Correlation between the Intensity of Helicobacter pylori Colonization and Severity of Gastritis

Abstract

Background The most common cause of chronic gastritis is infection with Helicobacter pylori. Identifying the relationship between intensities of colonization and activity of gastritis helps the clinician in more effective treatment and posttreatment follow-ups. Methods In this cross-sectional study, endoscopic gastric biopsy samples of 544 patients who complained symptoms of dyspepsia for more than three months referring to the laboratory were studied. To determine the colonization rate of H. pylori and other pathological findings, Giemsa and H&E stains were, respectively, used. Results Among 544 subjects, 47 (8.64%) patients had no gastritis, 203 (37.32%) had mild gastritis, 278 (10.51%) suffered moderate gastritis, and 16 (2.94%) had severe gastritis. In this study, patients with mild H. pylori colonization rates had the highest level of mild activity (33.52%); in contrast, those with severe H. pylori colonization had the highest level of severe activity (43.75%). 93.96% of people with severe H. pylori colonization suffered from moderate and severe chronic gastritis. There is a significant statistical relationship between the intensity of H. pylori colonization and histopathological findings including intestinal metaplasia, atrophy, and lymphoid follicle formation. Conclusions According to the present study, with increasing intensity of H. pylori colonization, chronicity and activity of gastritis and its complications increase.

Association between Helicobacter pylori infection and kidney damage in patients with peptic ulcer

“…By referring to the research of Ghasemi Basir et al. [11], we used the Sydney system grading of chronic gastritis for grading of H. pylori density [12]. Scattered organisms covering less than one third of the surface are regarded as mild colonization ( H. pylori (+)); large clusters or a continuous layer over two-thirds of the surface is graded as severe ( H. pylori (+++)); intermediate numbers are mentioned as moderate colonization ( H. pylori (++)).…”

Correlation between the intensity of Helicobacter pylori colonization and severity of gastritis: Results of a prospective study

“…Our study showed that there is a statistically significant relationship between the severity of H. pylori infection and activity ( p value < .001), since patients with mild H. pylori colonization rates had the highest level of mild activity (59.5%) and those with severe H. pylori colonization had the highest level of severe activity (44.4%). Such a result was found in the study of Ghasemi Basir et al 9 conducted in Iran (2017) which showed that within people with mild H. pylori colonization, only 20.63% had severe activity while in intense colonization of H. pylori , 43.75% of the samples had severe activity. Also, in a recent study conducted in Morocco, 12 it was shown that the activity of antral and fundic gastritis was significantly associated with H. pylori density ( p < .001).…”

“…Several factors influence the pathogenicity of gastric H. pylori infection (smoking, alcoholism, medication, host genetic factors, and H. pylori genotypes) 6,7 . However, the correlation between the density of H. pylori colonization of the gastric mucosa and the severity of histological parameters of gastritis is debated 8,9 . To our knowledge, no study has determined this correlation in Tunisian population, an area with a high prevalence of H. pylori .…”

Stool Antigen Test is Effective and Sensitive for Detecting Helicobacter Pylori Infection in Bangladeshi Peptic Ulcer Patients

“…H. pylori concentration did not affect the activity and overall histological grading of chronic gastritis in their study. This dissimilarity may be due to genetic differences, nutritional habits, and environmental factors between the two study populations (Ghasemi et al, 2017). Among the 75 patients, 67 (89.33%) were positive, and 8 (10.67%) were found to be negative for the rapid urease test (RUT) in our study (Figure 3C).…”