Correlation between the Lactate Dehydrogenase Levels with Laboratory Variables in the Clinical Severity of Sickle Cell Anemia in Congolese Patients

Abstract

BackgroundSickle cell anemia is an inflammatory disease and is characterized by chronic hemolysis. We sought to evaluate the association of lactate dehydrogenase levels with specific clinical phenotypes and laboratory variables in patients with sickle cell anemia.MethodsThe present cross-sectional study was conducted in Sickle Cell Centre of Yolo in Kinshasa, the Democratic Republic of Congo. Two hundred and eleven patients with Sickle Cell Anemia in steady state were recruited. Seventy-four participants with normal Hb (Hb-AA) were selected as a control group.ResultsThe average rates of hemoglobin, hematocrit, and red blood cells tended to be significantly lower in subjects with Hb-SS (p<0.001). The average rates of white blood cells, platelets, reticulocytes and serum LDH were significantly higher in subjects with Hb-SS (p<0.001). The average rates of Hb, HbF, hematocrit and red blood cells of Hb-SS patients with asymptomatic clinical phenotype were significantly higher than those of the two other phenotypes. However, the average rates of white blood cells, platelets, reticulocytes, and LDH of Hb-SS patients with the severe clinical phenotype are higher than those of two other clinical phenotypes. Significant correlations were observed between Hb and white blood cell in severe clinical phenotype (r3 = -0.37 *) between Hb and red blood cells in the three phenotypes (r1 = 0.69 * r2 * = 0.69, r3 = 0.83 *), and finally between Hb and reticulocytes in the asymptomatic clinical phenotype and severe clinical phenotype (r1 = -0.50 * r3 = 0.45 *). A significant increase in LDH was observed in patients with leg ulcer, cholelithiasis and aseptic necrosis of the femoral head.ConclusionThe increase in serum LDH is accompanied by changes in hematological parameters. In our midst, serum LDH may be considered as an indicator of the severity of the disease.

Anemia and Micronutrient Status of Women of Childbearing Age and Children 6–59 Months in the Democratic Republic of the Congo

“…Anemia can have serious consequences for both women of reproductive age [ 2 , 3 , 4 ] and children [ 5 , 6 ]. Causes of anemia in the DRC include malaria [ 7 ], parasitic helminths and other infections [ 8 ], as well as sickle cell Hb [ 9 , 10 ]. Iron, folate, vitamin B12, vitamin A, zinc, and other micronutrient deficiencies can also contribute to anemia [ 11 ]; however, little is known about the micronutrient status of Congolese women of reproductive age and their young children [ 12 , 13 ].…”

Sickle Cell Disease: A Genetic Disorder of Beta-Globin

“…Other indicators of disease severity are bilirubin, PCV, erythropoiesis rate, leukocytes, LDH, fetal hemoglobin, creatinine, proteinuria, reticulocytes, HSV, phenotypes, days of hospitalization per year, severe vaso-occlusive crisis per year, number of transfusions per year, hip disease, leg ulcer, hepatobiliary complications, neurological events, renal disorders and body mass index [84,[119][120][121][122][123].…”

A Pilot Study Indicating Valuation of C‑Reactive Protein for Disease Outcome in Sickle Hemoglobin Patients of Central India

“…These studies have demonstrated a correlation between the serum LDH level and other markers of hemolysis such as bilirubin. 23 Also, red blood cell (RBC) count and haemoglobin (Hb) concentration alters in hemolysis. The identification of LDH may be considered as marker of hemolysis and might be an important tool for the early detection of the severity of the disease in HbS patients.…”