8  2.2 ×109 /L and a median 2 of 0.30 (IQR: 0.15-0.65) ×109 /L. Total IgE levels ranged from 25–8,706 kIU/L, with a mean of 935.1  1369.5 kIU/L and a median of 500.4 (IQR: 186.0-972.5) kIU/L. Overall, the majority of patients had a family history of allergies (72%), other concomitant allergic condition (66%) and were all prescribed epinephrine (100%). The most common cause of anaphylaxis was food (65%), the second most frequent trigger was insect venom (32%). The majority of patients had one category cause (81%) however two or more causes were present in 19% of the patients. Clinical symptoms manifested most frequently as cutaneous (92%), and respiratory (85%). The majority of patients (87%) demonstrated involvement of more than one bodily system. Total IgE levels were significantly higher in patients with concomitant presence of other allergic conditions 1193.8 kIU/L compared to patients without another concomitant allergic disease mean 503.6 kIU/L (p=0.03). In addition, concomitant other allergic disease is significantly higher in patients <18 years of age 75.4% compared to patients >18 years of age 45.2% (p= 0.01). Conclusions: Due to its life-threatening nature, knowledge of the epidemiology and clinical features of anaphylaxis in different populations is necessary in order to deliver rapid treatment. This study found that the clinical features of anaphylactic patients in Oman were similar to those reported elsewhere. Further research is needed to determine the true incidence of anaphylaxis in Oman in order to minimize associated morbidity and mortality.

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Correlation between the number of allergen sensitizations and immunoglobulin E: monosensitization vs polysensitization

Abstract: IgE level can be used to predict monosensitization vs polysensitization. There is a moderate correlation between total IgE sensitization and the number of positive allergen sensitizations, as well as allergen class-weighted sensitizations.

Cited by 8 publications

References 27 publications

Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada

Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada

Multifaceted Analyses of Epidermal Serine Protease Activity in Patients with Atopic Dermatitis

Anaphylaxis in Omani Patients: A Study from a Tertiary Care Center

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