Correlation between the Nonperfusion Area on Ultra-Widefield Fluorescein Angiography and Nonflow Area on Optical Coherence Tomographic Angiography in Retinal Vein Occlusion

Abstract

Aims. To compare the relationship between the nonperfusion area (NPA) on ultra-widefield fluorescein angiography (UWFFA) and the nonflow area (NFA) on optical coherence tomographic angiography (OCTA) in retinal vein occlusion (RVO). Methods. Cross-sectional study. 46 eyes of 46 RVO patients who underwent UWFFA and OCTA. NPA and ischemic index (ISI) were quantified on UWWFA. NFA, vessel density (VD) of the superficial capillary plexus (SCP), the deep capillary plexus (DCP), and the size foveal avascular zone (FAZ) on 3 ∗ 3 mm OCTA were measured. The association of the NPA and ISI on UWWFA and the parameters on OCTA were analyzed. Spearman correlation was used for statistical testing. Results. The NPA and ISI on UWFFA were significantly correlated with the NFA on OCTA in RVO, and r values were 0.688 ( p < 0.01 ) and 0.680 ( p < 0.01 ), respectively. VD in the SCP of the temporal quadrant was negatively correlated with NPA and ISI, and r values were −0.346 ( p < 0.05 ) and −0.337 ( p < 0.05 ), respectively. VD in the DCP of the temporal quadrant was negatively correlated with the NPA, and the r value was −0.246 ( p < 0.05 ). No significant correlation was found between the NPA and ISI on UWFFA and VD of other quadrants in the SCP or DCP and the FAZ area on OCTA. Conclusion. NPA in the peripheral retina was correlated with NFA in macula. NFA detected by OCTA could be an indicator of the ischemic status in RVO.

Non-perfusion severity correlates with central macular thickness and microvascular impairment in branch retinal vein occlusions

“…Indeed, previous studies' results only considered the area that we identified as complete ischemia. [3][4][5]11 Our data reveal that ISI does not correlate with FAZ and BCVA in BRVO eyes. While these association are wellestablished in CRVO, their existence is debated in BRVO.…”

“…Additionally, there was no direct relationship between FAZ area and ISI, although a cut-off was found to identify patients with larger FAZ. 5,7 In terms of the effect of ISI on CMT, our data suggest that, in contrast to complete ischemia, only partial ischemia correlates with an increased CMT in BRVO eyes. However, in our study we could not find an association between the amount of pCNP and the response to anti-VEGF treatment in terms of CMT reduction.…”

“…2 In the latest years, several studies gathered data of BRVO patients to investigate the relation between PCN-P, quantified by using UWFFA, and macular microvascular changes, identified by OCTA. [3][4][5][6] More recently, non-perfusion areas have been subclassified in partial and complete ischemia, aiming to better understand the different clinical implication of the severity of peripheral ischemia. 7 In this investigation we aim to study PCN-P in BRVO eyes, by means of UWFFA, and to correlate its extent and severity with OCT and OCTA parameters, including microvascular changes, central macular thickness (CMT), and visual acuity.…”

A Case of Eales Disease Observed by Widefield Octa

“…There are some previous studies that have reported that the presence of the nonperfusion areas on UWFA is correlated with widefield OCTA. 7,8 However, our study is the first report to demonstrate that the peripheral nonperfusion area and retinal neovascularization could be identified with UWFA and widefield OCTA in a patient with Eales disease.…”

“…There are some previous studies that have reported that the presence of the nonperfusion areas on UWFA is correlated with widefield OCTA. 7,8 However, our study is the first report to demonstrate that the peripheral nonperfusion area and retinal neovascularization could be identified with UWFA and widefield OCTA in a patient with Eales disease. The differential diagnosis of Eales disease requires the exclusion of vascular occlusive diseases such as diabetic retinopathy, retinal vein occlusion, sarcoidosis, Behçet disease, Coats disease, familial exudative vitreoretinopathy, AIDS, tuberculosis, syphilis, and sickle cell disease.…”